High-grade gliomas (HGG) are the most common and most aggressive primary tumors of the brain. Despite recent advances in neuro-oncology survival of these tumors remains around 12-15 months. The first-line of treatment is surgical resection. However, due to its infiltrative nature maximal safe resection leaves residual invasive cancer cells that lead to disease recurrence. The vast majority of recurrences are in or near the resection cavity. Advances in optical imaging techniques might aid better delineation of the invasive margin intraoperatively. However as of yet most of these technologies have failed to do so consistently. Recently, alterations in fatty acid metabolism have been linked to the initiation, progression, and recurrence of gliomas. These alterations might provide a novel target for better differentiation of glioma cells and healthy brain tissue. To exploit this, we introduce and test a novel, near-infrared, fluorescent dye, fatty-acid indocyanine green (FA-ICG) in vitro and in vivo. We hypothesize that the combination of targeting mechanism, and the near-infrared properties make FA-ICG a promising candidate for further clinical translation in fluorescence-guided surgery.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.