Imaging of mouse embryonic eye development using optical coherence tomography

Saba H. Syed; Alyssa Kasiraj; Irina V. Larina; Mary E. Dickinson; Kirill V. Larin

doi:10.1117/12.842332

2 March 2010 Imaging of mouse embryonic eye development using optical coherence tomography

Saba H. Syed, Alyssa Kasiraj, Irina V. Larina, Mary E. Dickinson, Kirill V. Larin

Proceedings Volume 7550, Ophthalmic Technologies XX; 75501A (2010) https://doi.org/10.1117/12.842332
Event: SPIE BiOS, 2010, San Francisco, California, United States

Abstract

Congenital abnormalities are often caused by genetic disorders which alter the normal development of the eye. Embryonic eye imaging in mouse model is important for understanding of normal and abnormal eye development and can contribute to prevention and treatment of eye defects in humans. In this study, we used Swept Source Optical Coherence Tomography (SS-OCT) to image eye structure in mouse embryos at 12.5 to 17.5 days post coitus (dpc). The imaging depth of the OCT allowed us to visualize the whole eye globe at these stages. Different ocular tissues including lens, cornea, eyelids, and hyaloid vasculature were visualized. These results suggest that OCT imaging is a useful tool to study embryonic eye development in the mouse model.

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Saba H. Syed, Alyssa Kasiraj, Irina V. Larina, Mary E. Dickinson, and Kirill V. Larin "Imaging of mouse embryonic eye development using optical coherence tomography", Proc. SPIE 7550, Ophthalmic Technologies XX, 75501A (2 March 2010); https://doi.org/10.1117/12.842332

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KEYWORDS

Eye

Optical coherence tomography

Visualization

Cornea

Mouse models

Tissues

Genetics

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