Dr. Ilona Kuzmina Profile

Dr. Ilona Kuzmina

Lead Researcher at Univ of Latvia

SPIE Involvement:

Author | Editor

Publications (31)

SPIE Journal Paper | 16 September 2022 Open Access

Three-dimensional representation of triple spectral line imaging data as an option for noncontact skin diagnostics

Ilze Ošina, Janis Spigulis, Ilona Kuzmina, Laura Dambite, Anna Berzina

JBO, Vol. 27, Issue 09, 095005, (September 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.9.095005

KEYWORDS: Skin, Pathology, Chromophores, 3D image processing, 3D modeling, Signal attenuation, Melanoma, Diagnostics, RGB color model, Tumor growth modeling

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Significance: Skin malformations in dermatology are mostly evaluated subjectively, based on a doctor’s experience and visual perception; an option for objective quantitative skin assessment is camera-based spectrally selective diagnostics. Multispectral imaging is a technique capable to provide information about concentrations of the absorbing chromophores and their distribution over the malformation in a noncontact way. Conversion of spectral images into distribution maps of chromophores can be performed by means of the modified Beer–Lambert law. However, such distribution maps represent only single specific cases, therefore, some extensive method for data comparison is needed.Aim: This study aims to develop a more informative approach for identification and characterization of skin malformations using three-dimensional (3D) representation of triple spectral line imaging data.Approach: The 3D-representation method is experimentally tested on eight different skin pathology types, including both benign and malignant pathologies; an imaging device ensuring uniform three laser line (448, 532, and 659 nm) illumination is used. Three spectral line images are extracted from a single snapshot RGB image data, with subsequent calculation of attenuation coefficients for each working wavelength at every image pixel and represented as 3D graphs. Skin chromophore content variations in malformations are represented in a similar way.Results: Clinical measurement results for 99 skin pathologies, including basal cell carcinomas, melanoma, dermal nevi, combined nevi, junctional nevi, blue nevi, seborrheic keratosis, and hemangiomas. They are presented as 3D spectral attenuation maps exhibiting specific individual features for each group of pathologies. Along with intensity attenuation maps, 3D maps for content variations of three main skin chromophores (melanin, oxyhemoglobin, and deoxyhemoglobin), calculated in frame of a model based on modified Beer–Lambert law, are also presented. Advantages and disadvantages of the proposed data representation method are discussed.Conclusions: The described 3D-representation method of triple spectral line imaging data shows promising potential for objective quantitative noncontact diagnosis of skin pathologies.

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SPIE Journal Paper | 21 February 2022 Open Access

Skin chromophore mapping by smartphone RGB camera under spectral band and spectral line illumination

Ilona Kuzmina, Ilze Oshina, Laura Dambite, Vanesa Lukinsone, Anna Maslobojeva, Anna Berzina, Janis Spigulis

JBO, Vol. 27, Issue 02, 026004, (February 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.2.026004

KEYWORDS: Skin, Light emitting diodes, Prototyping, Chromophores, RGB color model, Cameras, Photons, Fiber optic illuminators, Image processing, Diagnostics

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Significance: Multispectral imaging enables mapping of chromophore content changes in skin neoplasms, which helps to diagnose a pathology. Different types of light sources can be used for the imaging. Design of laser-based illuminators is more complicated and, consequently, they are more expensive than LED-based illuminators. On the other hand, spectral line illumination has the advantage of less complicated calculations, since only the discrete maximum wavelengths need to be considered. Spectral band and spectral line approaches for multispectral skin diagnostics have not been compared so far. This can help to evaluate the accuracy and effectiveness of both approaches. Aim: To compare two specific illumination modalities—spectral band and spectral line illumination—from the point of performance for mapping of in vivo skin chromophores. Approach: Three spectral images of the same skin malformations were captured by a smartphone RGB camera with two different add-on illuminators comprising LED emitters and laser emitters, respectively. Five types of benign skin neoplasms were included in our study. Concentrations of skin melanin, oxy- and deoxy-hemoglobin at image pixel groups were calculated using the Beer–Lambert law. Results: Skin chromophore maps and statistical analysis of mean concentrations’ changes in the neoplasms compared to the surrounding skin are presented and discussed. The data of the laser emitters led to significantly higher (∼10 times) increase of the oxy-hemoglobin values in vascular neoplasms and much lower deoxy-hemoglobin values, if compared to the data obtained by the LED emitters. Conclusions: Analysis of the obtained chromophore distribution maps and concentration variations in neoplasms led to conclusion that the spectral line illumination approach is more appropriate for this application. Considering only the peak wavelengths of illumination spectral bands leads to essentially different results if compared to those obtained by spectral line illumination and may cause misinterpretations in the clinical assessment of skin neoplasms.

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Proceedings Article | 28 October 2020 Paper

Biophotonics research in Riga: recent projects and results

Janis Spigulis, Ilona Kuzmina, Ilze Lihacova, Vanesa Lukinsone, Blaž Cugmas, Andris Grabovskis, Edgars Kviesis-Kipge, Alexey Lihachev

Proceedings Volume 11585, 1158502 (2020) https://doi.org/10.1117/12.2581799

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Proceedings Article | 20 August 2020 Presentation

Skin chromophore mapping from multi-spectral laser line images

Ilze Ošina, Ilona Kuzmina, Uldis Rubins, Vanesa Lukinsone, Anna Maslobojeva, Laura Dambite, Margarita Matulenko, Zigmars Rupenheits, Janis Spigulis

Proceedings Volume 11483, 114830A (2020) https://doi.org/10.1117/12.2568069

KEYWORDS: Skin, Chromophores, In vivo imaging, Diagnostics, Cancer, Skin cancer, Prototyping, Tissue optics, Light scattering, Wound healing

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Proceedings Article | 2 April 2020 Presentation + Paper

Remitted photon path length in human skin, skin phantoms and cell cultures

V. Lukinsone, I. Kuzmina, M. Tamosiunas, A. Maslobojeva, M. Kuzminskis, U. Rubins, J. Spigulis

Proceedings Volume 11363, 1136320 (2020) https://doi.org/10.1117/12.2555822

KEYWORDS: Skin, Tissues, Photon transport, Chromophores, Picosecond phenomena, Light scattering, Time correlated photon counting

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Proceedings Article | 2 April 2020 Presentation + Paper

Agar-based phantoms for skin diagnostic imaging

Ilona Kuzmina, Vanesa Lukinsone, Uldis Rubins, Ilze Osina, Laura Dambite, Anna Maslobojeva, Janis Spigulis

Proceedings Volume 11363, 113630F (2020) https://doi.org/10.1117/12.2555674

KEYWORDS: RGB color model, Skin, Prototyping, Absorption, Diffuse reflectance spectroscopy, Chromophores, Transmittance, Light emitting diodes, Optical properties, Scattering

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Proceedings Article | 17 February 2020 Paper

Towards combined multispectral, FLIM and Raman imaging for skin diagnostics

J. Spigulis, I. Kuzmina, V. Lukinsone, M. Tamošiūnas, I. Oshina, L. Ozolina, A. Maslobojeva, M. Kuzminskis, D. Ivanov, E. Borisova

Proceedings Volume 11232, 112320N (2020) https://doi.org/10.1117/12.2559107

KEYWORDS: Raman spectroscopy, Skin, Diagnostics, Multispectral imaging, Luminescence, Prototyping, Fluorescence lifetime imaging, Light emitting diodes, Cameras, RGB color model

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Proceedings Article | 22 July 2019 Paper

Towards direct measurements of remitted photon path lengths in skin: kinetic studies in the range 520-800 nm

V. Lukinsone, M. Osis, J. Latvels, I. Kuzmina, U. Rubins, N. Zorina, A. Maslobojeva, J. Spigulis

Proceedings Volume 11075, 1107505 (2019) https://doi.org/10.1117/12.2526663

KEYWORDS: Skin, Signal detection, Picosecond phenomena, Absorption, Tissues, Chromophores, Neodymium, Scattering, Data processing, Tissue optics

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Proceedings Article | 3 June 2019 Paper

Multispectral and autofluorescence RGB imaging for skin cancer diagnostics

V. Lukinsone, I. Kuzmina, R. Veilande, E. V. Plorina, D. Bliznuks, K. Bolochko, A. Derjabo, I. Lihacova, J. Spigulis

Proceedings Volume 11065, 110650A (2019) https://doi.org/10.1117/12.2518882

KEYWORDS: Skin, Melanoma, Diagnostics, Multispectral imaging, Diffuse reflectance spectroscopy, Light emitting diodes, RGB color model, Skin cancer, Image processing, Cameras

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Proceedings Article | 29 January 2019 Paper

Multispectral autoflourescence detection of skin neoplasia using steady-state techniques

Ekaterina Borisova, Alexander Gisbrecht, Tsanislava Genova-Hristova, Petranka Troyanova, Elmira Pavlova, Nikolay Penkov, Ivan Bratchenko, Valery Zakharov, Ilze Lihachova, Ilona Kuzmina, Janis Spigulis

Proceedings Volume 11047, 1104704 (2019) https://doi.org/10.1117/12.2516337

KEYWORDS: Tissues, Skin, Luminescence, Fluorescence spectroscopy, Collagen, Pathology, Diagnostics, Signal detection

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Proceedings Article | 7 December 2017 Paper

Image quality enhancement for skin cancer optical diagnostics

Dmitrijs Bliznuks, Ilona Kuzmina, Katrina Bolocko, Alexey Lihachev

Proceedings Volume 10592, 105920F (2017) https://doi.org/10.1117/12.2297579

KEYWORDS: Image filtering, Skin, Image quality, Diagnostics, Light emitting diodes, Skin cancer, Sensors, Biomedical optics

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Proceedings Article | 7 December 2017 Paper

Rosacea assessment by erythema index and principal component analysis segmentation maps

Ilona Kuzmina, Uldis Rubins, Inga Saknite, Janis Spigulis

Proceedings Volume 10592, 1059204 (2017) https://doi.org/10.1117/12.2285175

KEYWORDS: Image segmentation, Skin, RGB color model, Blood vessels, Principal component analysis, Image analysis, Image processing, Image processing algorithms and systems, Visualization, Biomedical optics

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Proceedings Article | 5 January 2017 Paper

Investigating different skin and gastrointestinal tract (GIT) pathologies ex vivo by autofluorescence spectroscopy and optical imaging

A. Zhelyazkova, I. Kuzmina, E. Borisova, N. Penkov, Ts. Genova, J. Spigulis, L. Avramov

Proceedings Volume 10226, 1022615 (2017) https://doi.org/10.1117/12.2261817

KEYWORDS: Imaging spectroscopy, Spectroscopy, Skin, Tissues, Tumors, Luminescence, Collagen, Diagnostics, Chromophores, Signal detection

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SPIE Journal Paper | 25 September 2015 Open Access

Study of smartphone suitability for mapping of skin chromophores

Ilona Kuzmina, Matiss Lacis, Janis Spigulis, Anna Berzina, Lauma Valeine

JBO, Vol. 20, Issue 09, 090503, (September 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.9.090503

KEYWORDS: Skin, Chromophores, RGB color model, Cameras, In vitro testing, Light emitting diodes, In vivo imaging, Light sources, Galactic astronomy, Diagnostics

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SPIE Journal Paper | 20 December 2013 Open Access

Noncontact monitoring of vascular lesion phototherapy efficiency by RGB multispectral imaging

Dainis Jakovels, Ilona Kuzmina, Anna Berzina, Lauma Valeine, Janis Spigulis

JBO, Vol. 18, Issue 12, 126019, (December 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.12.126019

KEYWORDS: Skin, RGB color model, Phototherapy, Imaging systems, Multispectral imaging, Absorption, Laser therapeutics, Cameras, Polarizers, Optical inspection

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Proceedings Article | 18 November 2013 Paper

Application of principal component analysis to multispectral imaging data for evaluation of pigmented skin lesions

Dainis Jakovels, Ilze Lihacova, Ilona Kuzmina, Janis Spigulis

Proceedings Volume 9032, 903204 (2013) https://doi.org/10.1117/12.2044383

KEYWORDS: Principal component analysis, Skin, Melanoma, Multispectral imaging, Diagnostics, Neodymium, Ions, Skin cancer, Imaging systems, Directed energy weapons

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Proceedings Article | 24 June 2013 Paper

Evaluation of skin melanoma in spectral range 450-950 nm using principal component analysis

D. Jakovels, I. Lihacova, I. Kuzmina, J. Spigulis

Proceedings Volume 8803, 88030C (2013) https://doi.org/10.1117/12.2032526

KEYWORDS: Skin, Melanoma, Principal component analysis, Absorbance, Image analysis, Multispectral imaging, RGB color model, Diagnostics, Biomedical optics, Skin cancer

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Proceedings Article | 8 May 2012 Paper

Analysis of skin basalioma and melanoma by multispectral imaging

I. Diebele, A. Bekina, A. Derjabo, J. Kapostinsh, I. Kuzmina, J. Spigulis

Proceedings Volume 8427, 842732 (2012) https://doi.org/10.1117/12.922301

KEYWORDS: Melanoma, Skin, Multispectral imaging, Absorbance, Pathology, Absorption, Blood, Cameras, Image processing, Clinical trials

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Proceedings Article | 8 May 2012 Paper

RGB imaging system for monitoring of skin vascular malformation's laser therapy

Dainis Jakovels, Ilona Kuzmina, Anna Berzina, Janis Spigulis

Proceedings Volume 8427, 842737 (2012) https://doi.org/10.1117/12.922432

KEYWORDS: Skin, RGB color model, Laser therapeutics, Imaging systems, Chromophores, Cameras, Absorbance, Laser damage threshold, Reflectivity, Quantitative analysis

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Proceedings Article | 15 June 2011 Paper

Melanoma-nevus differentiation by multispectral imaging

Ilze Diebele, Ilona Kuzmina, Janis Kapostinsh, Alexander Derjabo, Janis Spigulis

Proceedings Volume 8087, 80872G (2011) https://doi.org/10.1117/12.889697

KEYWORDS: Melanoma, Skin, Multispectral imaging, Absorbance, Cameras, Diagnostics, Imaging spectroscopy, Oncology, Image processing, RGB color model

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SPIE Journal Paper | 1 June 2011 Open Access

Towards noncontact skin melanoma selection by multispectral imaging analysis

Ilona Kuzmina, Ilze Diebele, Dainis Jakovels, Janis Spigulis, Lauma Valeine, Janis Kapostinsh, Anna Berzina

JBO, Vol. 16, Issue 06, 060502, (June 2011) https://doi.org/10.1117/12.10.1117/1.3584846

KEYWORDS: Skin, Melanoma, Chromophores, Multispectral imaging, Absorbance, Pathology, RGB color model, Light scattering, Lamps, Image processing

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SPIE Journal Paper | 1 April 2011 Open Access

Contact and contactless diffuse reflectance spectroscopy: potential for recovery monitoring of vascular lesions after intense pulsed light treatment

Ilona Kuzmina, Ilze Diebele, Janis Spigulis, Lauma Valeine, Anna Berzina, Anita Abelite

JBO, Vol. 16, Issue 04, 040505, (April 2011) https://doi.org/10.1117/12.10.1117/1.3569119

KEYWORDS: Skin, Multispectral imaging, Diffuse reflectance spectroscopy, Absorption, Absorbance, Diagnostics, Optical fibers, Near infrared, Sensors, Inspection

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Proceedings Article | 18 February 2011 Paper

Multi-spectral imaging analysis of pigmented and vascular skin lesions: results of a clinical trial

Ilona Kuzmina, Ilze Diebele, Lauma Valeine, Dainis Jakovels, Anna Kempele, Janis Kapostinsh, Janis Spigulis

Proceedings Volume 7883, 788312 (2011) https://doi.org/10.1117/12.887207

KEYWORDS: Skin, Melanoma, Chromophores, Pathology, Clinical trials, Absorbance, Diagnostics, RGB color model, Multispectral imaging, Lamps

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Proceedings Article | 25 November 2010 Paper

Multispectral imaging of pigmented and vascular cutaneous malformations: the influence of laser treatment

Ilona Kuzmina, Ilze Diebele, Lasma Asare, Anna Kempele, Anita Abelite, Dainis Jakovels, Janis Spigulis

Proceedings Volume 7376, 73760J (2010) https://doi.org/10.1117/12.873701

KEYWORDS: Skin, Laser therapeutics, Multispectral imaging, Polarizers, Cameras, Signal detection, Light emitting diodes, Argon ion lasers, Absorbance, Nd:YAG lasers

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Proceedings Article | 25 January 2007 Paper

Compact multi-functional skin spectrometry set-up

Ilona Kuzmina, Alexey Lihachev, Lasma Gailite, Janis Spigulis

Proceedings Volume 6596, 65960T (2007) https://doi.org/10.1117/12.726455

KEYWORDS: Skin, Diffuse reflectance spectroscopy, Spectroscopy, Luminescence, Blood, Fluorescence spectroscopy, Absorption, Tissue optics, Sensors, Reflection

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Proceedings Article | 13 June 2006 Paper

Bragg and asymmetric-relief reflection gratings in As-S-Se thin films

Ilona Kuzmina, Janis Teteris

Proceedings Volume 5946, 59461G (2006) https://doi.org/10.1117/12.639187

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Proceedings Article | 26 August 2004 Paper

Amorphous chalcogenide thin films as a media for holographic recording

Mara Reinfelde, Janis Teteris, Ilona Kuzmina

Proceedings Volume 5566, (2004) https://doi.org/10.1117/12.577583

KEYWORDS: Holography, Diffraction gratings, Refractive index, Diffraction, Chalcogenides, Thin films, Absorption, Etching, Reflection, Prisms

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Proceedings Article | 19 November 2003 Paper

Holographic recording optimization in amorphous As-Se-S films

Mara Reinfelde, Janis Teteris, Ilona Kuzmina

Proceedings Volume 4829, (2003) https://doi.org/10.1117/12.526991

KEYWORDS: Holography, Holograms, Diffraction, Holographic optical elements, Amorphous semiconductors, Chalcogenides, Thin films, Wet etching, Diffraction gratings, Infrared radiation

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Proceedings Article | 8 August 2003 Paper

Relief holographic recording in amorphous As-S-Se

Ilona Kuzmina, Janis Teteris, Mara Reinfelde

Proceedings Volume 5123, (2003) https://doi.org/10.1117/12.517015

KEYWORDS: Diffraction, Holography, Diffraction gratings, Etching, Thin films, Holograms, Helium neon lasers, Amorphous semiconductors, Photoresist materials, Beam splitters

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Proceedings Article | 8 August 2003 Paper

Amorphous As-S-Se films for holographic recording

Mara Reinfelde, Janis Teteris, Ilona Kuzmina

Proceedings Volume 5123, (2003) https://doi.org/10.1117/12.517013

KEYWORDS: Holography, Diffraction, Diffraction gratings, Fiber Bragg gratings, Refractive index, Thin films, Holograms, Reflection, Absorption, Volume holography

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Proceedings Article | 10 April 2001 Paper

Amorphous chalcogenide semiconductor resists for holography and electron-beam lithography

Janis Teteris, Ilona Kuzmina

Proceedings Volume 4415, (2001) https://doi.org/10.1117/12.425513

KEYWORDS: Holography, Diffraction, Holograms, Etching, Chalcogenides, Amorphous semiconductors, Semiconductors, Diffraction gratings, Electron beam lithography, Lithography

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Showing 5 of 31 publications

Proceedings Volume Editor (1)

SPIE Conference Volume | 18 November 2013

Biophotonics—Riga 2013

Conference Committee Involvement (1)

Biophotonics-Riga 2013

26 August 2013 | Riga, Latvia

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