Prof. Nanguang Chen Profile

Prof. Nanguang Chen

Associate Professor at National Univ of Singapore

SPIE Involvement:

Author

Area of Expertise:

Focal modulation microscopy , Time-resolved diffuse optical tomography , Optical coherence tomography

Websites:

Company Website

Publications (46)

SPIE Journal Paper | 29 November 2024 Open Access

Light-sheet dynamic scattering imaging of microscopic blood flow

Kai Long, Keertana Vinod Ram, Shuhao Shen, E. Du, Ziheng Ren, Zhiyuan Gong, Nanguang Chen

APN, Vol. 4, Issue 01, 016002, (November 2024) https://doi.org/10.1117/12.10.1117/1.APN.4.1.016002

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Proceedings Article | 9 October 2021 Presentation + Paper

Depth-dependent microscopic flow imaging with line scan laser speckle acquisition and analysis

E. Du, Shuhao Shen, Anqi Qiu, Nanguang Chen

Proceedings Volume 11900, 119000D (2021) https://doi.org/10.1117/12.2602189

KEYWORDS: Speckle, Blood circulation, Laser speckle contrast imaging, Confocal microscopy, Imaging systems, Laser speckle imaging, Laser systems engineering, Cameras, Temporal resolution, Spatial resolution

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Proceedings Article | 19 February 2020 Presentation + Paper

Visible light optical coherence microscopy for quantitative imaging of human skin in vivo

Shau Poh Chong, Zhen Yu Gordon Ko, Nanguang Chen

Proceedings Volume 11211, 1121109 (2020) https://doi.org/10.1117/12.2547149

KEYWORDS: Skin, Visible radiation, In vivo imaging, Optical coherence tomography, Signal attenuation, Imaging systems, Mirrors, Optical coherence microscopy, Image resolution, Objectives

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Proceedings Article | 4 March 2019 Presentation

Two-photon focal modulation microscopy for deep tissue imaging (Conference Presentation)

Rui Chen, Younghoon Shin, E. Du, Shuhao Shen, Peter T. So, Nanguang Chen

Proceedings Volume 10882, 108821D (2019) https://doi.org/10.1117/12.2509584

KEYWORDS: Modulation, Microscopy, Deep tissue imaging, Phase shift keying, Tissues, Phase only filters, Two photon excitation microscopy, Scattering, Spatial resolution, Modulators

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Proceedings Article | 4 March 2019 Presentation

Development of a ultrahigh speed line-scan OCT for measuring hemodynamics of chicken embryo's developing heart (Conference Presentation)

Shau Poh Chong, Zhen Yu Gordon Ko, Nanguang Chen

Proceedings Volume 10883, 108830C (2019) https://doi.org/10.1117/12.2510915

KEYWORDS: Hemodynamics, Optical coherence tomography, Heart, Line scan image sensors, Imaging systems, Blood circulation, Near infrared, Visualization, Fetus, Cardiovascular system

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SPIE Journal Paper | 8 May 2018 Open Access

Numerical modeling of two-photon focal modulation microscopy with a sinusoidal phase filter

Rui Chen, Shuhao Shen, Nanguang Chen

JBO, Vol. 23, Issue 05, 055002, (May 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.5.055002

KEYWORDS: Modulation, Phase shift keying, Image filtering, Point spread functions, Luminescence, Microscopy, Optical filters, Objectives, Numerical modeling, Electronic filtering

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Proceedings Article | 24 April 2018 Paper

Visualizing a beating zebrafish heart with improved line-scan microscopy

Nanguang Chen

Proceedings Volume 10711, 1071106 (2018) https://doi.org/10.1117/12.2321057

KEYWORDS: Heart, Line scan image sensors, Microscopy, Visualization, Signal to noise ratio, Modulation, Confocal microscopy, In vivo imaging, Interference (communication), Photons

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SPIE Journal Paper | 16 March 2018 Open Access

Effects of pupil filter patterns in line-scan focal modulation microscopy

Shuhao Shen, Shilpa Pant, Rui Chen, Nanguang Chen

JBO, Vol. 23, Issue 03, 036008, (March 2018) https://doi.org/10.1117/12.10.1117/1.JBO.23.3.036008

KEYWORDS: Modulation, Microscopy, Line scan image sensors, Microsoft Foundation Class Library, Luminescence, Image filtering, Optical filters, Tissues, Geometrical optics, Scattering

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Proceedings Article | 14 March 2018 Presentation

Two-photon focal modulation microscopy with sinusoidal continuous phase filters (Conference Presentation)

Rui Chen, Shuhao Shen, Nanguang Chen

Proceedings Volume 10499, 104990V (2018) https://doi.org/10.1117/12.2288857

KEYWORDS: Modulation, Microscopy, Phase shift keying, Tissues, Optical imaging, Multiphoton microscopy, Diffraction, Biological research, Scattering, Diagnostics

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Proceedings Article | 14 March 2018 Presentation

Optimization and characterization of a line-scan OCT for measuring hemodynamics of chicken embryo's developing heart with comparison to a point-scan OCT counterpart (Conference Presentation)

Shau Poh Chong, Zhen Yu Ko, Nanguang Chen

Proceedings Volume 10499, 104991G (2018) https://doi.org/10.1117/12.2288204

KEYWORDS: Optical coherence tomography, Hemodynamics, Line scan image sensors, Blood circulation, Near infrared, Imaging systems, Heart, Spectroscopy, Visualization, Light sources

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SPIE Journal Paper | 26 May 2017 Open Access

Line-scan focal modulation microscopy

Shilpa Pant, Caixia Li, Zhiyuan Gong, Nanguang Chen

JBO, Vol. 22, Issue 05, 050502, (May 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.5.050502

KEYWORDS: Modulation, Line scan image sensors, Imaging systems, Microscopy, Microscopes, Image acquisition, Image resolution, 3D acquisition, 3D image processing, Confocal microscopy

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SPIE Journal Paper | 6 April 2017 Open Access

Spread spectrum time-resolved diffuse optical measurement system for enhanced sensitivity in detecting human brain activity

Kalpesh Mehta, Ali Hasnain, Xiaowei Zhou, Jianwen Luo, Trevor Penney, Nanguang Chen

JBO, Vol. 22, Issue 04, 045005, (April 2017) https://doi.org/10.1117/12.10.1117/1.JBO.22.4.045005

KEYWORDS: Continuous wave operation, Photons, Brain, Absorption, Tissues, Optical testing, Scattering, Sensors, Hemodynamics, Data acquisition

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SPIE Journal Paper | 3 June 2016 Open Access

In vivo simultaneous multispectral fluorescence imaging with spectral multiplexed volume holographic imaging system

Yanlu Lv, Jiulou Zhang, Dong Zhang, Wenjuan Cai, Nanguang Chen, Jianwen Luo

JBO, Vol. 21, Issue 06, 060502, (June 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.6.060502

KEYWORDS: Multispectral imaging, Imaging systems, Multiplexing, Luminescence, Holograms, In vivo imaging, Holography, Volume holography, Diffraction, Sensors

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Proceedings Article | 27 April 2016 Presentation

Line-scan focal modulation microscopy: a comparison study (Conference Presentation)

Nanguang Chen, Shilpa Pant

Proceedings Volume 9713, 971308 (2016) https://doi.org/10.1117/12.2212710

KEYWORDS: Line scan image sensors, Modulation, Microscopy, Confocal microscopy, Phase modulation, Luminescence, Photons, Prototyping, Spatial resolution, 3D acquisition

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SPIE Journal Paper | 11 November 2014 Open Access

In vivo label-free quantification of liver microcirculation using dual-modality microscopy

Jie Yan, Yuzhan Kang, Shuoyu Xu, Lee-Ling Ong, Shuangmu Zhuo, Ralph Bunte, Nanguang Chen, H. Harry Asada, Peter T. So, Ian Wanless, Hanry Yu

JBO, Vol. 19, Issue 11, 116006, (November 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.11.116006

KEYWORDS: Liver, In vivo imaging, Microscopy, Speckle, Luminescence, Laser speckle contrast imaging, Blood, Tissues, Image filtering, Medical research

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Proceedings Article | 14 June 2013 Paper

Developing a robust time domain diffuse optical tomography system

Ali Hasnain, Kalpesh Mehta, Zhang Qiang, Nanguang Chen

Proceedings Volume 8799, 87990B (2013) https://doi.org/10.1117/12.2033153

KEYWORDS: Modulation, Avalanche photodetectors, Vertical cavity surface emitting lasers, Diffuse optical tomography, Photons, Signal to noise ratio, Signal detection, Imaging systems, Semiconductor lasers, Modulators

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Proceedings Article | 29 November 2011 Paper

An optimized engineering design of imaging probe for time-resolved diffuse optical tomography system

Ling Chen, Ali Hasnain, Nanguang Chen

Proceedings Volume 8311, 83110L (2011) https://doi.org/10.1117/12.904245

KEYWORDS: Imaging systems, Sensors, Absorption, Spatial resolution, Diffuse optical tomography, Diffuse optical imaging, Tissue optics, Tissues, Signal detection, Image restoration

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Proceedings Article | 29 November 2011 Paper

Line-scan focal modulation microscopy for rapid imaging of thick biological specimens

Shau Poh Chong, Shilpa Pant, Nanguang Chen

Proceedings Volume 8311, 83111C (2011) https://doi.org/10.1117/12.904115

KEYWORDS: Line scan image sensors, Modulation, Microscopy, Luminescence, Microscopes, Tissues, Objectives, Image processing, Image quality, Spatial resolution

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SPIE Journal Paper | 1 March 2011 Open Access

Optimization of source and detector configurations based on Cramer-Rao lower bound analysis

Ling Chen, Nanguang Chen

JBO, Vol. 16, Issue 03, 035001, (March 2011) https://doi.org/10.1117/12.10.1117/1.3549738

KEYWORDS: Sensors, Imaging systems, Diffuse optical imaging, Image quality, Absorption, Computer simulations, Target detection, Inverse problems, Tissue optics, Optical properties

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Proceedings Article | 22 February 2011 Paper

Pseudo-random single photon counting system: a high speed implementation and its applications

Qiang Zhang, Nanguang Chen

Proceedings Volume 7891, 78910G (2011) https://doi.org/10.1117/12.874390

KEYWORDS: Photons, Blood, Glucose, Single photon, Picosecond phenomena, Spectroscopy, Transparency, Transmitters, Modulation, Sensors

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Proceedings Article | 11 February 2011 Paper

High-speed focal modulation microscopy using acousto-optical modulators for visualization of thick biological specimens

Shau Poh Chong, Guangjun Gao, Colin J. Sheppard, Nanguang Chen

Proceedings Volume 7904, 79040C (2011) https://doi.org/10.1117/12.873996

KEYWORDS: Luminescence, Modulation, Microscopy, Confocal microscopy, Image quality, Bragg cells, Curium, Visualization, Modulators, Tissues

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Proceedings Article | 25 February 2010 Paper

Real-time focal modulation microscopy

N. Chen, C. Wong, S. Chong, C. J. Sheppard

Proceedings Volume 7570, 75700Q (2010) https://doi.org/10.1117/12.841511

KEYWORDS: Modulation, Modulators, Microscopy, Phase shift keying, Confocal microscopy, Electronics, Microscopes, Luminescence, Signal detection, Imaging systems

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Proceedings Article | 24 February 2010 Paper

High count rate pseudo-random single photon counting system for time-resolved diffuse optical imaging

Qiang Zhang, Nanguang Chen

Proceedings Volume 7556, 755604 (2010) https://doi.org/10.1117/12.841924

KEYWORDS: Single photon, Photons, Signal detection, Modulation, Diffuse optical imaging, Glucose, Imaging systems, Optical testing, Time metrology, Picosecond phenomena

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SPIE Journal Paper | 1 January 2010 Open Access

Multistage inversion algorithm for biological tissue imaging

Krishna Agarwal, Ling Chen, Nanguang Chen, Xudong Chen

JBO, Vol. 15, Issue 01, 016007, (January 2010) https://doi.org/10.1117/12.10.1117/1.3290809

KEYWORDS: Tissues, Sensors, Tissue optics, Reconstruction algorithms, Absorption, Diffusion, Statistical analysis, Inverse problems, Computer engineering, Signal processing

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SPIE Journal Paper | 1 November 2009 Open Access

Quantitative characterization of optical and physiological parameters in normal breasts using time-resolved spectroscopy: in vivo results of 19 Singapore women

Weirong Mo, Tyrphena Chan, Ling Chen, Nanguang Chen

JBO, Vol. 14, Issue 06, 064004, (November 2009) https://doi.org/10.1117/12.10.1117/1.3257251

KEYWORDS: Breast, Tissue optics, Tissues, Optical properties, Optical fibers, In vivo imaging, Biomedical optics, Time resolved spectroscopy, Molybdenum, Absorption

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Proceedings Article | 24 February 2009 Paper

Pseudo-random single photon counting: the principle, simulation, and experimental results

Qiang Zhang, Nan Guang Chen

Proceedings Volume 7170, 71700L (2009) https://doi.org/10.1117/12.807793

KEYWORDS: Photons, Single photon, Signal detection, Data acquisition, Optical testing, Modulation, Prototyping, Picosecond phenomena, Transmitters, Oscilloscopes

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Proceedings Article | 23 February 2009 Paper

Source stabilization for high quality time-domain diffuse optical tomography

Weirong Mo, Nanguang Chen

Proceedings Volume 7170, 71700N (2009) https://doi.org/10.1117/12.808188

KEYWORDS: Modulation, Modulators, Diffuse optical tomography, Feedback control, Near infrared, Photorefraction, Data acquisition, Interferometry, Electrooptic modulators, Temperature metrology

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Proceedings Article | 28 February 2008 Paper

Novel 3D micromirror for miniature optical bio-probe SiOB assembly

Janak Singh, Yingshun Xu, C. Premachandran, Teo Hui Siang Jason, Nanguang Chen

Proceedings Volume 6886, 688608 (2008) https://doi.org/10.1117/12.762544

KEYWORDS: Micromirrors, Mirrors, Silicon, Tissue optics, Optical coherence tomography, Etching, Actuators, Light scattering, Microelectromechanical systems, Deep reactive ion etching

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Proceedings Article | 18 February 2008 Paper

Dynamic focusing with radial gratings for in vivo high resolution imaging

Linbo Liu, Nanguang Chen

Proceedings Volume 6847, 684718 (2008) https://doi.org/10.1117/12.760675

KEYWORDS: Image resolution, Objectives, In vivo imaging, Signal to noise ratio, Confocal microscopy, Point spread functions, Spatial resolution, Optical coherence microscopy, Mirrors, Modulation

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Proceedings Article | 12 February 2008 Paper

High performance time-resolved diffuse optical tomography system

Weirong Mo, Nanguang Chen

Proceedings Volume 6849, 684904 (2008) https://doi.org/10.1117/12.761703

KEYWORDS: Picosecond phenomena, Avalanche photodetectors, Tissues, Tumors, Data acquisition, Modulators, Diffuse optical tomography, Modulation, Temporal resolution, Sensors

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Proceedings Article | 11 July 2007 Paper

MEMS-based non-rotatory circumferential scanning optical probe for endoscopic optical coherence tomography

Yingshun Xu, Janak Singh, Teo Hui Siang, Kotlanka Ramakrishna, C. S. Premchandran, Chen Wei Sheng, Chuah Tong Kuan, Nanguang Chen, Malini Olivo, Colin Sheppard

Proceedings Volume 6627, 662715 (2007) https://doi.org/10.1117/12.726736

KEYWORDS: Micromirrors, Actuators, Mirrors, Silicon, Optical coherence tomography, Endoscopy, Microelectromechanical systems, GRIN lenses, 3D scanning, Aluminum

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Proceedings Article | 13 February 2007 Paper

Optical coherent tomography (OCT) bio-imaging using 3D scanning micromirror

J. Singh, Chan Hoe, Teo Jason, C. Nanguang, C. Premachandran, Collin Sheppard, M. Olivo

Proceedings Volume 6432, 64320C (2007) https://doi.org/10.1117/12.702279

KEYWORDS: Micromirrors, Optical coherence tomography, 3D scanning, Mirrors, Tissues, Tissue optics, GRIN lenses, Integrated optics, Actuators, 3D image processing

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Proceedings Article | 28 April 2005 Paper

Tumor angiogenesis and tumor hypoxia as diagnostic indices for differentiation of benign versus malignant breast masses

Quing Zhu, Scott Kurtzman, Edward Cronin, Mark Kane, Minming Huang, Chen Xu, NanGuang Chen, Daqing Piao, Poornima Hedge, Susan Tannenbaum, Bipin Jagjivan, Kristen Zarfos

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.592596

KEYWORDS: Tumors, Hypoxia, Breast, Diagnostics, Ultrasonography, Biopsy, Oxygen, Absorption, Tissue optics, Skin

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SPIE Journal Paper | 1 March 2005 Open Access

Locating inhomogeneities in tissue by using the most probable diffuse path of light

Jing Bai, Tianxin Gao, Kui Ying, NanGuang Chen

JBO, Vol. 10, Issue 02, 024024, (March 2005) https://doi.org/10.1117/12.10.1117/1.1896968

KEYWORDS: Sensors, Near infrared, Tissue optics, Tissues, Absorption, Breast cancer, Breast, Quasiparticles, Diffusion, Photons

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Proceedings Article | 1 July 2004 Paper

Lanthanide-enhanced luminescence (LEL) with one and two photon excitation of Quantum Dyes lanthanide(III)-macrocycles

Robert Leif, Margie Becker, Alfred Bromm, Nanguang Chen, Ann Cowan, Lidia Vallarino, Sean Yang, Robert Zucker

Proceedings Volume 5322, (2004) https://doi.org/10.1117/12.530284

KEYWORDS: Luminescence, Lanthanides, Bioalcohols, Europium, Dysprosium, Terbium, Cell biology, Ultraviolet radiation, Confocal microscopy, Two photon excitation microscopy

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SPIE Journal Paper | 1 May 2004 Open Access

Portable near-infrared diffusive light imager for breast cancer detection

Nanguang Chen, Minming Huang, Hongjun Xia, Daqing Piao, Edward Cronin, Quing Zhu

JBO, Vol. 9, Issue 03, (May 2004) https://doi.org/10.1117/12.10.1117/1.1695410

KEYWORDS: Imaging systems, Data acquisition, Ultrasonography, Breast cancer, Optical switching, Semiconductor lasers, Avalanche photodetectors, Absorption, Avalanche photodiodes, Sensors

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SPIE Journal Paper | 1 May 2004 Open Access

Emission and absorption properties of indocyanine green in Intralipid solution

Baohong Yuan, Nanguang Chen, Quing Zhu

JBO, Vol. 9, Issue 03, (May 2004) https://doi.org/10.1117/12.10.1117/1.1695411

KEYWORDS: Absorption, Photons, Atrial fibrillation, Molecules, Signal detection, Diffusion, Sensors, Scattering, Indocyanine green, Molecular aggregates

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Proceedings Article | 29 July 2003 Paper

Breast lesion diagnosis using combined near-infrared diffusive light and ultrasound: initial clinical results

Quing Zhu, Scott Kurtzman, Minming Huang, Nan Guang Chen, Kristen Zarfos, Bipin Jagjivan, Mark Kane

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478220

KEYWORDS: Ultrasonography, Absorption, Breast, Tissue optics, Cancer, Solids, Near infrared, Optical tomography, Tissues, Biopsy

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Proceedings Article | 29 July 2003 Paper

Three-dimensional simultaneous absorption and scattering coefficient reconstruction for reflection geometry

Minming Huang, Nan Guang Chen, Baohong Yuan, Quing Zhu

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478181

KEYWORDS: Absorption, Scattering, Calibration, Diffusion, Ultrasonography, Near infrared, 3D acquisition, Light scattering, 3D image processing, Image restoration

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Proceedings Article | 29 July 2003 Paper

Portable multichannel multiwavelength near-infrared diffusive light imager

Nan Guang Chen, Hongjun Xia, Daqing Piao, Quing Zhu

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478165

KEYWORDS: Avalanche photodetectors, Optical switching, Imaging systems, Sensors, Signal detection, Control systems, Semiconductor lasers, Calibration, Optical tomography, Optical fibers

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Proceedings Article | 29 July 2003 Paper

Spread spectrum time-resolved photon migration imaging system: the principle and simulation results

Nan Guang Chen, Quing Zhu

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478166

KEYWORDS: Imaging systems, Signal to noise ratio, Single photon, Data acquisition, Photonics systems, Modulation, Breast cancer, Scattering, Absorption, Transmitters

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Proceedings Article | 10 July 2003 Paper

Fluorescence decay profile measured with spread spectrum excitations

Nan Guang Chen, Quing Zhu

Proceedings Volume 4963, (2003) https://doi.org/10.1117/12.478008

KEYWORDS: Luminescence, Modulation, Light sources, Fluorometers, Data acquisition, Time resolved spectroscopy, Light emitting diodes, Imaging spectroscopy, Ultraviolet radiation, Signal processing

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Proceedings Article | 9 July 2003 Paper

Fast scanning confocal microscopy with a rotary mirror array

Nanguang Chen, Quing Zhu

Proceedings Volume 4964, (2003) https://doi.org/10.1117/12.478339

KEYWORDS: Mirrors, Confocal microscopy, Objectives, Telescopes, Microscopes, Signal processing, Signal detection, Light sources, Beam splitters, Spatial resolution

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Proceedings Article | 29 June 2001 Paper

Optical tomography with early arriving photons: sensitivity and resolution analysis

Nanguang Chen, Quing Zhu

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434507

KEYWORDS: Scattering, Photons, Tissues, Monte Carlo methods, Spatial resolution, Light scattering, Optical tomography, Sensors, Absorption, Transmittance

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Proceedings Article | 29 June 2001 Paper

Ultrasound-assisted NIR imaging for breast cancer detection

Nanguang Chen, Puyun Guo, Shikui Yan, Daqing Piao, Quing Zhu

Proceedings Volume 4250, (2001) https://doi.org/10.1117/12.434530

KEYWORDS: Ultrasonography, Near infrared, Absorption, Transducers, Optical fibers, Optical properties, Sensors, Reconstruction algorithms, Imaging systems, Breast cancer

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Proceedings Article | 15 June 2001 Paper

Near-infrared probe design with ultrasound guidance

Quing Zhu, Nanguang Chen, Daqing Piao, Puyun Guo

Proceedings Volume 4256, (2001) https://doi.org/10.1117/12.429313

KEYWORDS: Ultrasonography, Absorption, Sensors, Transducers, Tissue optics, 3D image processing, Optical properties, 3D acquisition, Reflection, Protactinium

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Showing 5 of 46 publications

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