Dr. Nicholas L. Everdell Profile

Dr. Nicholas L. Everdell

at Univ College London

SPIE Involvement:

Author

Publications (19)

Proceedings Article | 9 December 2021 Paper

Evaluating a new generation of wearable high-density diffuse optical tomography (HD-DOT) technology via retinotopic mapping in the adult brain

Ernesto Vidal-Rosas, Hubin Zhao, Reuben Nixon-Hill, Greg Smith, Luke Dunne, Samuel Powell, Robert Cooper, Nicholas Everdell

Proceedings Volume 11920, 1192019 (2021) https://doi.org/10.1117/12.2615354

KEYWORDS: 3D modeling, Brain mapping, Visualization, Brain, Hemodynamics, Head, Diffuse optical tomography, Positron emission tomography, Functional magnetic resonance imaging, 3D image processing

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Proceedings Article | 9 December 2021 Paper

ANIMATE: wearable, flexible, and ultra-lightweight high-density diffuse optical tomography technologies for functional neuroimaging of newborns

Hubin Zhao, Elisabetta Maria Frijia, Ernesto Vidal Rosas, Liam Collins-Jones, Greg Smith, Reuben Nixon-Hill, Samuel Powell, Nicholas Everdell, Robert Cooper

Proceedings Volume 11920, 119201A (2021) https://doi.org/10.1117/12.2615357

KEYWORDS: Neuroimaging, Diffuse optical tomography, Connectors, Sensors, Imaging arrays, Mechanical engineering, Light emitting diodes, Imaging systems, Absorbance, Traumatic brain injury

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Proceedings Article | 9 December 2021 Paper

Towards cot-side mapping of the sensorimotor cortex in preterm and term infants with wearable high-density diffuse optical tomography

Elisabetta Maria Frijia, Hubin Zhao, Liam Collins-Jones, Greg Smith, Nicholas Everdell, Topun Austin, Robert Cooper

Proceedings Volume 11920, 119201C (2021) https://doi.org/10.1117/12.2615363

KEYWORDS: Sensors, Sensorimotor cortex, Diffuse optical tomography, Data modeling, Brain mapping, Brain, 3D acquisition, Video, Spatial resolution, Silicon

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SPIE Journal Paper | 9 April 2021 Open Access

Evaluating a new generation of wearable high-density diffuse optical tomography technology via retinotopic mapping of the adult visual cortex

Ernesto Vidal-Rosas, Hubin Zhao, Reuben Nixon-Hill, Greg Smith, Luke Dunne, Samuel Powell, Robert Cooper, Nicholas Everdell

NPh, Vol. 8, Issue 02, 025002, (April 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.2.025002

KEYWORDS: Diffuse optical tomography, Visualization, Neurophotonics, Visual cortex, Head, Brain, Hemodynamics, 3D modeling, Signal to noise ratio, Imaging systems

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SPIE Journal Paper | 26 March 2021 Open Access

Design and validation of a mechanically flexible and ultra-lightweight high-density diffuse optical tomography system for functional neuroimaging of newborns

Hubin Zhao, Elisabetta Frijia, Ernesto Vidal Rosas, Liam Collins-Jones, Greg Smith, Reuben Nixon-Hill, Samuel Powell, Nicholas Everdell, Robert Cooper

NPh, Vol. 8, Issue 01, 015011, (March 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015011

KEYWORDS: Neuroimaging, Imaging systems, Connectors, Absorption, Sensors, Neurophotonics, Brain, Absorbance, Optical properties, Near infrared

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Significance: Neonates are a highly vulnerable population. The risk of brain injury is greater during the first days and weeks after birth than at any other time of life. Functional neuroimaging that can be performed longitudinally and at the cot-side has the potential to improve our understanding of the evolution of multiple forms of neurological injury over the perinatal period. However, existing technologies make it very difficult to perform repeated and/or long-duration functional neuroimaging experiments at the cot-side. Aim: We aimed to create a modular, high-density diffuse optical tomography (HD-DOT) technology specifically for neonatal applications that is ultra-lightweight, low profile and provides high mechanical flexibility. We then sought to validate this technology using an anatomically accurate dynamic phantom. Approach: An advanced 10-layer rigid-flexible printed circuit board technology was adopted as the basis for the DOT modules, which allows for a compact module design that also provides the flexibility needed to conform to the curved infant scalp. Two module layouts were implemented: dual-hexagon and triple-hexagon. Using in-built board-to-board connectors, the system can be configured to provide a vast range of possible layouts. Using epoxy resin, thermochromic dyes, and MRI-derived 3D-printed moulds, we constructed an electrically switchable, anatomically accurate dynamic phantom. This phantom was used to quantify the imaging performance of our flexible, modular HD-DOT system. Results: Using one particular module configuration designed to cover the infant sensorimotor system, the device provided 36 source and 48 detector positions, and over 700 viable DOT channels per wavelength, ranging from 10 to ∼45 mm over an area of approximately 60 cm2. The total weight of this system is only 70 g. The signal changes from the dynamic phantom, while slow, closely simulated real hemodynamic response functions. Using difference images obtained from the phantom, the measured 3D localization error provided by the system at the depth of the cortex was in the of range 3 to 6 mm, and the lateral image resolution at the depth of the neonatal cortex is estimated to be as good as 10 to 12 mm. Conclusions: The HD-DOT system described is ultra-low weight, low profile, can conform to the infant scalp, and provides excellent imaging performance. It is expected that this device will make functional neuroimaging of the neonatal brain at the cot-side significantly more practical and effective.

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Proceedings Article | 8 March 2021 Presentation

Wearable high-density diffuse optical tomography (HDDOT) for unrestricted 3D functional neuroimaging

Ernesto Vidal-Rosas, Rueben Hill, Greg Smith, Hubin Zhao, Samuel Powell, Nick Everdell, Robert Cooper

Proceedings Volume 11629, 116291R (2021) https://doi.org/10.1117/12.2583161

KEYWORDS: Diffuse optical tomography, Neuroimaging, Imaging systems, Visualization, Brain imaging

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Proceedings Article | 11 July 2019 Paper

Advances in wearable high-density diffuse optical tomography: first applications of a new commercial technology and development of an infant-specific research device

Hubin Zhao, Sabrina Brigadoi, Reuben Hill, Greg Smith, Luke Dunne, Elisabetta Maria Frijia, Samuel Powell, Nick Everdell, Robert Cooper

Proceedings Volume 11074, 1107403 (2019) https://doi.org/10.1117/12.2526976

KEYWORDS: Diffuse optical tomography, Brain, Neuroimaging, Hemodynamics, Optical fibers, Imaging systems, Near infrared spectroscopy, Light emitting diodes, Photodiodes

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SPIE Journal Paper | 12 May 2016 Open Access

Errata: Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

Maria Chalia, Chuen Wai Lee, Laura Dempsey, Andrea Edwards, Harsimrat Singh, Andrew Michell, Nicholas Everdell, Reuben Hill, Jeremy Hebden, Topun Austin, Robert Cooper

NPh, Vol. 3, Issue 03, 039802, (May 2016) https://doi.org/10.1117/12.10.1117/1.NPh.3.3.039802

KEYWORDS: Hemodynamics, Electroencephalography, Biomedical optics, Roads, Video, Medical physics, Biomedical engineering, Neurophysiology, Neurophotonics

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SPIE Journal Paper | 2 May 2016 Open Access

Hemodynamic response to burst-suppressed and discontinuous electroencephalography activity in infants with hypoxic ischemic encephalopathy

Maria Chalia, Chuen Wai Lee, Laura Dempsey, Andrea Edwards, Harsimrat Singh, Andrew Michell, Nicholas Everdell, Reuben Hill, Jeremy Hebden, Topun Austin, Robert Cooper

NPh, Vol. 3, Issue 03, 031408, (May 2016) https://doi.org/10.1117/12.10.1117/1.NPh.3.3.031408

KEYWORDS: Electroencephalography, Hemodynamics, Brain, Data modeling, Neurophotonics, Electrodes, Diffuse optical tomography, Oxygen, Video, Injuries

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Proceedings Article | 16 July 2015 Paper

Whole-head functional brain imaging of neonates at cot-side using time-resolved diffuse optical tomography

Laura Dempsey, Robert Cooper, Samuel Powell, Andrea Edwards, Chuen-Wai Lee, Sabrina Brigadoi, Nick Everdell, Simon Arridge, Adam Gibson, Topun Austin, Jeremy Hebden

Proceedings Volume 9538, 953818 (2015) https://doi.org/10.1117/12.2190420

KEYWORDS: Head, Image restoration, Sensors, Brain, Diffuse optical tomography, Scattering, Tissues, Photons, Data acquisition, Hemodynamics

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Proceedings Article | 9 March 2015 Paper

Measurement of contrast of phantom and in vivo subsurface blood vessels using two near-infrared imaging systems

Jeremy Hebden, Aysha Alkhaja, Laure Mahe, S. Powell, N. Everdell

Proceedings Volume 9332, 933213 (2015) https://doi.org/10.1117/12.2084673

KEYWORDS: Blood vessels, Absorption, Veins, Visualization, Tissues, Imaging systems, Near infrared, Natural surfaces, Image processing, Signal attenuation

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Proceedings Article | 8 May 2012 Paper

Simultaneous EEG and diffuse optical imaging of seizure-related hemodynamic activity in the newborn infant brain

Jeremy Hebden, Robert Cooper, Adam Gibson, Nick Everdell, Topun Austin

Proceedings Volume 8427, 84271N (2012) https://doi.org/10.1117/12.922990

KEYWORDS: Electroencephalography, Hemodynamics, Brain, Head, Imaging systems, Sensors, Control systems, Diffuse optical imaging, Neuroimaging, Optical imaging

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Proceedings Article | 10 July 2009 Paper

Multispectral imaging of the ocular fundus using LED illumination

N. Everdell, I. Styles, E. Claridge, J. Hebden, A. Calcagni

Proceedings Volume 7371, 73711C (2009) https://doi.org/10.1117/12.831769

KEYWORDS: Light sources, Microscopes, Imaging systems, Multispectral imaging, Light emitting diodes, Cameras, LED lighting, Chromophores, Image quality, Eye

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Proceedings Article | 8 October 2005 Paper

3D optical tomography of the neonatal brain

A. Gibson, T. Austin, N. Everdell, J. Meek, J. Wyatt, M. Schweiger, S. Arridge, D. Delpy, J. Hebden

Proceedings Volume 5859, 58590E (2005) https://doi.org/10.1117/12.632834

KEYWORDS: Optical tomography, Head, Brain, Blood, 3D image processing, Absorption, Ultrasonography, Neuroimaging, Traumatic brain injury, Oxygen

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SPIE Journal Paper | 1 September 2005 Open Access

Time-resolved optical mammography using a liquid coupled interface

Tara Yates, Jeremy Hebden, Adam Gibson, Louise Enfield, Nicholas Everdell, Simon Arridge, David Delpy

JBO, Vol. 10, Issue 05, 054011, (September 2005) https://doi.org/10.1117/12.10.1117/1.2063327

KEYWORDS: Breast, Sensors, Liquids, Mammography, Optical properties, Scattering, Spatial resolution, Absorption, Tissues, Optical tomography

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Proceedings Article | 28 April 2005 Paper

Multi-dimensional time-correlated single photon counting applied to diffuse optical tomography

Wolfgang Becker, Axel Bergmann, Adam Gibson, Nick Everdell, David Jennions, M. Schweiger, S. Arridge, Jeremy Hebden

Proceedings Volume 5693, (2005) https://doi.org/10.1117/12.589004

KEYWORDS: Sensors, Photons, Picosecond phenomena, Multiplexing, Luminescence, Absorption, Diffuse optical tomography, Tissue optics, Signal detection, Single photon

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Proceedings Article | 29 July 2003 Paper

Validation of the use of homogeneous reference phantoms for optical tomography of the neonatal brain

Rozarina Yusof, Jeremy Hebden, Adam Gibson, Nick Everdell, Topun Austin, Judith Meek, Simon Arridge, John Wyatt, David Delpy

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478137

KEYWORDS: Head, Brain, Scattering, 3D image processing, Optical tomography, Absorption, Optical properties, Data acquisition, Sensors, Refractive index

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Proceedings Article | 29 July 2003 Paper

Functional imaging of the brain using a portable NIR instrument

Tharshan Vaithianathan, Iain Tullis, Nicholas Everdell, Terence Leung, Judith Meek, David Delpy

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478168

KEYWORDS: Light emitting diodes, Photodiodes, Palladium, Sensors, Near infrared, Brain, Optical amplifiers, Silicon, Head, Neuroimaging

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SPIE Journal Paper | 1 January 2003 Open Access

Assessment of in situ temporal calibration method for time-resolved optical tomography

Jeremy Hebden, Felipe Gonzalez, Adam Gibson, Elizabeth Hillman, Rozarina Md Yusof, Nick Everdell, David Delpy, Giovanni Zaccanti, Fabrizio Martelli

JBO, Vol. 8, Issue 01, (January 2003) https://doi.org/10.1117/12.10.1117/1.1528206

KEYWORDS: Calibration, Sensors, Connectors, Picosecond phenomena, Optical properties, Tissue optics, Data modeling, Photons, Monte Carlo methods, Natural surfaces

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