Two-distance partial pathlength method for accurate measurement of muscle oxidative metabolism using fNIRS

Ömer Şayli; Ata Akın

doi:10.1117/12.644603

1 March 2006 Two-distance partial pathlength method for accurate measurement of muscle oxidative metabolism using fNIRS

Ömer Şayli, Ata Akın

Proceedings Volume 6084, Optical Interactions with Tissue and Cells XVII; 60840O (2006) https://doi.org/10.1117/12.644603
Event: SPIE BiOS, 2006, San Jose, California, United States

Abstract

Near infrared spectroscopy (NIRS) is now a commonly accepted method for the measurement of oxidative metabolism of brain and muscle tissues. Nevertheless, this technology suffers from the error caused by the homogeneous single layer assumption in the calculations of concentration changes of light absorber chromophores using either diffusion theory or modified Beer-Lambert law. Underestimation of muscle oxidative metabolism for muscles having thicker fat layer above is a particular case. Due to this uncertainty, statistical analysis can be problematic in reviewing the results across subjects having different fat thicknesses for muscle studies. In this study, partial pathlength method with two detectors based on modified Beer-Lambert law extended for heterogeneous medium with homogeneous layered regions is investigated. Using Monte Carlo simulations, comparison between this technique and single homogeneous layer assumption is done. Optical coefficients of fat and muscle layers are chosen typical for muscle tissue measurements. In the simulations, change of absorption coefficient in muscle layer was made much bigger than in fat layer. It has been found that for 2-detector partial pathlength based method, fat and muscle layer absorption coefficient change estimates are better than the homogeneous medium based modified Beer-Lambert law estimates in all simulated cases.

Citation Download Citation

Ömer Şayli and Ata Akın "Two-distance partial pathlength method for accurate measurement of muscle oxidative metabolism using fNIRS", Proc. SPIE 6084, Optical Interactions with Tissue and Cells XVII, 60840O (1 March 2006); https://doi.org/10.1117/12.644603

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available