Intense pulsed light (IPL) is an incoherent high intensity pulsed light source and commonly used in dermatology and aesthetics. Early studies suggest that the combination of IPL and photosensitizer can induce cellular phototoxicity. Hemoporfin is a domestic photosensitizer approved for PDT treatment of Portwine stain birthmarks. This in vivo study evaluated the feasibility of using IPL as a light source for the excitation of Hemoporfin in mouse model. Results showed that IPL+Hemoporfin could cause more severe photodamage than IPL alone group, which suggests that it might be feasible to use IPL as PDT light source.
Intense pulsed light (IPL) is an incoherent high-intensity pulsed light and early studies suggest that it might be used in photodynamic therapy (PDT). This study investigated the feasibility of using IPL combined with Hemporfin, a porphyrin-type photosensitizer. The photodynamic effects of two IPL light sources (560-1200 nm and 640-1200 nm) were determined by photobleaching of Hemporfin and Hemporfin-mediated cell killing experiments. Results showed that when combined with Hemoporfin both IPLs could generate photodynamic effects. Therefore, it is feasible to use IPL as PDT light source.
Photosensitizer is a key element of photodynamic therapy (PDT). Currently, only limited numbers of photosensitizers are available for antitumor PDT in China. YLG-1 (Ang-Da-Fen-Qi) is a newly developed second-generation chlorin-type photosensitizer. In this preliminary study, the killing effect of combination of YLG-1 and 652 nm diode laser on human nasopharyngeal carcinoma cells and human ovarian cancer cells were investigated. In vitrostudy suggests that YLG-1 mediated PDT activity has strong cancer cell killing effect and therefore potentials for antitumor PDT applications.
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