Organophosphates (OPs) are a class of pesticides and chemical warfare, several of which are highly toxic. Based on the newest report, there are nearly three million poisonings per year resulting in two hundred thousand deaths around the world. Inspired by the Liquid Crystals (LCs)’ extraordinary properties, we employed a customized LCs sensor to detect OPs with high sensitivity & selectivity, fast response time, and reusability. As proof of our research, four different measurements were operated in the experiments: sensitivity, response time, selectivity, and reusability. The results showed that the limit of detection (LOD) of our proposed sensing method can selectively detect OPs lower to the 10ppb concentration in 25 seconds in four different vapors (OPs, Steam, Ethyl alcohol, and Methylbenzene), which was far lower than the US EPA safety levels for OPs and also faster than the other competitors. Further, the sensor can be recovered by the nitrogen gas treatment in 30 seconds.
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