The presence of microgravity and ionizing radiation during spaceflight missions causes excessive Reactive Oxygen Species (ROS) production that contributes to oxidative cellular stress and multifunctional damage in astronauts. This knowledge has underlined the importance of frequent monitoring of astronaut’s health to have early diagnoses. In this scenario, the biosensor diagnostic devices could offer the necessary analytical performance to study pathological astronaut conditions. Herein, we propose an innovative biosensor for detecting highly diluted biomarkers at picogram level by using the pyro-electrohydrodynamic jet (p-jet) system. The detection limit of the system was confirmed using a model protein as the Bovine Serum Albumin (BSA) by optimizing its deposition on different functionalized glass substrates through different chemical reactions starting with a manual procedure. Based on these results, the epoxy glass activated surface was chosen as the best slide for p-jet experiments. The characterization of the processes was performed through different spectroscopic techniques such as infrared-spectroscopy (IR) or confocal fluorescence. In the context of long-term human missions, our revolutionary approach could be extremely useful to monitor the astronaut health.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.