Neuronal activation and ballistic cellular dynamics by phase-sensitive optical coherence microscopy

Honggu Choi; Rishyashring R. Iyer; Carlos A. Renteria; Brian Tibble; Mantas Žurauskas; Stephen A. Boppart

doi:10.1117/12.2609753

28 April 2022 Neuronal activation and ballistic cellular dynamics by phase-sensitive optical coherence microscopy

Honggu Choi, Rishyashring R. Iyer, Carlos A. Renteria, Brian Tibble, Mantas Žurauskas, Stephen A. Boppart

Proceedings Volume PC11946, Neural Imaging and Sensing 2022; PC119460E (2022) https://doi.org/10.1117/12.2609753
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

The anomalous diffusion characteristics of neuronal dynamics are analyzed by label-free, phase-sensitive optical coherence microscopy. The technique provides low-noise images, enabling cellular dynamic characteristics to be measurable. The phase variance is a conventional dynamic parameter that cannot elucidate the ballistic components of neuronal dynamics. Determining the dynamics by phase variance alone omits the ballistic information that can occur from the ion exchange across cellular membranes. The probability density function of phase displacements exerted by cellular dynamics was acquired and the shape of the power-law tail was analyzed. The development of the power-law tail provides a more sensitive dynamic feature.

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Honggu Choi, Rishyashring R. Iyer, Carlos A. Renteria, Brian Tibble, Mantas Žurauskas, and Stephen A. Boppart "Neuronal activation and ballistic cellular dynamics by phase-sensitive optical coherence microscopy", Proc. SPIE PC11946, Neural Imaging and Sensing 2022, PC119460E (28 April 2022); https://doi.org/10.1117/12.2609753

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KEYWORDS

Optical coherence microscopy

Neurons

Diffusion

Ion exchange

Signal to noise ratio

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