High-density diffuse optical tomography imaging of cortical network response to deep brain stimulation for essential tremor

Monalisa Munsi; Arefeh Sherafati; Adam T. Eggebrecht; Tracy M. Burns-Yocum; Heather M. Lugar; Anagha Narayanan; Tasha Doty; Sarah A. Eisenstein; Alexandra M. Svoboda; Mariel L. Schroeder; Abraham Z. Snyder; Mwiza Ushe; Joseph P. Culver; Tamara Hershey

doi:10.1117/12.2610039

28 April 2022 High-density diffuse optical tomography imaging of cortical network response to deep brain stimulation for essential tremor

Monalisa Munsi, Arefeh Sherafati, Adam T. Eggebrecht, Tracy M. Burns-Yocum, Heather M. Lugar, Anagha Narayanan, Tasha Doty, Sarah A. Eisenstein, Alexandra M. Svoboda, Mariel L. Schroeder, Abraham Z. Snyder, Mwiza Ushe, Joseph P. Culver, Tamara Hershey

Author Affiliations +

Proceedings Volume PC11946, Neural Imaging and Sensing 2022; PC119460P (2022) https://doi.org/10.1117/12.2610039
Event: SPIE BiOS, 2022, San Francisco, California, United States

Abstract

Deep-brain stimulation (DBS) of the ventro-intermediate nucleus of the thalamus (VIM) can provide substantial clinical motor benefit to Essential Tremor (ET) patients. However, the DBS impact on the functional connectivity (FC) of networks is difficult to study using standard neuroimaging modalities either due to limited temporal resolution (PET) or safety concerns from contraindications (fMRI). In this study, we tested the feasibility and sensitivity of High-Density Diffuse Optical Tomography (HD-DOT), which avoids these concerns, for mapping cortical blood flow responses to sensory stimuli and measuring resting state cortical FC in ET patients with VIM DBS OFF vs ON.

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Monalisa Munsi, Arefeh Sherafati, Adam T. Eggebrecht, Tracy M. Burns-Yocum, Heather M. Lugar, Anagha Narayanan, Tasha Doty, Sarah A. Eisenstein, Alexandra M. Svoboda, Mariel L. Schroeder, Abraham Z. Snyder, Mwiza Ushe, Joseph P. Culver, and Tamara Hershey "High-density diffuse optical tomography imaging of cortical network response to deep brain stimulation for essential tremor", Proc. SPIE PC11946, Neural Imaging and Sensing 2022, PC119460P (28 April 2022); https://doi.org/10.1117/12.2610039

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