Pilot study: intra-tumor heterogeneity of lower grade glioma samples using multi-modal optical coherence microscopy

Antonia Lichtenegger; Johanna Gesperger; Barbara Kiesel; Thomas Roetzer; Pablo Eugui; Matthias Salas; Conrad W. Merkle; Georg Widhalm; Adelheid Wöhrer; Bernhard Baumann

doi:10.1117/12.2575071

5 March 2021 Pilot study: intra-tumor heterogeneity of lower grade glioma samples using multi-modal optical coherence microscopy

Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Thomas Roetzer, Pablo Eugui, Matthias Salas, Conrad W. Merkle, Georg Widhalm, Adelheid Wöhrer, Bernhard Baumann

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Proceedings Volume 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV; 116301P (2021) https://doi.org/10.1117/12.2575071
Event: SPIE BiOS, 2021, Online Only

Conference Poster

Abstract

In this pilot study, a multi-modal optical coherence microscopy (OCM) and fluorescence imaging system in the visible wavelength region was utilized to investigate the intra-tumor heterogeneity of lower grade brain tumor samples. OCM intensity data derived attenuation coefficients were calculated and cell density maps were created from intensity en-face projections. Sequentially preoperatively administrated 5-ALA fluorescence intensities were evaluated using the multi-modal setup. Optical imaging data results were compared to histology-derived cell density and cell proliferation rate maps.

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Antonia Lichtenegger, Johanna Gesperger, Barbara Kiesel, Thomas Roetzer, Pablo Eugui, Matthias Salas, Conrad W. Merkle, Georg Widhalm, Adelheid Wöhrer, and Bernhard Baumann "Pilot study: intra-tumor heterogeneity of lower grade glioma samples using multi-modal optical coherence microscopy", Proc. SPIE 11630, Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXV, 116301P (5 March 2021); https://doi.org/10.1117/12.2575071

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