We propose a highly efficient Surface Plasmon Resonance (SPR)-based sensing device to detect various anaemic conditions in human blood. A thin aluminum (Al) metal-coated glass prism is used to excite surface plasmons. A high-dielectric constant material, TiO2, is used over Al-metal to enhance the sensitivity, and a layer of fluorinated graphene (FG) is used as a bio-recognition element to study biomolecular interactions. To demonstrate sensing application, an Al (30 nm)-based engineered plasmonic device with an optimized value of TiO2 (2nm) and functionalized with an FG layer is utilized to detect various hemoglobin (Hb) concentrations in human blood at a wavelength of 1550 nm. A value of sensitivity of 123 °/RIU and FOM 439 RIU-1 is observed for the proposed Al-TiO2-FG-based SPR sensor. The proposed sensing device can be used as a biosensor to detect anemia by accurately evaluating the level of Hb concentration, making it the best candidate for biomedical applications.
We present a high-quality factor plasmonic biosensor with a metal-2D material-metal (M-2D-M) structure for dengue detection. The modified prism-based plasmonic sensor consists of two layers of aluminum (Al) (30 nm and 7 nm) sandwiching a layer of 2D nanomaterial (MoS2). Each layer of the proposed plasmonic device is engineered using the transfer matrix method, considering critical performance parameters such as sensitivity, quality factor, detection accuracy, and Figure of Merit (FOM). The effect of different 2D nanomaterial layers, e.g., antimonene, black phosphorus, graphene, MXene, and molybdenum disulfide (MoS2), on the sensing parameters is studied in the M-2D-M structure. A monolayer of MoS2 is considered at the top of the M-2D-M structure as a bio-recognition element to study biomolecular interactions. The final plasmonic multilayer structure, Al-MoS2-Al-MoS2, is used for dengue detection by capturing the variation in different blood components, such as plasma, platelets, and hemoglobin, in normal and infected states.
Dielectric and metallic metasurfaces are proposed to demonstrate the sensing applications in the near-infrared region under normal incidence light. The geometrical parameters of the proposed metasurfaces are designed using Rigorous coupled analysis under wavelength interrogation, and the results are verified using Comsol Multiphysics software. A layer of 2D nanomaterial (MoS2) is considered to increase the adsorption on the sensing surface. Aluminum-based metallic metasurfaces offer a sensitivity of 1100nm/RIU with a figure of merit of 250 RIU-1. The proposed metasurfaces are further used for the detection of cancer cells in human blood, and a red shift in the wavelength spectra is observed due to the increase in the refractive index.
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