The object of the study was an aqueous dispersion of gold nanoparticles stabilized with polyvinyl alcohol (AuPVA). It was previously found that AuPVA is characterized by a broad spectrum of antimicrobial activity against standard and clinical strains of gram-positive and gram-negative bacteria and yeasts. The safety of using AuPVA is associated with the absence of toxic effects of its working concentrations on biotest objects and cell cultures. Evaluation of the effectiveness of photodynamic antimicrobial therapy was carried out on a model of experimental full-sleep purulent wounds, which were formed in the interscapular region in rats. We used a semiconductor laser with a wavelength of 405 nm (manufactured by AlcomMedica, St. Petersburg). It was found that the use of 1% aqueous dispersion of AuPVA as a photosensitizer led to a 1,6-fold reduction in the wound healing time compared to the control.
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