Nanoimprint lithography is the simple method using stamp and UV or thermal curable resins for nano-structures/patterns with low cost, high-throughput, and high resolution. Residual-layer free NIL provides good performance of micro/nano-scale structures functional arrangements with 2/3D layouts. We demonstrated nanohole patterns of 200 nm pore size using residual-layer-free NIL without further process for removing residual layers for reflectance biosensor. The reflectance peaks of gold substrate are enhanced to 8 times using the hexagonal hole patterns of diameter 200 nm, and pitch 400 nm. So, this substrate can be applied for immune reflectance biosensor with magnetic nanoparticles for pre-treatment.
Surface-enhanced Raman spectroscopy (SERS) has enormous potential as a highly sensitive (to a single-molecular level) and molecular-specific analytical technique for biological imaging and sensing. For the reliable SERS sensing, fabrication of metal nanostructures bundle patterns with multiple narrow nano-gaps over the homogenous macroscale is important pre-requisite due to their enhanced properties. Unfortunately, the fabrication of dense and uniform nano-gaps without organic materials is rather difficult since they usually have required complicated and a number of synthetic steps. In this research, we propose a facile and efficient methodology for manipulation of nano-gap densities inside Ag bundle patterns (ABPs) by controlling the Ag nanostructure size over a large area. Especially, we successfully demonstrate the fabrication of high-density small nano-gaps (about 2.5 nm) between silver nanostructure array patterns. We generated uniform nano-hole patterns over the entire substrate through nano-imprint lithography and silver nanostructures were deposited via electrodeposition. The relative size of Ag nanostructure elements was controlled by the Ag precursor concentration. Finally, we fully demonstrate their application in the rapid detection of rhodamine 6G (R6G) molecules by SERS with a very low detection limit as well as excellent signal uniformity, indicating an extraordinary capability for single-molecule detection.
Access to the requested content is limited to institutions that have purchased or subscribe to SPIE eBooks.
You are receiving this notice because your organization may not have SPIE eBooks access.*
*Shibboleth/Open Athens users─please
sign in
to access your institution's subscriptions.
To obtain this item, you may purchase the complete book in print or electronic format on
SPIE.org.
INSTITUTIONAL Select your institution to access the SPIE Digital Library.
PERSONAL Sign in with your SPIE account to access your personal subscriptions or to use specific features such as save to my library, sign up for alerts, save searches, etc.