Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing

Rajan Arora; Georgi I. Petrov; Vladislav V. Yakovlev; Jian Liu

doi:10.1117/1.3533317

1 February 2011 Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing

Rajan Arora, Georgi I. Petrov, Vladislav V. Yakovlev, Jian Liu

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Journal of Biomedical Optics, Vol. 16, Issue 2, 021114 (February 2011). https://doi.org/10.1117/1.3533317

Abstract

Nonlinear Raman microspectroscopy based on a broadband coherent anti-Stokes Raman scattering is an emerging technique for noninvasive, chemically specific, microscopic analysis of tissues and large population of cells and particles. The sensitivity of this imaging is a critical aspect of a number of the proposed biomedical application. It is shown that the incident laser power is the major parameter controlling this sensitivity. By careful optimizing the laser system, the high-quality vibrational spectra acquisition at the multi-kHz rate becomes feasible.

©(2011) Society of Photo-Optical Instrumentation Engineers (SPIE)

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Rajan Arora, Georgi I. Petrov, Vladislav V. Yakovlev, and Jian Liu "Improving sensitivity in nonlinear Raman microspectroscopy imaging and sensing," Journal of Biomedical Optics 16(2), 021114 (1 February 2011). https://doi.org/10.1117/1.3533317

Published: 1 February 2011

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