Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.

Julien Bec; Xiangnan Zhou; Pelham Keahey; Martin Villiger; Brett Bouma; Laura Marcu

doi:10.1117/12.2649672

17 March 2023 Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.

Julien Bec, Xiangnan Zhou, Pelham Keahey, Martin Villiger, Brett Bouma, Laura Marcu

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Proceedings Volume PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023; PC1235505 (2023) https://doi.org/10.1117/12.2649672
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

We report the development and characterization of a multispectral FLIm/ polarization-sensitive OCT intravascular imaging catheter system. This system targets the improved characterization of two key contributors to atherosclerosis disease development: inflammation and disruption of the extracellular matrix, by enabling the evaluation of biochemical signature, birefringence, and depolarization in addition to lesion morphology. We present key aspects of the system’s design and performance and highlight challenges associated with the development of intravascular imaging systems suitable for clinical translation.

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Julien Bec, Xiangnan Zhou, Pelham Keahey, Martin Villiger, Brett Bouma, and Laura Marcu "Demonstration of a combined multispectral FLIm/ polarization-sensitive OCT catheter system for biochemical/structural evaluation of atherosclerosis lesions.", Proc. SPIE PC12355, Diagnostic and Therapeutic Applications of Light in Cardiology 2023, PC1235505 (17 March 2023); https://doi.org/10.1117/12.2649672

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KEYWORDS

Optical coherence tomography

Imaging devices

Imaging systems

Multispectral imaging

Polarization

Optical fibers

Pathogens

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