Visible light optical coherence microscopy for quantitative imaging of human skin in vivo

Shau Poh Chong; Zhen Yu Gordon Ko; Nanguang Chen

doi:10.1117/12.2547149

19 February 2020 Visible light optical coherence microscopy for quantitative imaging of human skin in vivo

Shau Poh Chong, Zhen Yu Gordon Ko, Nanguang Chen

Proceedings Volume 11211, Photonics in Dermatology and Plastic Surgery 2020; 1121109 (2020) https://doi.org/10.1117/12.2547149
Event: SPIE BiOS, 2020, San Francisco, California, United States

Abstract

Recent development of visible light Optical Coherence Microscopy (i.e. Optical Coherence Tomography employing high numerical aperture Objective) has pushed the axial/transverse resolution limit to < 2 μm within tissues. Here, a fiber-based visible light Fourier domain (FD) Optical Coherence Microscopy system is presented, employing a 10x water immersion objective to achieve higher transverse resolution and reduced specular reflection when imaging human skin in vivo, using ~ 1-2 mW of incident power. Though with limited penetration depth, we demonstrated its application for in vivo imaging of human skin, and further measured the thicknesses of epidermis and dermo-epidermal junction. Furthermore, the total attenuation coefficient of the skin tissues was also estimated across epidermis and dermis.

Conference Presentation

Citation Download Citation

Shau Poh Chong, Zhen Yu Gordon Ko, and Nanguang Chen "Visible light optical coherence microscopy for quantitative imaging of human skin in vivo", Proc. SPIE 11211, Photonics in Dermatology and Plastic Surgery 2020, 1121109 (19 February 2020); https://doi.org/10.1117/12.2547149

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