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10 March 2020 Tumor margin assessment using frozen sections can be improved by paired-agent imaging (Conference Presentation)
Kimberley S. Samkoe, Cheng Wang, Eunice Chen, Laura Tafe, Kenneth Tichauer
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Proceedings Volume 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI; 112220N (2020) https://doi.org/10.1117/12.2547011
Event: SPIE BiOS, 2020, San Francisco, California, United States
Abstract
During resection of head and neck cancers, surgeons collect multiple small tissue samples from the excision wound bed for “frozen section” analysis by a clinical pathologist to determine clear margins. However, this process is disruptive to work flow, time-consuming, and expensive. We have validated Paired-Agent Imaging (PAI) in in vivo xenograft models using epidermal growth factor receptor and demonstrated that PAI exhibits higher diagnostic accuracy targeted agent alone – tested in both fresh tissue (~3-mm) and frozen sections (10-m). Here PAI will be extended to screening of tissue biopsies to quantify tumor burden in comparison to standard frozen section pathology.
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Kimberley S. Samkoe, Cheng Wang, Eunice Chen, Laura Tafe, and Kenneth Tichauer "Tumor margin assessment using frozen sections can be improved by paired-agent imaging (Conference Presentation)", Proc. SPIE 11222, Molecular-Guided Surgery: Molecules, Devices, and Applications VI, 112220N (10 March 2020); https://doi.org/10.1117/12.2547011
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KEYWORDS
Tumors
Tissues
Diagnostics
Head
Neck
Pathology
Receptors
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