Model-based estimation of breast percent density in raw and processed full-field digital mammography images from image-acquisition physics and patient-image characteristics

Brad M. Keller; Diane L. Nathan; Emily F. Conant; Despina Kontos

doi:10.1117/12.912368

2 March 2012 Model-based estimation of breast percent density in raw and processed full-field digital mammography images from image-acquisition physics and patient-image characteristics

Brad M. Keller, Diane L. Nathan, Emily F. Conant, Despina Kontos

Author Affiliations +

Proceedings Volume 8313, Medical Imaging 2012: Physics of Medical Imaging; 83130K (2012) https://doi.org/10.1117/12.912368
Event: SPIE Medical Imaging, 2012, San Diego, California, United States

Abstract

Breast percent density (PD%), as measured mammographically, is one of the strongest known risk factors for breast cancer. While the majority of studies to date have focused on PD% assessment from digitized film mammograms, digital mammography (DM) is becoming increasingly common, and allows for direct PD% assessment at the time of imaging. This work investigates the accuracy of a generalized linear model-based (GLM) estimation of PD% from raw and postprocessed digital mammograms, utilizing image acquisition physics, patient characteristics and gray-level intensity features of the specific image. The model is trained in a leave-one-woman-out fashion on a series of 81 cases for which bilateral, mediolateral-oblique DM images were available in both raw and post-processed format. Baseline continuous and categorical density estimates were provided by a trained breast-imaging radiologist. Regression analysis is performed and Pearson's correlation, r, and Cohen's kappa, κ, are computed. The GLM PD% estimation model performed well on both processed (r=0.89, p<0.001) and raw (r=0.75, p<0.001) images. Model agreement with radiologist assigned density categories was also high for processed (κ=0.79, p<0.001) and raw (κ=0.76, p<0.001) images. Model-based prediction of breast PD% could allow for a reproducible estimation of breast density, providing a rapid risk assessment tool for clinical practice.

Citation Download Citation

Brad M. Keller, Diane L. Nathan, Emily F. Conant, and Despina Kontos "Model-based estimation of breast percent density in raw and processed full-field digital mammography images from image-acquisition physics and patient-image characteristics", Proc. SPIE 8313, Medical Imaging 2012: Physics of Medical Imaging, 83130K (2 March 2012); https://doi.org/10.1117/12.912368

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