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2 September 2016 Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis
Basanta Bhaduri, Ryan M. Nolan, Ryan L. Shelton, Lara A. Pilutti, Robert W. Motl, Stephen A. Boppart
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Journal of Biomedical Optics, Vol. 21, Issue 9, 095001 (September 2016). https://doi.org/10.1117/1.JBO.21.9.095001
Abstract
We performed ratiometric analysis of retinal optical coherence tomography images for the first time in multiple sclerosis (MS) patients. The ratiometric analysis identified differences in several retinal layer thickness ratios in the cohort of MS subjects without a history of optic neuritis (ON) compared to healthy control (HC) subjects, and there was no difference in standard retinal nerve fiber layer thickness (RNFLT). The difference in such ratios between HC subjects and those with mild MS-disability, without a difference in RNFLT, further suggests the possibility of using layer ratiometric analysis for detecting early retinal changes in MS. Ratiometric analysis may be useful and potentially more sensitive for detecting disease changes in MS.
© 2016 Society of Photo-Optical Instrumentation Engineers (SPIE) 1083-3668/2016/$25.00 © 2016 SPIE
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Basanta Bhaduri, Ryan M. Nolan, Ryan L. Shelton, Lara A. Pilutti, Robert W. Motl, and Stephen A. Boppart "Ratiometric analysis of in vivo retinal layer thicknesses in multiple sclerosis," Journal of Biomedical Optics 21(9), 095001 (2 September 2016). https://doi.org/10.1117/1.JBO.21.9.095001
Published: 2 September 2016
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Cited by 3 scholarly publications and 1 patent.
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KEYWORDS
Optical coherence tomography
Image segmentation
In vivo imaging
Biological research
Statistical analysis
Visualization
Nerve
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