Prof. Irina V. Larina Profile

Prof. Irina V. Larina

Professor at Baylor College of Medicine

SPIE Involvement:

Conference Program Committee | Author

Publications (72)

Proceedings Article | 13 March 2024 Presentation

Comparison of continuous and pulsed optogenetic stimulation for embryonic cardiodynamic studies

Guzel Musina, Deirdre Scully, Andrew Lopez, Irina Larina

Proceedings Volume 12819, 128190L (2024) https://doi.org/10.1117/12.3005599

KEYWORDS: Optogenetics, Animal model studies, Proteins, Heart, Biomechanics, Organisms, Genetics, Diagnostics, Animals

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Proceedings Article | 13 March 2024 Presentation

Dynamic OCT for in vivo cilia metachronal wave analysis in the mouse fallopian tube

Tian Xia, Shang Wang, Irina Larina

Proceedings Volume PC12841, PC1284102 (2024) https://doi.org/10.1117/12.3006504

KEYWORDS: Optical coherence tomography, In vivo imaging, Fallopian tube, Visualization, Reproductive system, Wave propagation, Tissues, Pathology, Mouse models, Genetics

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Proceedings Article | 13 March 2024 Presentation

Quantitative OCT angiography for blood flow analysis in mouse embryonic cardiovascular system

Michaela McCown, Irina Larina

Proceedings Volume 12819, 128190O (2024) https://doi.org/10.1117/12.3005708

KEYWORDS: Blood circulation, Optical coherence tomography, Heart, Angiography, Cardiovascular system, Statistical analysis, Biomechanics, Visualization, Tissues, Statistical methods

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Proceedings Article | 13 March 2024 Presentation + Paper

Functional optical coherence tomography (OCT) for mapping of cilia beat frequency in the human fallopian tube ex vivo

Dilara Long, Photini Rice, Deirdre Scully, Tian Xia, Ryan Walton, Andrea Aguirre, John Heusinkveld, Irina Larina, Jennifer Barton

Proceedings Volume 12831, 1283108 (2024) https://doi.org/10.1117/12.3002970

KEYWORDS: Optical coherence tomography, Tissues, Speckle, Microscopy, Video, Fallopian tube, Biological samples, Histograms, Visualization

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Proceedings Article | 12 March 2024 Presentation + Paper

Quantitative OCT angiography for dynamic volumetric analysis in embryonic cardiovascular system

Michaela McCown, Irina Larina

Proceedings Volume 12841, 1284103 (2024) https://doi.org/10.1117/12.3005714

KEYWORDS: Heart, Optical coherence tomography, Blood circulation, Particles, Angiography, Cardiovascular system, Animal model studies, Tissues, Speckle, Signal intensity, Hemodynamics

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Proceedings Article | 17 March 2023 Presentation

Longitudinal high-resolution 4D imaging of the mouse embryonic heart development with optical coherence tomography

Andre Faubert, Irina Larina, Shang Wang

Proceedings Volume PC12355, PC123550C (2023) https://doi.org/10.1117/12.2649559

KEYWORDS: Heart, Optical coherence tomography, Mouse models, Confocal microscopy, Wave propagation, Visualization, Microscopy, Light emitting diodes, Hemodynamics, Coherence (optics)

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Proceedings Article | 7 March 2023 Presentation + Paper

Quantitative OCT angiography toward 4D blood flow analysis in embryonic cardiovascular system

Michaela McCown, Irina Larina

Proceedings Volume 12378, 1237809 (2023) https://doi.org/10.1117/12.2656704

KEYWORDS: Optical coherence tomography, Heart, Blood circulation, Angiography, Particles, Blood, Biomechanics, Biological imaging, Cardiovascular system, Visualization

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Proceedings Article | 7 March 2023 Presentation + Paper

In vivo dynamic quantitative imaging of cilia metachronal wave in mouse fallopian tube with optical coherence tomography

Tian Xia, Shang Wang, Irina Larina

Proceedings Volume 12378, 1237802 (2023) https://doi.org/10.1117/12.2656886

KEYWORDS: Optical coherence tomography, Fallopian tube, In vivo imaging, Imaging systems, Wave propagation, Visualization, Tissues, Statistical analysis, Biological imaging, Windows

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Proceedings Article | 7 March 2023 Presentation

A method for efficient 4D reconstruction of cardio-and hemodynamics in the embryonic mouse using OCT

Andre Faubert, Irina Larina, Shang Wang

Proceedings Volume PC12378, PC123780A (2023) https://doi.org/10.1117/12.2649349

KEYWORDS: Optical coherence tomography, Heart, Hemodynamics, 3D acquisition, Visualization, Luminescence, Data acquisition, Confocal microscopy, Automatic alignment, 3D image processing

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Proceedings Article | 30 May 2022 Presentation

In vivo biophotonic analysis of preimplantation embryonic development

Irina Larina

Proceedings Volume PC12144, PC121440Y (2022) https://doi.org/10.1117/12.2626872

KEYWORDS: In vivo imaging, Biomedical optics, Biological research, Optical coherence tomography, Fallopian tube, Visualization, Mouse models, In vitro testing

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Proceedings Article | 7 March 2022 Paper

Single-shot dynamic line-field optical coherence elastography at 11.5 MHz

Manmohan Singh, Alexander Schill, Achuth Nair, Salavat Aglyamov, Irina Larin, Kirill Larin

Proceedings Volume 11948, 119480B (2022) https://doi.org/10.1117/12.2609979

KEYWORDS: Ultrafast phenomena, Optical coherence tomography, Cornea, Tissues, Elastography, Imaging systems, Wave propagation, Coherence (optics), Singular optics, Signal to noise ratio

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Proceedings Article | 7 March 2022 Presentation

Optogenetic investigation of mouse embryonic cardiogenesis with continuous-wave light stimulation

Deirdre Scully, Andrew Lopez, Irina Larina

Proceedings Volume PC11936, PC119360C (2022) https://doi.org/10.1117/12.2609124

KEYWORDS: Optogenetics, Continuous wave operation, Heart, Sodium, Proteins, Neuroscience, Ions, Hemodynamics, Genetics, Biomedical optics

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Proceedings Article | 2 March 2022 Paper

Tracking spermatozoa movement toward the egg with functional optical coherence tomography

Tian Xia, Kohei Umezu, Shang Wang, Irina Larina

Proceedings Volume 11959, 1195902 (2022) https://doi.org/10.1117/12.2608265

KEYWORDS: Optical coherence tomography, In vivo imaging, Visualization, Optical tracking, Speckle, Signal detection, In vitro testing, Imaging systems, Control systems, Microscopy

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Proceedings Article | 2 March 2022 Presentation

Dynamic volumetric imaging of ovulated egg transport to the fallopian tube with optical coherence tomography

Kohei Umezu, Shang Wang, Irina Larina

Proceedings Volume PC11959, PC119590H (2022) https://doi.org/10.1117/12.2610328

KEYWORDS: Optical coherence tomography, Fallopian tube, Ovary, In vivo imaging, Tissues, Pathology, Mouse models, Genetics

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Proceedings Article | 2 March 2022 Presentation

Quantitative OCT analysis of sperm hyperactivation state in mouse fallopian tube

Zheng-Chen Yao, Shang Wang, Irina Larina

Proceedings Volume PC11959, PC119590I (2022) https://doi.org/10.1117/12.2610364

KEYWORDS: Optical coherence tomography, In vivo imaging, Fallopian tube, Visualization, Velocity measurements, Tissues, Optical tracking, In vitro testing

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Proceedings Article | 2 March 2022 Presentation

Live biophotonic analysis of embryonic development

Irina Larina

Proceedings Volume PC11959, PC119590E (2022) https://doi.org/10.1117/12.2631528

SPIE Journal Paper | 5 August 2020 Open Access

Live mechanistic assessment of localized cardiac pumping in mammalian tubular embryonic heart

Shang Wang, Irina Larina

JBO, Vol. 25, Issue 08, 086001, (August 2020) https://doi.org/10.1117/12.10.1117/1.JBO.25.8.086001

KEYWORDS: Heart, Blood circulation, Resistance, Optical coherence tomography, Video, Blood, Hemodynamics, Doppler effect, Imaging systems

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Significance: Understanding how the valveless embryonic heart pumps blood is essential to elucidate biomechanical cues regulating cardiogenesis, which is important for the advancement of congenital heart defects research. However, methods capable of embryonic cardiac pumping analysis remain limited, and assessing this highly dynamic process in mammalian embryos is challenging. New approaches are critically needed to address this hurdle. Aim: We report an imaging-based approach for functional assessment of localized pumping dynamics in the early tubular embryonic mouse heart. Approach: Four-dimensional optical coherence tomography was used to obtain structural and Doppler hemodynamic imaging of the beating heart in live mouse embryos at embryonic day 9.25. The pumping assessment was performed based on the volumetric blood flow rate, flow resistance within the heart tube, and pressure gradient induced by heart wall movements. The relation between the blood flow, the pressure gradient, and the resistance to flow were evaluated through temporal analyses and Granger causality test. Results: In the ventricles, our method revealed connections between the temporal profiles of pressure gradient and volumetric blood flow rate. Statistically significant causal relation from the pressure gradient to the blood flow was demonstrated. Our analysis also suggests that cardiac pumping in the early ventricles is a combination of suction and pushing. In contrast, in the outflow tract, where the conduction wave is slower than the blood flow, we did not find significant causal relation from pressure to flow, suggesting that, different from ventricular regions, the local active contraction of the outflow tract is unlikely to drive the flow in that region. Conclusions: We present an imaging-based approach that enables localized assessment of pumping dynamics in the mouse tubular embryonic heart. This method creates a new opportunity for functional analysis of the pumping mechanism underlying the developing mammalian heart at early stages and could be useful for studying biomechanical changes in mutant embryonic hearts that model congenital heart defects.

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Proceedings Article | 2 April 2020 Presentation

Functional optical coherence tomography for investigation of embryonic development in vivo in mice (Conference Presentation)

Irina Larina

Proceedings Volume 11363, 1136309 (2020) https://doi.org/10.1117/12.2555311

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Proceedings Article | 9 March 2020 Presentation

Controlling the embryonic heart beat through optogenetics (Conference Presentation)

Andrew Lopez, Irina Larina

Proceedings Volume 11239, 112390V (2020) https://doi.org/10.1117/12.2554349

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Proceedings Article | 9 March 2020 Presentation

Biomechanical analysis of the embryonic mouse heart by optogenetic control (Conference Presentation)

Andrew Lopez, Shang Wang, Irina Larina

Proceedings Volume 11215, 112150J (2020) https://doi.org/10.1117/12.2548853

KEYWORDS: Heart, Optogenetics, Biological research, Harmonic generation, Collagen, Modulators, In vivo imaging, Integration, Pulsed laser operation, Optical coherence tomography

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Proceedings Article | 9 March 2020 Presentation

OCT analysis of mouse reproduction and early development in vivo: dynamics of cilia, eggs and sperm (Conference Presentation)

Irina Larina

Proceedings Volume 11239, 112390U (2020) https://doi.org/10.1117/12.2555061

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Proceedings Article | 24 February 2020 Paper

Quantitative 4D OCT imaging of tubular mouse embryonic heart reveals its localized pumping mechanism

Shang Wang, Riana Syed, Irina Larina

Proceedings Volume 11239, 112390A (2020) https://doi.org/10.1117/12.2553962

KEYWORDS: Heart, Blood circulation, Optical coherence tomography, Hemodynamics, Doppler effect, Imaging systems, Biomedical engineering, Physiology

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Proceedings Article | 7 March 2019 Presentation

Optical coherence tomography, optogenetic control, and second harmonic generation microscopy for investigation of embryonic cardiodynamics (Conference Presentation)

Andrew Lopez, Shang Wang, Irina Larina

Proceedings Volume 10855, 108550L (2019) https://doi.org/10.1117/12.2514608

KEYWORDS: Heart, Optogenetics, Optical coherence tomography, Harmonic generation, Microscopy, In vivo imaging, Coherence imaging, Collagen, Modulators, 3D image processing

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Proceedings Article | 4 March 2019 Presentation

In vivo imaging of mammalian reproductive events with functional optical coherence tomography (Conference Presentation)

Shang Wang, Emma Moore, Riana Syed, Irina Larina

Proceedings Volume 10877, 108770G (2019) https://doi.org/10.1117/12.2514609

KEYWORDS: Optical coherence tomography, In vivo imaging, 3D image processing, In vitro testing, Tissues, Visualization, Biology

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Proceedings Article | 22 February 2019 Paper

Optical coherence elastography reveals the changes in cardiac tissue biomechanical properties after myocardial infarction in a mouse model

Manmohan Singh, Shang Wang, Chih-Hao Liu, John Leach, Justin Rippy, Irina Larina, James Martin, Kirill Larin

Proceedings Volume 10867, 108672B (2019) https://doi.org/10.1117/12.2511524

KEYWORDS: Tissues, Tissue optics, Anisotropy, Coherence (optics), Elastography, Heart, Mouse models, Biological research, Wave propagation, Therapeutics

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Proceedings Article | 21 February 2019 Paper

Assessment of the biomechanical changes in cardiac tissue after myocardial infarction with optical coherence elastography

Manmohan Singh, Shang Wang, Chih-Hao Liu, John Leach, Justin Rippy, Irina Larina, James Martin, Kirill Larin

Proceedings Volume 10880, 1088003 (2019) https://doi.org/10.1117/12.2510762

KEYWORDS: Tissues, Anisotropy, Tissue optics, Heart, Elastography, Therapeutics, Coherence (optics), Wave propagation, Biological research, Molecular mechanisms

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Proceedings Article | 26 February 2018 Presentation + Paper

Functional optical coherence tomography for live dynamic analysis of mouse embryonic cardiogenesis

Shang Wang, Andrew Lopez, Irina Larina

Proceedings Volume 10493, 104930C (2018) https://doi.org/10.1117/12.2292106

KEYWORDS: Optical coherence tomography, Heart, Blood circulation, Speckle, Doppler effect, Wave propagation, Blood, Speckle imaging, Imaging systems, Doppler tomography

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Blood flow, heart contraction, and tissue stiffness are important regulators of cardiac morphogenesis and function during embryonic development. Defining how these factors are integrated is critically important to advance prevention, diagnostics, and treatment of congenital heart defects. Mammalian embryonic development is taking place deep within the female body, which makes cardiodynamic imaging and analysis during early developmental stages in humans inaccessible. With thousands of mutant lines available and well-established genetic manipulation tools, mouse is a great model to understand how biomechanical factors are integrated with molecular pathways to regulate cardiac function and development. Dynamic imaging and quantitative analysis of the biomechanics of live mouse embryos have become increasingly important, which demands continuous advancements in imaging techniques and live assessment approaches. This has been one of the major drives to keep pushing the frontier of embryonic imaging for better resolution, higher speed, deeper penetration, and more diverse and effective contrasts. Optical coherence tomography (OCT) has played a significant role in addressing such demands, and its features in non-labeling imaging, 3D capability, a large working distance, and various functional derivatives allow OCT to cover a number of specific applications in embryonic imaging. Recently, our group has made several technical improvements in using OCT to probe the biomechanical aspects of live developing mouse embryos at early stages. These include the direct volumetric structural and functional imaging of the cardiodynamics, four-dimensional quantitative Doppler imaging and analysis of the cardiac blood flow, and fourdimensional blood flow separation from the cardiac wall tissue in the beating embryonic heart. Here, we present a short review of these studies together with brief descriptions of the previous work that demonstrate OCT as a valuable and useful imaging tool for the research in developmental cardiology.

Proceedings Article | 7 February 2018 Presentation + Paper

Live dynamic analysis of mouse embryonic cardiogenesis with functional optical coherence tomography

Andrew Lopez, Shang Wang, Irina Larina

Proceedings Volume 10472, 104720S (2018) https://doi.org/10.1117/12.2292104

KEYWORDS: Heart, Optical coherence tomography, Collagen, Second-harmonic generation, Visualization, Tissues, Biological research

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Proceedings Article | 8 February 2017 Paper

A dual-modality optical coherence tomography and selective plane illumination microscopy system for mouse embryonic imaging

Chen Wu, Shihao Ran, Henry Le, Manmohan Singh, Irina Larina, David Mayerich, Mary Dickinson, Kirill Larin

Proceedings Volume 10043, 100430L (2017) https://doi.org/10.1117/12.2252677

KEYWORDS: Optical coherence tomography, Microscopy, Coherence imaging, Optical imaging, Imaging systems, Tissue optics, Digital imaging, Animal model studies, Integrated optics, Image resolution, 3D image processing, Tissues, Stereoscopy, Scattering, Refractive index, Luminescence, Illumination engineering

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Proceedings Article | 8 February 2017 Presentation + Paper

Live dynamic analysis of the developing cardiovascular system in mice

Andrew Lopez, Shang Wang, Kirill Larin, Irina Larina

Proceedings Volume 10043, 100430Q (2017) https://doi.org/10.1117/12.2252694

KEYWORDS: Heart, Optical coherence tomography, Cardiovascular system, Blood circulation, Image processing, Computational modeling, 3D image processing, Optical imaging, Medicine, Tissues, Imaging systems, Doppler tomography, Biological research

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Proceedings Article | 9 March 2016 Paper

Mechanical characterization of the mouse diaphragm with optical coherence elastography reveals fibrosis-related change of direction-dependent muscle tissue stiffness

Shang Wang, James Loehr, Irina Larina, George Rodney, Kirill Larin

Proceedings Volume 9710, 97100P (2016) https://doi.org/10.1117/12.2211160

KEYWORDS: Tissues, Elastography, Wave propagation, Coherence (optics), Optical coherence tomography, Tissue optics, Genetics, Natural surfaces, Optical fibers, Biological research, Neodymium

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Proceedings Article | 9 March 2016 Paper

Comparison of rotational imaging optical coherence tomography and selective plane illumination microscopy for embryonic study

Chen Wu, Shihao Ran, Henry Le, Manmohan Singh, Irina Larina, David Mayerich, Mary Dickinson, Kirill Larin

Proceedings Volume 9716, 97160B (2016) https://doi.org/10.1117/12.2209147

KEYWORDS: Coherence imaging, Optical imaging, Optical coherence tomography, Microscopy, Image resolution, 3D image processing, Physiology, Luminescence, Imaging systems, Spatial resolution, Objectives

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Proceedings Article | 9 March 2016 Presentation + Paper

Three-dimensional imaging of the developing mouse female reproductive organs with optical coherence tomography

Jason Burton, Shang Wang, Richard Behringer, Irina Larina

Proceedings Volume 9716, 97160E (2016) https://doi.org/10.1117/12.2213202

KEYWORDS: Optical coherence tomography, Uterus, Ovary, In vivo imaging, Biology, Stereoscopy, 3D image processing, 3D modeling, Spatial resolution, Tissues, Confocal microscopy, Genetics

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Proceedings Article | 9 March 2016 Paper

Live dynamic OCT imaging of cardiac structure and function in mouse embryos with 43 Hz direct volumetric data acquisition

Shang Wang, Manmohan Singh, Andrew Lopez, Chen Wu, Raksha Raghunathan, Alexander Schill, Jiasong Li, Kirill Larin, Irina Larina

Proceedings Volume 9716, 971603 (2016) https://doi.org/10.1117/12.2210751

KEYWORDS: Optical coherence tomography, Heart, Data acquisition, Functional imaging, Mode locking, Speckle, Doppler tomography, Blood circulation, Cardiovascular magnetic resonance imaging, Animal model studies, Ultrafast imaging, Imaging systems, Laser sources, Motion analysis, 3D image processing

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Proceedings Article | 9 March 2016 Presentation + Paper

Live 4D optical coherence tomography for early embryonic mouse cardiac phenotyping

Andrew Lopez, Shang Wang, Kirill Larin, Paul Overbeek, Irina Larina

Proceedings Volume 9716, 971609 (2016) https://doi.org/10.1117/12.2212452

KEYWORDS: Optical coherence tomography, 3D image processing, Optical imaging, Image processing, Visualization, Image resolution, Heart, Genetics, Physiology, Molecular imaging, Medicine, Analytical research, Mouse models, Imaging systems, Molecular biology, Biology

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Proceedings Article | 29 February 2016 Paper

Functional optical coherence tomography for high-resolution mapping of cilia beat frequency in the mouse oviduct in vivo

Shang Wang, Jason Burton, Richard Behringer, Irina Larina

Proceedings Volume 9689, 96893R (2016) https://doi.org/10.1117/12.2210758

KEYWORDS: Optical coherence tomography, In vivo imaging, Functional imaging, Speckle, Microscopy, Breast, Reproductive system, Structural imaging, Tissues, Genetics, Imaging systems, Medicine, Mouse models

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SPIE Journal Paper | 5 February 2016 Open Access

Rotational imaging optical coherence tomography for full-body mouse embryonic imaging

Chen Wu, Narendran Sudheendran, Manmohan Singh, Irina Larina, Mary Dickinson, Kirill Larin

JBO, Vol. 21, Issue 02, 026002, (February 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.2.026002

KEYWORDS: Optical coherence tomography, Coherence imaging, 3D image processing, 3D acquisition, Glasses, Optical imaging, Signal attenuation, Image registration, Composites, Visualization

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SPIE Journal Paper | 21 September 2015 Open Access

Live four-dimensional optical coherence tomography reveals embryonic cardiac phenotype in mouse mutant

Shang Wang, Andrew Lopez, Kirill Larin, Paul Overbeek, Irina Larina

JBO, Vol. 20, Issue 09, 090501, (September 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.9.090501

KEYWORDS: Optical coherence tomography, Heart, Imaging systems, Statistical analysis, Visualization, 3D image processing, Medicine, Video, Blood circulation, Genetics

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Proceedings Article | 10 March 2015 Paper

Dynamic imaging of preimplantation embryos in the murine oviduct

Jason Burton, Shang Wang, Irina Larina

Proceedings Volume 9334, 933409 (2015) https://doi.org/10.1117/12.2079913

KEYWORDS: Optical coherence tomography, Ovary, Uterus, Imaging systems, Visualization, Tissues, 3D modeling, 3D image processing, Medicine, Biology

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Proceedings Article | 10 March 2015 Paper

Live dynamic imaging and analysis of developmental cardiac defects in mouse models with optical coherence tomography

Andrew Lopez, Shang Wang, Monica Garcia, Christian Valladolid, Kirill Larin, Irina Larina

Proceedings Volume 9334, 93340S (2015) https://doi.org/10.1117/12.2079951

KEYWORDS: Optical coherence tomography, Visualization, Mouse models, Image processing, 3D image reconstruction, Imaging systems, 3D acquisition, Carbon dioxide, Medicine, Molecular biology

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Proceedings Article | 6 March 2015 Paper

Quantitative shear wave imaging optical coherence tomography for noncontact mechanical characterization of myocardium

Shang Wang, Andrew Lopez, Yuka Morikawa, Ge Tao, Jiasong Li, Irina Larina, James Martin, Kirill Larin

Proceedings Volume 9327, 93270F (2015) https://doi.org/10.1117/12.2078376

KEYWORDS: Tissue optics, Tissues, Optical coherence tomography, Biomedical optics, Elastography, Coherence imaging, Coherence (optics), Imaging systems, Soft tissue optics, Heart

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Optical coherence elastography (OCE) is an emerging low-coherence imaging technique that provides noninvasive assessment of tissue biomechanics with high spatial resolution. Among various OCE methods, the capability of quantitative measurement of tissue elasticity is of great importance for tissue characterization and pathology detection across different samples. Here we report a quantitative OCE technique, termed quantitative shear wave imaging optical coherence tomography (Q-SWI-OCT), which enables noncontact measurement of tissue Young’s modulus based on the ultra-fast imaging of the shear wave propagation inside the sample. A focused air-puff device is used to interrogate the tissue with a low-pressure short-duration air stream that stimulates a localized displacement with the scale at micron level. The propagation of this tissue deformation in the form of shear wave is captured by a phase-sensitive OCT system running with the scan of the M-mode imaging over the path of the wave propagation. The temporal characteristics of the shear wave is quantified based on the cross-correlation of the tissue deformation profiles at all the measurement locations, and linear regression is utilized to fit the data plotted in the domain of time delay versus wave propagation distance. The wave group velocity is thus calculated, which results in the quantitative measurement of the Young’s modulus. As the feasibility demonstration, experiments are performed on tissuemimicking phantoms with different agar concentrations and the quantified elasticity values with Q-SWI-OCT agree well with the uniaxial compression tests. For functional characterization of myocardium with this OCE technique, we perform our pilot experiments on ex vivo mouse cardiac muscle tissues with two studies, including 1) elasticity difference of cardiac muscle under relaxation and contract conditions and 2) mechanical heterogeneity of the heart introduced by the muscle fiber orientation. Our results suggest the potential of using Q-SWI-OCT as an essential tool for nondestructive biomechanical evaluation of myocardium.

Proceedings Article | 2 March 2015 Paper

Probing myocardium biomechanics using quantitative optical coherence elastography

Shang Wang, Andrew Lopez, Yuka Morikawa, Ge Tao, Jiasong Li, Irina Larina, James Martin, Kirill Larin

Proceedings Volume 9312, 93121Z (2015) https://doi.org/10.1117/12.2078390

KEYWORDS: Tissue optics, Optical coherence tomography, Tissues, Biomedical optics, Coherence (optics), Soft tissue optics, Elastography, Wave propagation, Heart, Coherence imaging

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SPIE Journal Paper | 12 January 2015 Open Access

Optical coherence tomography guided microinjections in live mouse embryos: high-resolution targeted manipulation for mouse embryonic research

Saba Syed, Andrew Coughlin, Monica Garcia, Shang Wang, Jennifer West, Kirill Larin, Irina Larina

JBO, Vol. 20, Issue 05, 051020, (January 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.5.051020

KEYWORDS: Optical coherence tomography, Gold, Silica, Imaging systems, Blood, 3D image processing, Spatial resolution, Heart, Blood vessels, Stereoscopy

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Proceedings Article | 4 March 2014 Paper

Enhancing imaging depth by multi-angle imaging of embryonic structures

Narendran Sudheendran, Chen Wu, Mary Dickinson, Irina Larina, Kirill Larin

Proceedings Volume 8953, 895306 (2014) https://doi.org/10.1117/12.2045529

KEYWORDS: Optical coherence tomography, Imaging systems, 3D image processing, Glasses, 3D acquisition, Ultrasonography, Stereoscopy, Image resolution, Magnetic resonance imaging, Projection systems

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Proceedings Article | 4 March 2014 Paper

Mouse embryo manipulations with OCT guidance

Monica Garcia, Saba Syed, Andrew Coughlin, Shang Wang, Jennifer West, Kirill Larin, Irina Larina

Proceedings Volume 8953, 89530K (2014) https://doi.org/10.1117/12.2045989

KEYWORDS: Optical coherence tomography, Tissues, Visualization, Imaging systems, Gold, Optical imaging, Target designation, 3D image processing, Interferometry, Cardiovascular system

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Proceedings Article | 4 March 2014 Paper

Rotational imaging OCT for full-body embryonic imaging

Narendran Sudheendran, Chen Wu, Irina Larina, Mary Dickinson, Kirill Larin

Proceedings Volume 8934, 89342K (2014) https://doi.org/10.1117/12.2041990

KEYWORDS: Optical coherence tomography, Glasses, Tissues, Image resolution, 3D image processing, Tissue optics, Signal attenuation, Image enhancement, Structural imaging, Information visualization

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Proceedings Article | 26 March 2013 Paper

In utero monitoring of mouse embryonic eye development with optical coherence tomography

Narendran Sudheendran, Maleeha Mashiatulla, Saba Syed, Mary Dickinson, Irina Larina, Kirill Larin

Proceedings Volume 8567, 856717 (2013) https://doi.org/10.1117/12.2005985

KEYWORDS: Eye, Optical coherence tomography, Tissues, Image resolution, Biomedical optics, Tissue optics, Coherence imaging, Eye models, Magnetic resonance imaging, Computed tomography

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Proceedings Article | 26 March 2013 Paper

OCT guided microinjections for mouse embryonic research

Kirill Larin, Saba Syed, Andrew Coughlin, Shang Wang, Jennifer West, Mary Dickinson, Irina Larina

Proceedings Volume 8593, 85930E (2013) https://doi.org/10.1117/12.2006213

KEYWORDS: Optical coherence tomography, Gold, Signaling molecules, Transplantation, Animal model studies, Medical research, Mouse models, Visualization, Biomedical optics, Optical fiber cables

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SPIE Journal Paper | 14 May 2012 Open Access

Optical coherence tomography for live phenotypic analysis of embryonic ocular structures in mouse models

Irina Larina, Saba Syed, Mary Dickinson, Kirill Larin, Narendran Sudheendran, Paul Overbeek

JBO, Vol. 17, Issue 8, 081410, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.8.081410

KEYWORDS: Optical coherence tomography, Eye, Mouse models, Imaging systems, Biological research, Eye models, Tissues, Visualization, Tumors, Vitreous

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Proceedings Article | 30 January 2012 Paper

Prenatal imaging of distal limb abnormalities using OCT in mice

Irina Larina, Saba Syed, Mary Dickinson, Paul Overbeek, Kirill Larin

Proceedings Volume 8213, 82130B (2012) https://doi.org/10.1117/12.909266

KEYWORDS: Optical coherence tomography, Bone, Cartilage, Optical lithography, Stereoscopy, 3D modeling, Biomedical optics, Mouse models, Molecular biology, Image processing

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SPIE Journal Paper | 1 April 2011 Open Access

Optical coherence tomography for high-resolution imaging of mouse development in utero

Saba Syed, Kirill Larin, Mary Dickinson, Irina Larina

JBO, Vol. 16, Issue 04, 046004, (April 2011) https://doi.org/10.1117/12.10.1117/1.3560300

KEYWORDS: Optical coherence tomography, Cartilage, Visualization, Brain, Ultrasonography, Image resolution, Bone, Spatial resolution, Imaging systems, Neuroimaging

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Proceedings Article | 12 February 2011 Paper

In utero imaging of mouse embryonic development with optical coherence tomography

Saba Syed, Mary Dickinson, Kirill Larin, Irina Larina

Proceedings Volume 7889, 78890A (2011) https://doi.org/10.1117/12.874963

KEYWORDS: Optical coherence tomography, Animal model studies, 3D modeling, Visualization, Spatial resolution, Uterus, Brain, Biomedical optics, Genetics, Ultrasonography

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Proceedings Article | 12 February 2011 Paper

In utero mouse embryonic imaging with OCT for ophthalmologic research

Saba Syed, Irina Larina, Mary Dickinson, Kirill Larin

Proceedings Volume 7885, 788508 (2011) https://doi.org/10.1117/12.875075

KEYWORDS: Optical coherence tomography, Eye, Structural imaging, Visualization, Mouse models, Eye models, Tissues, Biological research, 3D modeling, Biomedical optics

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Proceedings Article | 3 March 2010 Paper

Imaging of mouse embryonic eye development using optical coherence tomography

Saba Syed, Alyssa Kasiraj, Irina Larina, Mary Dickinson, Kirill Larin

Proceedings Volume 7550, 75501A (2010) https://doi.org/10.1117/12.842332

KEYWORDS: Eye, Optical coherence tomography, Visualization, Cornea, Mouse models, Tissues, Genetics, Spatial resolution, Opacity, Eye models

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SPIE Journal Paper | 1 September 2009 Open Access

Live imaging of rat embryos with Doppler swept-source optical coherence tomography

Irina Larina, Kenryo Furushima, Mary Dickinson, Richard Behringer, Kirill Larin

JBO, Vol. 14, Issue 05, 050506, (September 2009) https://doi.org/10.1117/12.10.1117/1.3241044

KEYWORDS: Optical coherence tomography, Heart, Doppler tomography, Doppler effect, 3D image processing, 3D modeling, Imaging systems, Physiology, Blood circulation, Genetics

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Proceedings Article | 20 February 2009 Paper

Enhanced OCT imaging of embryonic tissue with optical clearing

Irina Larina, Esteban Carbajal, Valery Tuchin, Mary Dickinson, Kirill Larin

Proceedings Volume 7168, 71682C (2009) https://doi.org/10.1117/12.808055

KEYWORDS: Optical coherence tomography, Tissues, Tissue optics, Optical clearing, Refractive index, Scattering, Light scattering, Diffusion, Natural surfaces, Collagen

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Proceedings Article | 19 February 2009 Paper

Imaging of cardiovascular dynamics in early mouse embryos with swept source optical coherence tomography

Irina Larina, Michael Liebling, Mary Dickinson, Kirill Larin

Proceedings Volume 7168, 71680E (2009) https://doi.org/10.1117/12.807984

KEYWORDS: Heart, Optical coherence tomography, Blood circulation, Confocal microscopy, Plasma, Tissues, Interferometers, Doppler tomography, Temporal resolution, Ultrasonography

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SPIE Journal Paper | 1 November 2008 Open Access

Live imaging of blood flow in mammalian embryos using Doppler swept-source optical coherence tomography

Irina Larina, N. Sudheendran, Mohamad Ghosn, James Jiang, Alex Cable, Kirill Larin, Mary Dickinson

JBO, Vol. 13, Issue 06, 060506, (November 2008) https://doi.org/10.1117/12.10.1117/1.3046716

KEYWORDS: Blood circulation, Optical coherence tomography, Heart, Doppler tomography, Doppler effect, Hemodynamics, Confocal microscopy, Structural imaging, 3D image processing, Physiology

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Proceedings Article | 7 May 2007 Paper

On the way to subcellular imaging of mechanotransduction in the developing vasculature

Irina Larina, Yingxiao Wang, Shu Chien, Mary Lane, Mary Dickinson

Proceedings Volume 6535, 653504 (2007) https://doi.org/10.1117/12.740602

KEYWORDS: Fluorescence resonance energy transfer, In vivo imaging, Luminescence, Sensors, Heart, Fluorescent proteins, Blood circulation, In vitro testing, Tissues, Biophysics

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Proceedings Article | 20 August 2004 Paper

Optical coherence tomography and noninvasive blood glucose monitoring: a review

Kirill Larin, Taras Ashitkov, Irina Larina, Irina Petrova, Mohsen Eledrisi, Massoud Motamedi, Rinat Esenaliev

Proceedings Volume 5474, (2004) https://doi.org/10.1117/12.578965

KEYWORDS: Glucose, Optical coherence tomography, Blood, Skin, Mie scattering, Scattering, Tissues, Lithium, Biophysics, Tissue optics

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Proceedings Article | 14 June 2002 Paper

Optical coherence tomography technique for noninvasive blood glucose monitoring: phantom, animal, and human studies

Kirill Larin, Taras Ashitkov, Irina Larina, Irina Petrova, Mohsen Eledrisi, Massoud Motamedi, Rinat Esenaliev

Proceedings Volume 4619, (2002) https://doi.org/10.1117/12.470478

KEYWORDS: Glucose, Optical coherence tomography, Blood, Scattering, Tissues, Mie scattering, Skin, Tissue optics, Light scattering, Ear

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Proceedings Article | 9 July 2001 Paper

Cavitation-induced drug delivery in tumors for cancer chemotherapy: animal studies

Rinat Esenaliev, Irina Larina, Yuliana Ivanova, Taras Ashitkov, Robert Thomas, B. Evers

Proceedings Volume 4257, (2001) https://doi.org/10.1117/12.434726

KEYWORDS: Tumors, Cancer, Cavitation, Particles, Ultrasonography, Colorectal cancer, Blood, Colon, Microscopy, Blood vessels

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Proceedings Article | 9 July 2001 Paper

Cavitation-induced drug delivery in tumors for cancer chemotherapy: phantom studies

Irina Larina, Christian Bartels, Kirill Larin, Rinat Esenaliev

Proceedings Volume 4257, (2001) https://doi.org/10.1117/12.434724

KEYWORDS: Cavitation, Particles, Tumors, Cancer, Carbon, Cerium, Tissues, Pulsed laser operation, Ultrasonography, Blood

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Proceedings Article | 15 June 2001 Paper

Comparison of optoacoustic tomography with ultrasound and x-ray imaging for breast cancer detection

Kirill Larin, O. Hartrumpf, Irina Larina, Rinat Esenaliev

Proceedings Volume 4256, (2001) https://doi.org/10.1117/12.429301

KEYWORDS: Tumors, Ultrasonography, Breast, Breast cancer, X-ray imaging, X-rays, Tissues, Tomography, Transducers, Tissue optics

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Proceedings Article | 13 June 2001 Paper

Potential application of optical coherence tomography for noninvasive monitoring of glucose concentration

Kirill Larin, Irina Larina, Massoud Motamedi, Valentin Gelikonov, Roman Kuranov, Rinat Esenaliev

Proceedings Volume 4263, (2001) https://doi.org/10.1117/12.429342

KEYWORDS: Glucose, Optical coherence tomography, Blood, Scattering, Tissues, Skin, In vivo imaging, Tissue optics, Mie scattering, Near infrared

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Proceedings Article | 13 June 2000 Paper

Mechanism of laser-induced drug delivery in tumors

Rinat Esenaliev, Irina Larina, Kirill Larin, Massoud Motamedi, B. Evers

Proceedings Volume 3914, (2000) https://doi.org/10.1117/12.388045

KEYWORDS: Tumors, Cavitation, Particles, Cancer, Microscopy, Tissues, Ultrasonics, Carbon, Laser irradiation, Pulsed laser operation

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Proceedings Article | 19 May 2000 Paper

Monitoring of temperature distribution in tissues with optoacoustic technique in real time

Kirill Larin, Irina Larina, Massoud Motamedi, Rinat Esenaliev

Proceedings Volume 3916, (2000) https://doi.org/10.1117/12.386336

KEYWORDS: Tissues, Temperature metrology, Liver, Transducers, Pulsed laser operation, Signal attenuation, Heat therapy, Natural surfaces, Absorption, Diffuse reflectance spectroscopy

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Proceedings Article | 19 May 2000 Paper

Real-time optoacoustic monitoring during thermotherapy

Rinat Esenaliev, Irina Larina, Kirill Larin, Massoud Motamedi

Proceedings Volume 3916, (2000) https://doi.org/10.1117/12.386334

KEYWORDS: Tissues, Tissue optics, Optical properties, Liver, Heat therapy, Temperature metrology, Liquids, Nitrogen, Diffuse reflectance spectroscopy, Nd:YAG lasers

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Proceedings Article | 6 April 2000 Paper

Optoacoustic monitoring of freezing and hypothermia of tissue and tissue phantoms

Irina Larina, Kirill Larin, Massoud Motamedi, Rinat Esenaliev

Proceedings Volume 4001, (2000) https://doi.org/10.1117/12.381528

KEYWORDS: Tissues, Liver, Temperature metrology, Tissue optics, Liquids, Transducers, Ultrasonography, Acoustics, Nitrogen, Magnetic resonance imaging

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Proceedings Article | 14 June 1999 Paper

Real-time optoacoustic monitoring of temperature in tissues

Rinat Esenaliev, Alexander Oraevsky, Kirill Larin, Irina Larina, Massoud Motamedi

Proceedings Volume 3601, (1999) https://doi.org/10.1117/12.350008

KEYWORDS: Tissues, Temperature metrology, Liver, Transducers, Heat therapy, Acoustics, Pulsed laser operation, Quartz, Optical properties, Imaging spectroscopy

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Proceedings Article | 19 May 1999 Paper

Laser optoacoustic technique for real-time measurement of thermal damage in tissues

Rinat Esenaliev, Irina Larina, Kirill Larin, Massoud Motamedi, Alexander Karabutov, Alexander Oraevsky

Proceedings Volume 3594, (1999) https://doi.org/10.1117/12.348727

KEYWORDS: Tissues, Liver, Signal attenuation, Optical properties, Prostate, Nd:YAG lasers, Transducers, Acoustics, Continuous wave operation, Temperature metrology

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Proceedings Article | 4 March 1999 Paper

Optical properties of normal and coagulated tissues: measurements using combination of optoacoustic and diffuse reflectance techniques

Rinat Esenaliev, Kirill Larin, Irina Larina, Massoud Motamedi, Alexander Oraevsky

Proceedings Volume 3726, (1999) https://doi.org/10.1117/12.341443

KEYWORDS: Tissues, Diffuse reflectance spectroscopy, Absorption, Liver, Scattering, Signal attenuation, Optical properties, Photodiodes, Acoustics, Optical testing

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