An improved simulation model of photon propagation in scattering biological tissue has been developed based on the Monte Carlo method, which makes it possible to comprehensively consider all the main optical processes occurring during the propagation of optical radiation through the BT. The model differs from the known ones in that it allows one to consider the polarization state of the incident radiation and the change in its optical characteristics by tracking the electric field in each interaction event. Based on the developed statistical model, simulation modeling of the processes of photon propagation in the skin and its individual layers was carried out, which made it possible to establish the scattering and transmission characteristics for each of the skin layers with model parameters considering the angles of incidence of radiation in the visible and near-IR ranges, and the thickness of the skin layers. The simulation also made it possible to determine the relative intensity of backscattered photons depending on localization.
The perspective of using the photoplethysmographic method for evaluating microcirculatory changes in tissue microcirculation to study the processes that occur during photon physiotherapeutic influence in the maxillofacial region is considered. Also, this research method is relevant for determining microcirculation disorders in patients with various degrees of severity of field injuries. 2. Photon radiation has been shown to increase the elasticity of blood vessel walls, elasticity of erythrocytes, oxygen transport function of blood, activity of cell membranes, acceleration of tissue regeneration processes, reduction of lipid oxidation, normalization of blood rheological parameters, stimulation of ATP formation in mitochondria, which increases the bioenergetic potential of cells.
The use of photoplethysmography allows an accurate assessment of the level of blood supply in inflammatory symptoms in patients with diabetes after tooth extraction, this method has the positive properties of non-invasiveness, high sensitivity and probabilistic ease of examination. Photon radiation has been shown to increase blood vessel wall elasticity, erythrocyte elasticity, blood oxygen transport function, cell membrane activity, accelerate tissue regeneration, reduce lipid oxidation, and normalize blood rheology. The photon radiation of the "MultiSpectr-001" multispectral physiotherapy device has been shown to lead to anti-inflammatory, desensitizing, analgesic, antispasmodic, anti-edema effects, which was confirmed in this study in the treatment of diabetic patients.
Main directions of the application of the mathematical methods in medical diagnosis are analyzed, their drawbacks are evaluated , principles of diagnosis, based on fuzzy logic are formulated. Mathematical models and algorithms, formalizing the process of diagnostic decisions making on the base of fuzzy logic at quantitative and qualitative parameters of the patient state are developed; mathematical models of the membership functions, formalizing the presentation of quantitative and qualitative parameters of the patients state in the form of the fuzzy sets, used in the models and algorithms of diagnosis and determining the diagnosis in case of diabetic ketoacidosis are developed. Aim of the study is realization of the computer-based expert system for the solution of the problems, dealing with medical diagnosis on the base of fuzzy logic in case of Diabetic Ketoacidosis
The given paper analyzes principles of interaction and analysis of the reflected optical radiation from biotissue
in the process of assessment of regional hemodynamics state in patients with local hypertensive- ischemic pain syndrome
of amputation stumps of lower extremities, applying the method of photoplethysmography.
The purpose is the evaluation of Laser photoplethysmography (LPPG) diagnostic value in examination of
patients with chronic ischemia of lower extremities. Photonic device is developed to determine the level of the peripheral
blood circulation, which determines the basic parameters of peripheral blood circulation and saturation level. Device
consists of two sensors: infrared sensor, which contains the infrared laser radiation source and photodetector, and red
sensor, which contains the red radiation source and photodetector. LPPG method allows to determined pulsatility of
blood flow in different areas of the foot and lower leg, the degree of compensation and conservation perspectives limb.
Surgical treatment of local hypertensive –ischemic pain syndrome of amputation stumps of lower extremities
by means of semiclosed fasciotomy in combination with revasculating osteotrepanation enabled to improve considerably
regional hemodynamics in the tissues of the stump and decrease pain and hypostatic disorders.
Remote photoplethysmography (PPG) imaging is an optical technique to remotely assess the local coetaneous microcirculation. In this paper, we present a model and supporting experiments confirming the contribution of skin inhomogeneity to the morphology of PPG waveforms. The physical-mathematical model of distribution of optical radiation in biological tissues was developed. It allows determining the change of intensity of optical radiation depending on such parameters as installation angle of the sensor, biological tissue thickness and the wavelength. We obtained graphics which represent changes of the optical radiation intensity that is registered by photodetector depending on installation angle of the sensor, biological tissue thickness and the extinction coefficient.
The paper evaluated the diagnostic value of laser photoplethysmography when examining patients with chronic lower limb ischemia. A statistical analysis of the research results was made, and diagrams of relationship between the degrees of ischemia and blood flow are presented. Development of the device to determine the level of peripheral blood circulation and saturation was presented. Also additional accessories in the form of optical fibers for different applications were suggested.
The paper evaluated the diagnostic value of laser photoplethysmography when examining patients with chronic lower limb ischemia. A statistical analysis of the research results was made, and diagrams of relationship between the degrees of ischemia and blood flow are presented.
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