Interaction of a dual-wavelength laser system with cutaneous blood vessels

Boris Majaron; Matija Milanič; J. Stuart Nelson

doi:10.1117/12.728457

13 July 2007 Interaction of a dual-wavelength laser system with cutaneous blood vessels

Boris Majaron, Matija Milanič, J. Stuart Nelson

Proceedings Volume 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III; 66320C (2007) https://doi.org/10.1117/12.728457
Event: European Conferences on Biomedical Optics, 2007, Munich, Germany

Abstract

Our working hypothesis is that a dual-wavelength Nd:YAG laser, emitting simultaneously at 1064 and 532 nm, may induce stronger heating of PWS blood vessels relative to the epidermis than the customary KTP laser, due to conversion of hemoglobin to met-hemoglobin in the target blood vessels and the associated increase in NIR absorption. We apply pulsed photothermal radiometry to determine temperature depth profiles induced in PWS lesions by a dual-wavelength laser at sub-therapeutic radiant exposures. The results indicate no effect at 1 ms pulse duration and low radiant exposures (1-2 J/cm²). Increased radiant exposure (3-4 J/cm²) and extended pulse duration (20-25 ms) result in increased energy deposition. In addition, two PWS lesions and one healthy skin site were irradiated at incrementally increasing radiant exposures, up to 9 J/cm². Analysis of the laser-induced temperature profiles clearly revealed irreversible changes of tissue properties. Formation of met-hemoglobin and consequent increase of IR absorption was however not reliably detected.

Citation Download Citation

Boris Majaron, Matija Milanič, and J. Stuart Nelson "Interaction of a dual-wavelength laser system with cutaneous blood vessels", Proc. SPIE 6632, Therapeutic Laser Applications and Laser-Tissue Interactions III, 66320C (13 July 2007); https://doi.org/10.1117/12.728457

ACCESS THE FULL ARTICLE

INSTITUTIONAL
Select your institution to access the SPIE Digital Library.

SELECT YOUR INSTITUTION

PERSONAL
Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.

PERSONAL SIGN IN

No SPIE Account? Create one

PURCHASE THIS CONTENT

SUBSCRIBE TO DIGITAL LIBRARY

50 downloads per 1-year subscription

Members: $195

Non-members: $335 ADD TO CART

25 downloads per 1 - year subscription

Members: $145

Non-members: $250 ADD TO CART

PURCHASE SINGLE ARTICLE

Includes PDF, HTML & Video, when available