Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy

Leilei Zhang; Jeff S. Xu; Virgil E. Sanders; Alan D. Letson; Cynthia J. Roberts; Ronald X. Xu

doi:10.1117/1.3457669

1 May 2010 Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy

Leilei Zhang, Jeff S. Xu, Virgil E. Sanders, Alan D. Letson, Cynthia J. Roberts, Ronald X. Xu

Author Affiliations +

Journal of Biomedical Optics, Vol. 15, Issue 3, 030515 (May 2010). https://doi.org/10.1117/1.3457669

Abstract

We synthesize multifunctional microbubbles (MBs) for targeted delivery of antivascular endothelial growth factor (antiVEGF) therapy with multimodal imaging guidance. Poly-lactic-co-glycolic acid (PLGA) MBs encapsulating Texas Red dye are fabricated by a modified double-emulsion process. Simultaneous ultrasound and fluorescence imaging are achieved using Texas Red encapsulated MBs. The MBs are conjugated with Avastin, an antiVEGF antibody for treating neovascular age-related macular degeneration (AMD). The conjugation efficiency is characterized by enzyme-linked immunosorbent assay (ELISA). The efficiency for targeted binding of Avastin-conjugated MBs is characterized by microscopic imaging. Our work demonstrates the technical potential of using multifunctional MBs for targeted delivery of antiVEGF therapy in the treatment of exudative AMD.

©(2010) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Leilei Zhang, Jeff S. Xu, Virgil E. Sanders, Alan D. Letson, Cynthia J. Roberts, and Ronald X. Xu "Multifunctional microbubbles for image-guided antivascular endothelial growth factor therapy," Journal of Biomedical Optics 15(3), 030515 (1 May 2010). https://doi.org/10.1117/1.3457669

Published: 1 May 2010

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KEYWORDS

Luminescence

Ultrasonography

Multimodal imaging

Imaging systems

Optical coherence tomography

Scanning electron microscopy

Chlorine

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