Dr. Jianhua Zhao Profile

Dr. Jianhua Zhao

Research Associate at BC Cancer Research Institute

SPIE Involvement:

Author

Area of Expertise:

Biomedical Optics , Raman & Fluorescence Spectroscopy , Photomedicine , Nonlinear Microscopy, Two-Photon Confocal Microscopy , Optoelectronics , Lasers

Publications (31)

Proceedings Article | 13 March 2024 Presentation

Presentation

Data augmentation strategies for Raman spectral analysis: application for skin cancer discrimination

Jianhua Zhao, Harvey Lui, Sunil Kalia, Tim Lee, Haishan Zeng

Proceedings Volume PC12816, PC128160F (2024) https://doi.org/10.1117/12.3009005

KEYWORDS: Raman spectroscopy, Skin cancer, Machine learning, Lawrencium, Education and training, Cancer detection, Convolutional neural networks, Support vector machines, Statistical analysis, Skin

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Proceedings Article | 13 March 2024 Presentation

Presentation

Fast-speed tilted-plane volumetric imaging of freshly excised human skin tissues

Zhenguo Wu, Tashmeeta Ahad, Sunil Kalia, Harvey Lui, Shujian Li, Jianhua Zhao, Haishan Zeng

Proceedings Volume PC12816, PC128160L (2024) https://doi.org/10.1117/12.3008997

KEYWORDS: Tissues, Skin, Natural surfaces, Scanners, Imaging systems, Confocal microscopy, Tumors, Surgery, Skin cancer, Second harmonic generation

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Proceedings Article | 13 March 2024 Presentation

Presentation

investigation of skin dynamic response after precise multiphoton photothermolysis using noninvasive multimodality microscopy and imaging-guided micro-Raman spectroscopy

Shujian Li, Yunxian Tian, Zhenguo Wu, Jianhua Zhao, Harvey Lui, Sunil Kalia, Haishan Zeng

Proceedings Volume PC12816, PC1281605 (2024) https://doi.org/10.1117/12.3008995

KEYWORDS: Skin, Micro raman spectroscopy, Spectral response, Multiphoton microscopy, Tissues, Multimodal imaging, Imaging systems, Second harmonic generation, Laser therapeutics, In vivo imaging

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Proceedings Article | 13 March 2024 Presentation

Presentation

Development of a mini-phototest method for precision phototherapy

Giselle Tian, Zhenguo Wu, Jianhua Zhao, Harvey Lui, Sunil Kalia, Haishan Zeng

Proceedings Volume PC12816, PC128160D (2024) https://doi.org/10.1117/12.3009063

KEYWORDS: Phototherapy, Skin, Ultraviolet radiation, Multiphoton microscopy, Monte Carlo methods, Confocal microscopy, Tissues, Reflectivity, Modeling, In vivo imaging

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Proceedings Article | 17 March 2023 Presentation

Presentation

Using spectroscopy to study skin conditions

Sunil Kalia, Haishan Zeng, Tashmeeta Ahad, Jianhua Zhao, Harvey Lui

Proceedings Volume PC12352, PC123520A (2023) https://doi.org/10.1117/12.2657459

KEYWORDS: Skin, Raman spectroscopy, Spectroscopy, Proteins, Tissue optics, Spectrographs, Semiconductor lasers, Optical inspection, Neck, Molecular spectroscopy

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Proceedings Article | 17 March 2023 Presentation

Presentation

In vivo human skin dermal–epidermal junction zone delineation by volumetric multiphoton microscopy imaging

Giselle Tian, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Sunil Kalia, Haishan Zeng

Proceedings Volume PC12352, PC123520P (2023) https://doi.org/10.1117/12.2657147

KEYWORDS: Skin, Multiphoton microscopy, In vivo imaging, 3D image processing, Image segmentation, Algorithm development, Visualization, Stereoscopy, Microscopy

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Proceedings Article | 17 March 2023 Presentation

Presentation

In vivo micro-Raman spectroscopy of arbitrary-shaped region of interest under simultaneous reflectance confocal imaging guidance

Zhenguo Wu, Liwei Jiang, Jianhua Zhao, Haishan Zeng

Proceedings Volume PC12352, PC1235208 (2023) https://doi.org/10.1117/12.2657150

KEYWORDS: Raman spectroscopy, In vivo imaging, Confocal microscopy, Reflectivity, Micro raman spectroscopy, Imaging systems, Chromium, Visualization, Tissue optics, Target acquisition

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Proceedings Article | 7 March 2022 Presentation

Presentation

Precise monitoring of skin cellular changes in vivo at the same micro-location over a long period of weeks using MPM based multimodality microscopy

Yunxian (Giselle) Tian, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Sunil Kalia, Haishan Zeng

Proceedings Volume PC11934, PC1193406 (2022) https://doi.org/10.1117/12.2615707

KEYWORDS: Skin, Microscopy, In vivo imaging, Imaging systems, Two photon imaging, Confocal microscopy, Tissues, Tissue optics, Solar radiation, Signal analyzers

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Proceedings Article | 6 March 2020 Presentation

Presentation

Precise closure of single blood vessels via multiphoton photothermolysis (Conference Presentation)

Yimei Huang, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Shusen Xie, Haishan Zeng

Proceedings Volume 11211, 112110J (2020) https://doi.org/10.1117/12.2550983

KEYWORDS: Blood vessels, Laser tissue interaction, Absorption, In vivo imaging, Reflectivity, Confocal microscopy, Laser therapeutics, Laser energy, Chromophores, Near infrared

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Proceedings Article | 4 March 2019 Presentation

Presentation

Tracking cellular dynamics of human skin responses to UV exposure using in vivo multimodal microscopy (Conference Presentation)

Giselle Tian, Harvey Lui, Jianhua Zhao, Zhenguo Wu, Sunil Kalia, Vincent Richer, InSeok Seo, Hao Ouyang, Haishan Zeng

Proceedings Volume 10851, 108510S (2019) https://doi.org/10.1117/12.2513734

KEYWORDS: Skin, In vivo imaging, Microscopy, Ultraviolet radiation, Imaging systems, Confocal microscopy, Two photon imaging, Solar radiation, Biopsy, Biological research

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Proceedings Article | 4 March 2019 Presentation

Presentation

In vivo tissue micro-Raman spectroscopy with simultaneous reflectance confocal microscopy monitoring using a single laser (Conference Presentation)

Zhenguo Wu, Liwei Jiang, Wenbo Wang, Jianhua Zhao, Harvey Lui, Haishan Zeng

Proceedings Volume 10851, 108510U (2019) https://doi.org/10.1117/12.2513719

KEYWORDS: Confocal microscopy, Raman spectroscopy, In vivo imaging, Reflectivity, Chromium, Beam splitters, Laser tissue interaction, Micro raman spectroscopy, Imaging systems, Tissue optics

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Proceedings Article | 4 March 2019 Presentation

Presentation

Incorporating demographics into a skin cancer diagnosis algorithm for Raman spectroscopy improves diagnostic specificity (Conference Presentation)

Jianhua Zhao, Haishan Zeng, Sunil Kalia, Harvey Lui

Proceedings Volume 10851, 1085102 (2019) https://doi.org/10.1117/12.2513779

KEYWORDS: Skin cancer, Raman spectroscopy, Skin, Diagnostics, Statistical analysis, Tissue optics, In vivo imaging, Spectroscopy, Melanoma, Cancer

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Proceedings Article | 18 January 2018 Paper

Paper

Applications of polarization speckle in skin cancer detection and monitoring

Tim Lee, Lioudmila Tchvialeva, Jamie Phillips, Daniel Louie, Jianhua Zhao, Wei Wang, Harvey Lui, Sunil Kalia

Proceedings Volume 10612, 106121B (2018) https://doi.org/10.1117/12.2305383

KEYWORDS: Polarization, Speckle, Skin, Skin cancer, Cancer, Diffuse reflectance spectroscopy, Melanoma, Reflectivity, Speckle pattern, Scattering

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Proceedings Article | 19 April 2017 Presentation

Presentation

Wavenumber selection based analysis in Raman spectroscopy improves skin cancer diagnostic specificity at high sensitivity levels (Conference Presentation)

Jianhua Zhao, Haishan Zeng, Sunil Kalia, Harvey Lui

Proceedings Volume 10037, 1003708 (2017) https://doi.org/10.1117/12.2256375

KEYWORDS: Raman spectroscopy, Diagnostics, Skin cancer, Tissue optics, Skin, Statistical analysis, Molecular spectroscopy, Time metrology, Receivers, Analytical research

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Proceedings Article | 27 April 2016 Presentation

Presentation

Cutaneous porphyrins exhibit anti-stokes fluorescence that is detectable in sebum (Conference Presentation)

Giselle Tian, Haishan Zeng, Jianhua Zhao, Zhenguo Wu, Mohammed Al Jasser, Harvey Lui, David Mclean

Proceedings Volume 9689, 968910 (2016) https://doi.org/10.1117/12.2217210

KEYWORDS: Luminescence, Near infrared, Skin, Fluorescence spectroscopy, Visible radiation, Continuous wave operation, Multiphoton fluorescence microscopy, Lamps, Ultraviolet radiation, Target detection

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Proceedings Article | 27 April 2016 Presentation

Presentation

Fluorescence excitation-emission matrix spectroscopy of vitiligo skin in vivo (Conference Presentation)

Jianhua Zhao, Vincent Richer, Mohammed Al Jasser, Soodabeh Zandi, Nikiforos Kollias, Sunil Kalia, Haishan Zeng, Harvey Lui

Proceedings Volume 9689, 968911 (2016) https://doi.org/10.1117/12.2214210

KEYWORDS: Luminescence, Skin, Fluorescence spectroscopy, Spectroscopy, In vivo imaging, Absorption, Tissue optics, Molecules, Photons, Inflammation

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Proceedings Article | 27 April 2016 Presentation

Presentation

In vivo multimodality video microscopy of human skin in the vertical plane (Conference Presentation)

Zhenguo Wu, Yunxian Tian, Jianhua Zhao, Harvey Lui, David McLean, Haishan Zeng

Proceedings Volume 9689, 96890Y (2016) https://doi.org/10.1117/12.2212091

KEYWORDS: Skin, In vivo imaging, Video microscopy, Video, Cancer, Skin cancer, Reflectivity, Confocal microscopy, Multiphoton microscopy, Natural surfaces

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Proceedings Article | 27 April 2016 Presentation

Presentation

Monitoring femtosecond laser microscopic photothermolysis with multimodal microscopy (Conference Presentation)

Yimei Huang, Harvey Lui, Jianhua Zhao, David McLean, Haishan Zeng

Proceedings Volume 9689, 96890P (2016) https://doi.org/10.1117/12.2214798

KEYWORDS: Femtosecond phenomena, Microscopy, Second-harmonic generation, Skin, Absorption, Confocal microscopy, Cancer, Dermatology, Near infrared, Reflectivity

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SPIE Journal Paper | 17 June 2014 Open Access

Open Access

Clinical Raman measurements under special ambient lighting illumination

Jianhua Zhao, Michael Short, Thomas Braun, Harvey Lui, David McLean, Haishan Zeng

JBO, Vol. 19, Issue 11, 111609, (June 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.11.111609

KEYWORDS: Raman spectroscopy, Light emitting diodes, Lamps, Bandpass filters, Optical filters, Near infrared, Skin, Light sources and illumination, Light sources, Biomedical optics

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Proceedings Article | 28 February 2014 Paper

Paper

Investigating backward scattered second harmonic generation from various mouse collagen tissues

Mengzhe Shen, Yunxian Tian, Shau Poh Chong, Jianhua Zhao, Haishan Zeng, Shuo Tang

Proceedings Volume 8948, 89482V (2014) https://doi.org/10.1117/12.2041170

KEYWORDS: Second-harmonic generation, Tissues, Skin, Scattering, Collagen, Harmonic generation, Multiphoton microscopy, Confocal microscopy, Photons, Imaging systems

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SPIE Journal Paper | 5 November 2013 Open Access

Open Access

Quantifying the backscattering of second harmonic generation in tissues with confocal multiphoton microscopy

Mengzhe Shen, Yunxian Tian, Shau Poh Chong, Jianhua Zhao, Haishan Zeng, Shuo Tang

JBO, Vol. 18, Issue 11, 115003, (November 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.11.115003

KEYWORDS: Second-harmonic generation, Tissues, Scattering, Harmonic generation, Optical fibers, Backscatter, Confocal microscopy, Tissue optics, Multiphoton microscopy, Monte Carlo methods

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SPIE Journal Paper | 8 February 2013 Open Access

Open Access

Calibrating the measurement of wavelength-dependent second harmonic generation from biological tissues with a BaB2O4 crystal

Mengzhe Shen, Jianhua Zhao, Haishan Zeng, Shuo Tang

JBO, Vol. 18, Issue 03, 031109, (February 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.3.031109

KEYWORDS: Second-harmonic generation, Calibration, Tissues, Crystals, Polarization, Harmonic generation, Objectives, Collagen, Collimation, Phase matching

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SPIE Journal Paper | 6 July 2012 Open Access

Open Access

Imaging-guided two-photon excitation-emission-matrix measurements of human skin tissues

Yingqiu Yu, Anthony Lee, Hequn Wang, Jianhua Zhao, Harvey Lui, Haishan Zeng, Shuo Tang

JBO, Vol. 17, Issue 7, 077004, (July 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.7.077004

KEYWORDS: Skin, Tissues, Collagen, Second-harmonic generation, Imaging spectroscopy, Imaging systems, Optical fibers, Spectroscopy, Luminescence, Calibration

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Proceedings Article | 9 February 2012 Paper

Paper

A study on the spectral dependence of second harmonic generation from collagen tissues

Mengzhe Shen, Hequn Wang, Anthony Lee, Jianhua Zhao, Haishan Zeng, Shuo Tang

Proceedings Volume 8226, 82263R (2012) https://doi.org/10.1117/12.909646

KEYWORDS: Second-harmonic generation, Collagen, Photons, Tissues, Scattering, Rayleigh scattering, Mie scattering, Calibration, Skin, Light scattering

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Proceedings Article | 18 February 2011 Paper

Paper

Assessing topographic cutaneous autofluorescence variation using fluorescence UV and visible excitation emission matrix (EEM) spectroscopy

Jianhua Zhao, Soodabeh Zandi, Florina Feng, Haishan Zeng, David McLean, Harvey Lui

Proceedings Volume 7883, 78830I (2011) https://doi.org/10.1117/12.878770

KEYWORDS: Luminescence, Skin, Spectroscopy, Calibration, Lamps, Fluorescence spectroscopy, Mirrors, Emission spectroscopy, Sensors, Collagen

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Proceedings Article | 24 March 2010 Paper

Paper

New multimodal multiphoton imaging and spectroscopy apparatus for dermatology

Yingqiu Yu, Anthony Lee, Hequn Wang, Jianhua Zhao, Shuo Tang, Harvey Lui, David McLean, Haishan Zeng

Proceedings Volume 7548, 75480N (2010) https://doi.org/10.1117/12.847112

KEYWORDS: Imaging spectroscopy, Confocal microscopy, Skin cancer, Spectroscopes, Luminescence, Second-harmonic generation, Multiphoton spectroscopy, Dermatology, Skin, In vivo imaging

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Proceedings Article | 5 March 2010 Paper

Paper

Carbon nanotube assisted photothermal therapy of skin cancers: pilot proof-of-principle study in a murine model

Naiyan Huang, Hequn Wang, Jianhua Zhao, Harvey Lui, Mladen Korbelik, Haishan Zeng

Proceedings Volume 7548, 75480H (2010) https://doi.org/10.1117/12.848279

KEYWORDS: Tumors, Single walled carbon nanotubes, Raman spectroscopy, Carbon nanotubes, Tumor growth modeling, Laser irradiation, Nanomaterials, Skin cancer, Cancer, Tissue optics

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Proceedings Article | 19 February 2009 Paper

Paper

In vivo confocal Raman spectroscopy for skin disease diagnosis and characterization: preliminary results from mouse tumor models

Hequn Wang, Naiyan Huang, Jianhua Zhao, Harvey Lui, Mladen Korbelik, Haishan Zeng

Proceedings Volume 7161, 716108 (2009) https://doi.org/10.1117/12.810953

KEYWORDS: Skin, Raman spectroscopy, Tumors, Confocal microscopy, In vivo imaging, Tissue optics, Skin cancer, Chemical analysis, Spectroscopy, Collagen

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Proceedings Article | 8 February 2008 Paper

Paper

Quantitative analysis of skin chemicals using rapid near-infrared Raman spectroscopy

Jianhua Zhao, Zhiwei Huang, Haishan Zeng, David McLean, Harvey Lui

Proceedings Volume 6842, 684209 (2008) https://doi.org/10.1117/12.769373

KEYWORDS: Raman spectroscopy, Skin, Quantitative analysis, Molecules, Luminescence, Chemical analysis, Cancer, Spectrographs, Skin cancer, Tissues

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Proceedings Article | 8 February 2008 Paper

Paper

Development and preliminary results of an in vivo Raman probe for early lung cancer detection

Michael Short, Stephen Lam, Annette McWilliams, Jianhua Zhao, Harvey Lui, Haishan Zeng

Proceedings Volume 6853, 68530J (2008) https://doi.org/10.1117/12.764034

KEYWORDS: Raman spectroscopy, Lung cancer, In vivo imaging, Tissue optics, Spectroscopy, Lung, Optical filters, Charge-coupled devices, Cancer, Tissues

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Proceedings Article | 22 February 2006 Paper

Paper

Multimode spectroscopy for the in vivo assessment of post-inflammatory pigmentation: preliminary observations

Jianhua Zhao, Hana Alkhayat, Ahmad Al Robaee, Haishan Zeng, David McLean, Harvey Lui

Proceedings Volume 6078, 607809 (2006) https://doi.org/10.1117/12.650200

KEYWORDS: Skin, Raman spectroscopy, Diffuse reflectance spectroscopy, Spectroscopy, Reflectivity, In vivo imaging, Luminescence, Near infrared, Fluorescence spectroscopy, Skin cancer

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Showing 5 of 31 publications

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