Paired-agent imaging for the rapid and accurate detection of involved margins in Mohs micrographic surgery

Veronica Torres; Rachel Chacko; Sassan Hodge; Joshua Levy; Louis Vaickus; Eunice Chen; Matthew LeBoeuf; Kimberley S. Samkoe

doi:10.1117/12.2651021

17 March 2023 Paired-agent imaging for the rapid and accurate detection of involved margins in Mohs micrographic surgery

Veronica Torres, Rachel Chacko, Sassan Hodge, Joshua Levy, Louis Vaickus, Eunice Chen, Matthew LeBoeuf, Kimberley S. Samkoe

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Proceedings Volume PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX; PC123610G (2023) https://doi.org/10.1117/12.2651021
Event: SPIE BiOS, 2023, San Francisco, California, United States

Abstract

Fluorescence paired-agent imaging (PAI) is presented as a method to rapidly screen en face margins during Mohs surgery to reduce the time required for pathological assessment of intraoperative frozen tissue sections. PAI was applied to mouse models of squamous cell carcinoma, and positive tumor burden was detected using both the mean and maximum signal intensity. It was determined that PAI BP had higher tumor detection accuracy as compared to single-agent fluorescence, while the en face margins provided detailed visualization of the tumor burden. PAI is a promising methodology for rapidly screening positive margins during Mohs surgery.

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Veronica Torres, Rachel Chacko, Sassan Hodge, Joshua Levy, Louis Vaickus, Eunice Chen, Matthew LeBoeuf, and Kimberley S. Samkoe "Paired-agent imaging for the rapid and accurate detection of involved margins in Mohs micrographic surgery", Proc. SPIE PC12361, Molecular-Guided Surgery: Molecules, Devices, and Applications IX, PC123610G (17 March 2023); https://doi.org/10.1117/12.2651021

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KEYWORDS

Mohs surgery

Surgery

Tumors

Skin cancer

Luminescence

Receptors

Signal detection

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