Surface-enhanced Raman scattering (SERS) has extended its biomedical application to in vivo preclinical imaging. However, the in vivo SERS imaging requires non-clearable large gold nanoparticles, limiting their translation in humans.
Here, we address this problem by creating SERS supraparticles composed of small-sized nanoclusters. First, we performed the FDTD simulation of the supraparticle design, and the maximum enhancement factor of 10^6 was achieved. Second, we chemically synthesized bright supraparticles that enabled in vivo Raman imaging of rodent models. Furthermore, the supraparticles were highly excretable, offering great potential for clinical application of in vivo Raman imaging by replacing non-excretable SERS nanotags.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.