Glaucoma is characterized by the irreversible retinal ganglion cells (RGCs) loss and has received great research and clinical attention due to its complex mechanism and loss of effective treatment. Longitudinal in vivo study on glaucoma in mouse model can be a promising approach to unveil the mechanism of glaucoma. In this paper, we use a silicon oil (SO) induced glaucoma model on mouse and the adaptive optics two photon microscope system to evaluate whether the aberration from both mouse eye and SO can be corrected and then longitudinal imaging with subcellular resolution on the mouse retina can be achieved.
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