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5 March 2021 Phase sensitive coherence gated quantitative imaging for investigating intracellular and cellular dynamics
Mantas Žurauskas, Rishyashring R. Lyer, Stephen A. Boppart
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Proceedings Volume 11653, Quantitative Phase Imaging VII; 116530N (2021) https://doi.org/10.1117/12.2578333
Event: SPIE BiOS, 2021, Online Only
Abstract
We present a novel optical coherence microscopy (OCM) implementation which permits accurate measurements of intensity and phase of light returned from the sample. We demonstrate the capacity to acquire stable phase recordings with a phase sensitivity of 0.1 nm rms at 500 Hz frame rates with a field-of-view of 250x250 µm and 1 µm lateral resolution. Instantaneous, coherence gated, quantitative phase imaging at high frame rates enables observations of the dynamics in cells and tissues, providing instant feedback on metabolic activity and tissue states. We demonstrate applications of the technology for ultrasensitive measurement of intracellular activity and cellular dynamics in cell cultures.
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Mantas Žurauskas, Rishyashring R. Lyer, and Stephen A. Boppart "Phase sensitive coherence gated quantitative imaging for investigating intracellular and cellular dynamics", Proc. SPIE 11653, Quantitative Phase Imaging VII, 116530N (5 March 2021); https://doi.org/10.1117/12.2578333
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KEYWORDS
Coherence imaging
Coherence (optics)
Gated imaging
Phase shifts
Tissues
Interferometry
Light emitting diodes
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