Prof. Lorenzo Spinelli Profile

Prof. Lorenzo Spinelli

Researcher at CNR-Istituto di Fotonica e Nanotecnologie

SPIE Involvement:

Author

Publications (109)

SPIE Journal Paper | 14 October 2023 Open Access

Open Access

Cerebrovascular reactivity to carbon dioxide tension in newborns: data from combined time-resolved near-infrared spectroscopy and diffuse correlation spectroscopy

Sofia Passera, Agnese De Carli, Monica Fumagalli, Davide Contini, Nicola Pesenti, Caterina Amendola, Martina Giovannella, Turgut Durduran, Udo Weigel, Lorenzo Spinelli, Alessandro Torricelli, Gorm Greisen

NPh, Vol. 10, Issue 04, 045003, (October 2023) https://doi.org/10.1117/12.10.1117/1.NPh.10.4.045003

KEYWORDS: Oxygen, Near infrared spectroscopy, Tissues, Brain, Blood circulation, Neurophotonics, Time resolved spectroscopy, Oxygenation, Statistical analysis, Sensors

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Proceedings Article | 9 August 2023 Paper

Paper

Assessing TD fNIRS capability to detect hemodynamic oscillations in cerebral cortex

L. Contini, R. Re, D. Contini, A. Torricelli, L. Spinelli

Proceedings Volume 12628, 126280H (2023) https://doi.org/10.1117/12.2670919

KEYWORDS: Hemodynamics, Cerebral cortex, Tissues, Signal detection, Near infrared spectroscopy, In vivo imaging, Feature extraction, Diffusion

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Proceedings Article | 9 August 2023 Paper

Paper

Evaluation of muscle aging with TD NIRS and DCS

M. Nabacino, C. Amendola, D. Contini, L. Spinelli, A. Torricelli, A. Pilotto, M. Ansaldo, S. Porcelli, F. Lauretani, A. Hoxha, M. Maggio, R. Re

Proceedings Volume 12628, 126282E (2023) https://doi.org/10.1117/12.2670876

KEYWORDS: Muscles, Near infrared spectroscopy, Hemodynamics, Blood circulation, Oxygen, Tissues, Spectroscopy, Medicine, Electromyography

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Proceedings Article | 9 August 2023 Paper

Paper

Effects of red blood cell transfusion on neonatal cerebral hemodynamics: a TD-NIRS and DCS study

C. Amendola, T. Boggini, C. Martinelli, D. Contini, L. Spinelli, A. De Carli, F. Mosca, U. Weigel, T. Durduran, B. Andresen, A. Torricelli, G. Greisen, M. Fumagalli

Proceedings Volume 12628, 126280M (2023) https://doi.org/10.1117/12.2670585

KEYWORDS: Red blood cells, Oxygen, Hemodynamics, Tissues, Blood circulation, Spectroscopes, Risk assessment, Oxygenation, Optical components, Near infrared spectroscopy

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Proceedings Article | 9 August 2023 Paper

Paper

Cerebral resting state oscillations study with TD fNIRS

R. Re, L. Contini, D. Contini, F. Orihuela-Espina, A. Torricelli, L. Spinelli

Proceedings Volume 12628, 126280I (2023) https://doi.org/10.1117/12.2668895

KEYWORDS: Temperature metrology, Spectral density, Skin, Sampling rates, Pulse signals, Numerical simulations, Near infrared spectroscopy, In vivo imaging, Hemodynamics, Brain

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Proceedings Article | 9 August 2023 Paper

Paper

Cerebral hemodynamics monitoring during extracorporeal membrane oxygenation in piglets

C. Amendola, G. Cavallaro, G. Amelio, L. Provitera, G. Raffaeli, F. Mosca, L. Spinelli, A. Torricelli, D. Contini

Proceedings Volume 12628, 126280F (2023) https://doi.org/10.1117/12.2670871

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Oxygenation, Tissues, Spectroscopes, Oxygen, Continuous wave operation, Cerebral blood flow

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SPIE Journal Paper | 17 July 2023 Open Access

Open Access

Robustness of tissue oxygenation estimates by continuous wave space-resolved near infrared spectroscopy

Caterina Amendola, Davide Contini, Rebecca Re, Lorenzo Spinelli, Lorenzo Frabasile, Pietro Levoni, Alessandro Torricelli

JBO, Vol. 28, Issue 07, 075002, (July 2023) https://doi.org/10.1117/12.10.1117/1.JBO.28.7.075002

KEYWORDS: Tissues, Hemodynamics, Scattering, Near infrared spectroscopy, Oxygenation, Error analysis, Simulations, Muscles, Adaptive optics, Oxygen

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SignificanceContinuous wave near infrared spectroscopy (CW-NIRS) is widely exploited in clinics to estimate skeletal muscles and brain cortex oxygenation. Spatially resolved spectroscopy (SRS) is generally implemented in commercial devices. However, SRS suffers from two main limitations: the a priori assumption on the spectral dependence of the reduced scattering coefficient [μs′(λ)] and the modeling of tissue as homogeneous.AimWe studied the accuracy and robustness of SRS NIRS. We investigated the errors in retrieving hemodynamic parameters, in particular tissue oxygen saturation (StO2), when μs′(λ) was varied from expected values, and when layered tissue was considered.ApproachWe simulated hemodynamic variations mimicking real-life scenarios for skeletal muscles. Simulations were performed by exploiting the analytical solutions of the photon diffusion equation in different geometries: (1) semi-infinite homogeneous medium and constant μs′(λ); (2) semi-infinite homogeneous medium and linear changes in μs′(λ); (3) two-layered media with a superficial thickness s1 = 5, 7.5, 10 mm and constant μs′(λ). All simulated data were obtained at source-detector distances ρ = 35, 40, 45 mm, and analyzed with the SRS approach to derive hemodynamic parameters (concentration of oxygenated and deoxygenated hemoglobin, total hemoglobin concentration, and tissue oxygen saturation, StO2) and their relative error.ResultsVariations in μs′(λ) affect the estimated StO2 (up to ±10 % ), especially if changes are different at the two wavelengths. However, the main limitation of the SRS method is the presence of a superficial layer: errors strongly larger than 20% were retrieved for the estimated StO2 when the superficial thickness exceeds 5 mm.ConclusionsThese results highlight the need for more sophisticated strategies (e.g., the use of multiple short and long distances) to reduce the influence of superficial tissues in retrieving hemodynamic parameters and warn the SRS users to be aware of the intrinsic limitation of this approach, particularly when exploited in the clinical environment.

SPIE Journal Paper | 30 August 2022 Open Access

Open Access

Optical imaging and spectroscopy for the study of the human brain: status report

Hasan Ayaz, Wesley Baker, Giles Blaney, David Boas, Heather Bortfeld, Kenneth Brady, Joshua Brake, Sabrina Brigadoi, Erin M. Buckley, Stefan Carp, Robert Cooper, Kyle Cowdrick, Joseph Culver, Ippeita Dan, Hamid Dehghani, Anna Devor, Turgut Durduran, Adam Eggebrecht, Lauren Emberson, Qianqian Fang, Sergio Fantini, Maria Angela Franceschini, Jonas Fischer, Judit Gervain, Joy Hirsch, Keum-Shik Hong, Roarke Horstmeyer, Jana Kainerstorfer, Tiffany Ko, Daniel Licht, Adam Liebert, Robert Luke, Jennifer Lynch, Jaume Mesquida, Rickson Mesquita, Noman Naseer, Sergio Novi, Felipe Orihuela-Espina, Thomas O'Sullivan, Darcy Peterka, Antonio Pifferi, Luca Pollonini, Angelo Sassaroli, João Ricardo Sato, Felix Scholkmann, Lorenzo Spinelli, Vivek Srinivasan, Keith St. Lawrence, Ilias Tachtsidis, Yunjie Tong, Alessandro Torricelli, Tara Urner, Heidrun Wabnitz, Martin Wolf, Ursula Wolf, Shiqi Xu, Changhuei Yang, Arjun Yodh, Meryem Yücel, Wenjun Zhou

NPh, Vol. 9, Issue S2, S24001, (August 2022) https://doi.org/10.1117/12.10.1117/1.NPh.9.S2.S24001

KEYWORDS: Brain, Near infrared spectroscopy, Neuroimaging, Imaging spectroscopy, Sensors, Optical imaging, Optical spectroscopy imaging, Optical spectroscopy, Spectroscopy, Tissue optics

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SPIE Journal Paper | 15 June 2022 Open Access

Open Access

Multi-laboratory performance assessment of diffuse optics instruments: the BitMap exercise

Pranav Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Michał Kacprzak, Piotr Sawosz, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu-Venkata-Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Lorenzo Frabasile, Pietro Levoni, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Paola Taroni, Alberto Tosi, Alessandro Torricelli, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

JBO, Vol. 27, Issue 07, 074716, (June 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.074716

KEYWORDS: Raster graphics, Optical properties, Diffuse optical imaging, Scattering, Imaging spectroscopy, Absorption, Tissue optics, Spectroscopes, Sensors, Oximetry

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SPIE Journal Paper | 2 February 2022 Open Access

Open Access

Reproducibility of identical solid phantoms

Fangzhou Zhao, Pietro Levoni, Lorenzo Frabasile, Hong Qi, Michele Lacerenza, Pranav Lanka, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu, Lorenzo Spinelli

JBO, Vol. 27, Issue 07, 074713, (February 2022) https://doi.org/10.1117/12.10.1117/1.JBO.27.7.074713

KEYWORDS: Scattering, Silicon, Absorption, Solids, Optical properties, Picosecond phenomena, Near infrared spectroscopy, Epoxies, Diffuse optical imaging, Visible radiation

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Proceedings Article | 9 December 2021 Paper

Paper

Discrimination between healthy and glaucomatous subjects with TD-fNIRS

R. Re, D. Messenio, G. Marano, L. Spinelli, I. Pirovano, D. Contini, R. Colombo, P. Boracchi, E. Biganzoli, R. Cubeddu, A. Torricelli

Proceedings Volume 11920, 119200G (2021) https://doi.org/10.1117/12.2615222

KEYWORDS: Visualization, Eye, Statistical analysis, Brain, Hemodynamics, Eye models, Absorption, Visual optics, Scattering, Medical devices

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Proceedings Article | 9 December 2021 Paper

Paper

Filament 3D printing technology for diffuse optics applications: advantages and drawbacks

Caterina Amendola, Michele Lacerenza, Ileana Pirovano, Davide Contini, Lorenzo Spinelli, Rinaldo Cubeddu, Alessandro Torricelli, Rebecca Re

Proceedings Volume 11920, 1192020 (2021) https://doi.org/10.1117/12.2615431

KEYWORDS: 3D printing, Mass attenuation coefficient, Printing, 3D metrology, Near infrared spectroscopy, Diffuse optical imaging, 3D acquisition, Spectroscopy, Photons, Optical properties

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Proceedings Article | 9 December 2021 Paper

Paper

Sensitivity of TD-NIRS in estimating neonatal cerebral hemodynamics with homogenous models of analysis

Caterina Amendola, Lorenzo Spinelli, Davide Contini, Agnese De Carli, Cesare Martinelli, Monica Fumagalli, Alessandro Torricelli

Proceedings Volume 11920, 1192011 (2021) https://doi.org/10.1117/12.2615338

KEYWORDS: Brain, Head, Monte Carlo methods, Hemodynamics, Near infrared spectroscopy, Spherical lenses, Tissues, Optical properties, Photon transport, Absorption

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Proceedings Article | 9 December 2021 Paper

Paper

Brain activations during programming tasks: TD-NIRS and EEG study

Caterina Amendola, Alessandra Calcagno, Rebecca Re, Ileana Pirovano, Davide Contini, Lorenzo Spinelli, Ricardo Couceiro, João Durães, Raul Barbosa, Paulo de Carvalho, Henrique Madeira, Anna Maria Bianchi, Alessandro Torricelli

Proceedings Volume 11920, 119200K (2021) https://doi.org/10.1117/12.2615229

KEYWORDS: Electroencephalography, Computer programming, Hemodynamics, Brain activation, Sensors, Near infrared spectroscopy, Brain, Statistical analysis, Computer programming languages, Visualization

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Proceedings Article | 9 December 2021 Paper

Paper

Adipose tissue thickness and optical properties affect differential pathlength factor in NIRS studies on human skeletal muscle

Ileana Pirovano, Simone Porcelli, Rebecca Re, Lorenzo Spinelli, Davide Contini, Mauro Marzorati, Alessandro Torricelli

Proceedings Volume 11920, 119200T (2021) https://doi.org/10.1117/12.2615254

KEYWORDS: Near infrared spectroscopy, Tissue optics, Optical properties, In vivo imaging, Scattering, Tissues, Absorption, Photons, Time metrology, Spectroscopy

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Proceedings Article | 9 December 2021 Paper

Paper

A hybrid DCS and TD-NIRS device for monitoring tissue oxygenation and perfusion, towards ICU applications

Caterina Amendola, Michele Lacerenza, Mauro Buttafava, Marta Zanoletti, Lorenzo Cortese, Marco Pagliazzi, Alberto Tosi, Lorenzo Spinelli, Turgut Durduran, Alessandro Torricelli, Davide Contini

Proceedings Volume 11920, 1192007 (2021) https://doi.org/10.1117/12.2615207

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Tissues, In vivo imaging, Blood circulation, Tissue optics, Spectroscopes, Skin, Dubnium, Time metrology

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Proceedings Article | 9 December 2021 Paper

Paper

Motor cortex hemodynamic response function in freely moving subjects recorded via time domain fNIRS

Michele Lacerenza, Mauro Buttafava, Lorenzo Spinelli, Alberto Tosi, Alberto Dalla Mora, Franco Zappa, Antonio Pifferi, Bruno Cozzi, Alessandro Torricelli, Davide Contini

Proceedings Volume 11920, 1192018 (2021) https://doi.org/10.1117/12.2615350

KEYWORDS: Hemodynamics, Human subjects, Brain activation, Brain, Tissue optics, Solids, Scattering, Near infrared spectroscopy, Laser scattering, Functional magnetic resonance imaging

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Proceedings Article | 7 December 2021 Paper

Paper

Rehabilitation monitoring after bed rest in elderly: TD-NIRS and sEMG preliminary study

I. Pirovano, A. Laurini, A. Tomba, A. Scano, R. Re, A. Caserta, L. Spinelli, D. Contini, R. Cubeddu, L. Panella, A. Torricelli

Proceedings Volume 11919, 1191921 (2021) https://doi.org/10.1117/12.2615017

KEYWORDS: Tissues, Electromyography, Hemodynamics, Near infrared spectroscopy, Ultrasonography, Surgery, Scattering, Oxygen, Head, Data analysis

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Proceedings Article | 7 December 2021 Paper

Paper

Assessment of muscular sustained fatigue: a TD-NIRS and sEMG study

R. Re, A. Scano, I. Pirovano, M. Manunza, L. Spinelli, D. Contini, A. Torricelli

Proceedings Volume 11919, 119191H (2021) https://doi.org/10.1117/12.2614859

KEYWORDS: Near infrared spectroscopy, Signal detection, Mode conditioning cables, Tissue optics, Reflectivity, Physics, Oxygen, Optical testing, Motion analysis, Medical device development

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Proceedings Article | 5 March 2021 Presentation + Paper

Presentation + Paper

“Walking” into freely moving brain monitoring via real-time TD-NIRS

Michele Lacerenza, Mauro Buttafava, Lorenzo Spinelli, Alberto Tosi, Alberto Dalla Mora, Antonio Pifferi, Bruno Cozzi, Alessandro Torricelli, Franco Zappa, Davide Contini

Proceedings Volume 11639, 116390V (2021) https://doi.org/10.1117/12.2578196

KEYWORDS: Brain, Oximetry, Pathology, Tissue optics, Tissues, Standards development, Semiconductor lasers, Oximeters, Near infrared spectroscopy, Medicine

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Proceedings Article | 5 March 2021 Presentation + Paper

Presentation + Paper

A multi-laboratory comparison of photon migration instruments and their performances: the BitMap exercise

Sri Rama Pranav Kumar Lanka, Lin Yang, David Orive-Miguel, Joshua Deepak Veesa, Susanna Tagliabue, Aleh Sudakou, Saeed Samaei, Mario Forcione, Zuzana Kovacsova, Anurag Behera, Thomas Gladytz, Dirk Grosenick, Lionel Hervé, Giuseppe Lo Presti, Lorenzo Cortese, Turgut Durduran, Karolina Bejm, Magdalena Morawiec, Piotr Sawosz, Michal Kacprzak, Anna Gerega, Adam Liebert, Antonio Belli, Ilias Tachtsidis, Frédéric Lange, Gemma Bale, Luca Baratelli, Sylvain Gioux, Alexander Kalyanov, Martin Wolf, Sanathana Konugolu Venkata Sekar, Marta Zanoletti, Ileana Pirovano, Michele Lacerenza, Lina Qiu, Edoardo Ferocino, Giulia Maffeis, Caterina Amendola, Lorenzo Colombo, Mauro Buttafava, Marco Renna, Laura Di Sieno, Rebecca Re, Andrea Farina, Lorenzo Spinelli, Alberto Dalla Mora, Davide Contini, Alessandro Torricelli, Alberto Tosi, Paola Taroni, Hamid Dehghani, Heidrun Wabnitz, Antonio Pifferi

Proceedings Volume 11639, 116390F (2021) https://doi.org/10.1117/12.2578521

KEYWORDS: Raster graphics, Photonic devices, Tissue optics, Spectroscopes, Oximetry, Optical components, Mammography, Imaging spectroscopy, Functional imaging

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Proceedings Article | 5 March 2021 Presentation + Paper

Presentation + Paper

Depth selectivity in time-domain fNIRS by analyzing moments and time windows

Aleh Sudakou, Heidrun Wabnitz, Lin Yang, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Adam Liebert

Proceedings Volume 11639, 116390Q (2021) https://doi.org/10.1117/12.2578518

KEYWORDS: Photons, Absorption, Time metrology, Near infrared spectroscopy, Interference (communication), Brain

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SPIE Journal Paper | 22 February 2021 Open Access

Open Access

Monitoring the motor cortex hemodynamic response function in freely moving walking subjects: a time-domain fNIRS pilot study

Michele Lacerenza, Lorenzo Spinelli, Mauro Buttafava, Alberto Dalla Mora, Franco Zappa, Antonio Pifferi, Alberto Tosi, Bruno Cozzi, Alessandro Torricelli, Davide Contini

NPh, Vol. 8, Issue 01, 015006, (February 2021) https://doi.org/10.1117/12.10.1117/1.NPh.8.1.015006

KEYWORDS: Hemodynamics, Brain, Neurophotonics, Near infrared spectroscopy, Tissues, Functional magnetic resonance imaging, Photons, Electroencephalography, Amplifiers, Absorption

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SPIE Journal Paper | 12 July 2019 Open Access

Open Access

Effects of the instrument response function and the gate width in time-domain diffuse correlation spectroscopy: model and validations

Lorenzo Colombo, Marco Pagliazzi, Sanathana Konugolu Venkata Sekar, Davide Contini, Alberto Dalla Mora, Lorenzo Spinelli, Alessandro Torricelli, Turgut Durduran, Antonio Pifferi

NPh, Vol. 6, Issue 03, 035001, (July 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.3.035001

KEYWORDS: Photons, Sensors, Instrument modeling, Scattering, Optical properties, Picosecond phenomena, Diffusion, Spectroscopes, Absorption, Neurophotonics

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Proceedings Article | 11 July 2019 Paper

Paper

In vivo time-domain diffuse correlation spectroscopy of the human muscle above 1000 nm

L. Colombo, M. Pagliazzi, S. Konugolu Venkata Sekar, D. Contini, A. Dalla Mora, L. Spinelli, A. Torricelli, T. Durduran, A. Pifferi

Proceedings Volume 11074, 110742V (2019) https://doi.org/10.1117/12.2527065

KEYWORDS: In vivo imaging, Signal to noise ratio, Spectroscopy, Blood circulation, Laser sources, Absorption, Tissue optics, Scattering, Indium gallium arsenide, Photomultipliers

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Proceedings Article | 11 July 2019 Paper

Paper

Time-resolved near infrared spectroscopy in ischemic stroke patients

Marta Zanoletti, Giacomo Giacalone, Davide Contini, Rebecca Re, Lorenzo Spinelli, Bruno Germinario, Luisa Roveri, Alessandro Torricelli

Proceedings Volume 11074, 110740T (2019) https://doi.org/10.1117/12.2530627

KEYWORDS: Ischemic stroke, Near infrared spectroscopy, Absorption, Scattering, Tissues, Control systems, Brain, Photons, Reflectivity, Mie scattering

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Proceedings Article | 11 July 2019 Paper

Paper

Preliminary vastus lateralis characterization with time domain near infrared spectroscopy during incremental cycle exercise

I. Pirovano, S. Porcelli, F. Azzarello, R. Re, L. Spinelli, D. Contini, M. Marzorati, A. Torricelli

Proceedings Volume 11074, 1107424 (2019) https://doi.org/10.1117/12.2527068

KEYWORDS: Near infrared spectroscopy, Blood, Absorption, Scattering, Tissues, Optical properties, Hemodynamics, Signal processing, Functional near infrared spectroscopy

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Proceedings Article | 11 July 2019 Paper

Paper

Instrument response function acquisition in reflectance geometry for time-resolved diffuse optical measurements

Ileana Pirovano, Rebecca Re, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli

Proceedings Volume 11074, 110742R (2019) https://doi.org/10.1117/12.2526931

KEYWORDS: Reflectivity, Optical fibers, Tissues, Photons, Optical testing, 3D acquisition, Scattering, In vivo imaging, 3D metrology, Data modeling

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Proceedings Article | 11 July 2019 Paper

Paper

Blood-lipid liquid phantom for assessing time and frequency domain tissue oximeter performances

Lorenzo Spinelli, Davide Contini, Antonio Pifferi, Alessandro Torricelli, Udo Weigel, Helene Isler, Daniel Ostojic, Heidrun Wabnitz, Martin Wolf

Proceedings Volume 11074, 110741E (2019) https://doi.org/10.1117/12.2526984

KEYWORDS: Oximeters, Near infrared spectroscopy, Absorption, Tissue optics, Hemodynamics, Visible radiation, Oxygen, Blood

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Proceedings Article | 11 July 2019 Paper

Paper

TD-fNIRS for diagnosing glaucoma: a clinical pilot study

R. Re, D. Messenio, L. Spinelli, I. Pirovano, D. Contini, R. Colombo, R. Cubeddu, A. Torricelli

Proceedings Volume 11074, 110741K (2019) https://doi.org/10.1117/12.2526961

KEYWORDS: Visualization, Visual cortex, Hemodynamics, Signal detection, Eye, Optic nerve, Brain, Optical coherence tomography, Visual optics, Optical discs

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SPIE Journal Paper | 10 May 2019 Open Access

Open Access

BabyLux device: a diffuse optical system integrating diffuse correlation spectroscopy and time-resolved near-infrared spectroscopy for the neuromonitoring of the premature newborn brain

Martina Giovannella, Davide Contini, Marco Pagliazzi, Antonio Pifferi, Lorenzo Spinelli, Rainer Erdmann, Roger Donat, Ignacio Rocchetti, Matthias Rehberger, Niels König, Robert Schmitt, Alessandro Torricelli, Turgut Durduran, Udo Weigel

NPh, Vol. 6, Issue 02, 025007, (May 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.2.025007

KEYWORDS: Optical properties, Near infrared spectroscopy, Sensors, Solids, Diffusion, Tissues, Spectroscopes, Liquids, Tissue optics, Neurophotonics

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SPIE Journal Paper | 7 February 2019 Open Access

Open Access

Time-domain near-infrared spectroscopy in acute ischemic stroke patients

Giacomo Giacalone, Marta Zanoletti, Rebecca Re, Bruno Germinario, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Luisa Roveri

NPh, Vol. 6, Issue 01, 015003, (February 2019) https://doi.org/10.1117/12.10.1117/1.NPh.6.1.015003

KEYWORDS: Control systems, Ischemic stroke, Near infrared spectroscopy, Brain, Tissues, Oxygen, Neuroimaging, Tissue optics, Neurophotonics, Photons

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Proceedings Article | 17 May 2018 Presentation + Paper

Presentation + Paper

Multidistance time domain diffuse optical spectroscopy in the assessment of abdominal fat heterogeneity

P. Lanka, A. Farina , S. Konugolu Venkata Sekar, C. Guadagno , L. Spinelli , P. Taroni, R. Cubeddu , E. Nisoli, A. Pifferi

Proceedings Volume 10685, 1068513 (2018) https://doi.org/10.1117/12.2307350

KEYWORDS: Absorption, Scattering, Tissues, Diffuse optical spectroscopy, Data modeling, Tissue optics, In vivo imaging, Optical properties, Abdomen, Medicine

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SPIE Journal Paper | 18 August 2017 Open Access

Open Access

In vivo measure of neonate brain optical properties and hemodynamic parameters by time-domain near-infrared spectroscopy

Lorenzo Spinelli, Lucia Zucchelli, Davide Contini, Matteo Caffini, Jacques Mehler, Ana Fló, Alissa Ferry, Luca Filippin, Francesco Macagno, Luigi Cattarossi, Alessandro Torricelli

NPh, Vol. 4, Issue 04, 041414, (August 2017) https://doi.org/10.1117/12.10.1117/1.NPh.4.4.041414

KEYWORDS: Brain, Optical properties, Near infrared spectroscopy, Hemodynamics, Absorption, Oxygen, In vivo imaging, Tissues, Head, Scattering

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Proceedings Article | 28 July 2017 Paper

Paper

In vivo depth heterogeneity of the abdomen assessed by broadband time-domain diffuse optical spectroscopy

A. Farina, S. Konugolu Venkata Sekar, C. Guadagno, L. Spinelli, P. Lanka, P. Taroni, R. Cubeddu, E. Nisoli, A. Pifferi

Proceedings Volume 10412, 104120M (2017) https://doi.org/10.1117/12.2286067

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Proceedings Article | 17 February 2017 Paper

Paper

Statistics of photon penetration depth in diffusive media

Lorenzo Spinelli, Andrea Farina, Tiziano Binzoni, Alessandro Torricelli, Antonio Pifferi, Fabrizio Martelli

Proceedings Volume 10059, 100590X (2017) https://doi.org/10.1117/12.2252367

KEYWORDS: Signal detection, Tissues, Photodetectors, Biomedical optics, Scattering media, Skin, Reflectivity, Neuroimaging, Brain, Scattering, Picosecond phenomena, Absorption, Diffusion, Radiative transfer

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SPIE Journal Paper | 17 June 2016 Open Access

Open Access

New frontiers in time-domain diffuse optics, a review

Antonio Pifferi, Davide Contini, Alberto Dalla Mora, Andrea Farina, Lorenzo Spinelli, Alessandro Torricelli

JBO, Vol. 21, Issue 09, 091310, (June 2016) https://doi.org/10.1117/12.10.1117/1.JBO.21.9.091310

KEYWORDS: Diffuse optical imaging, Sensors, Tissues, Near infrared spectroscopy, Optical fibers, Absorption, Electronics, Picosecond phenomena, Imaging systems, Continuous wave operation

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SPIE Journal Paper | 2 November 2015 Open Access

Open Access

Optimal estimation reconstruction of the optical properties of a two-layered tissue phantom from time-resolved single-distance measurements

Fabrizio Martelli, Samuele Del Bianco, Lorenzo Spinelli, Stefano Cavalieri, Paola Di Ninni, Tiziano Binzoni, Alexander Jelzow, Rainer Macdonald, Heidrun Wabnitz

JBO, Vol. 20, Issue 11, 115001, (November 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.11.115001

KEYWORDS: Optical properties, Tissues, Absorption, Tissue optics, Picosecond phenomena, Biological research, Data modeling, Reconstruction algorithms, Brain, Scattering

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SPIE Journal Paper | 28 July 2015 Open Access

Open Access

Mechanically switchable solid inhomogeneous phantom for performance tests in diffuse imaging and spectroscopy

Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu, Giovanna Quarto, Rebecca Re, Sanathana K. V. Sekar, Lorenzo Spinelli, Andrea Farina, Fabrizio Martelli, Heidrun Wabnitz

JBO, Vol. 20, Issue 12, 121304, (July 2015) https://doi.org/10.1117/12.10.1117/1.JBO.20.12.121304

KEYWORDS: Absorption, Solids, Picosecond phenomena, Scattering, Transmittance, Imaging spectroscopy, Sensors, Optical fibers, Optical properties, Reflectivity

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Proceedings Article | 16 July 2015 Paper

Paper

Fiber-based hybrid probe for non-invasive cerebral monitoring in neonatology

Matthias Rehberger, Martina Giovannella, Marco Pagliazzi, Udo Weigel, Turgut Durduran, Davide Contini, Lorenzo Spinelli, Antonio Pifferi, Alessandro Torricelli, Robert Schmitt

Proceedings Volume 9538, 95381J (2015) https://doi.org/10.1117/12.2197927

KEYWORDS: Oxygen, Blood circulation, Tissues, Time resolved spectroscopy, Head, Silicon, Optical fibers, Spectroscopy, In vivo imaging, Tissue optics

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Proceedings Article | 16 July 2015 Paper

Paper

Validation of time domain near infrared spectroscopy in muscle measurements: effect of a superficial layer

Rebecca Re, Davide Contini, Lucia Zucchelli, Lorenzo Spinelli, Alessandro Torricelli

Proceedings Volume 9538, 95380Y (2015) https://doi.org/10.1117/12.2183767

KEYWORDS: Hemodynamics, Near infrared spectroscopy, Tissue optics, In vivo imaging, Tissues, Computer simulations, Chromophores, Data modeling, Error analysis, Picosecond phenomena

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Proceedings Article | 16 July 2015 Paper

Paper

Design and construction of a solid switchable phantom for diffuse optical imaging

Antonio Pifferi, Fabrizio Martelli, Lorenzo Spinelli, Andrea Farina, Rebecca Re, Giovanna Quarto, Sanathana Konugolu Venkata Sekar, Alessandro Torricelli, Rinaldo Cubeddu, Mikhail Mazurenka, Rainer Macdonald, Heidrun Wabnitz

Proceedings Volume 9538, 95380Q (2015) https://doi.org/10.1117/12.2183657

KEYWORDS: Picosecond phenomena, Solids, Diffuse optical imaging, Absorption, Optical fibers, Reflectivity, Transmittance, Scattering, Optical properties, Brain

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Proceedings Article | 6 March 2015 Paper

Paper

Solid switchable phantom for diffuse optical imaging

Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu, Giovanna Quarto, Rebecca Re, Sanathana Konugolu Venkata Sekar, Lorenzo Spinelli, Andrea Farina, Fabrizio Martelli, Heidrun Wabnitz

Proceedings Volume 9325, 932505 (2015) https://doi.org/10.1117/12.2084789

KEYWORDS: Absorption, Solids, Transmittance, Scattering, Optical properties, Imaging systems, Picosecond phenomena, Diffuse optical imaging, Optical spheres, Electroluminescent displays

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SPIE Journal Paper | 14 August 2014 Open Access

Open Access

Performance assessment of time-domain optical brain imagers, part 1: basic instrumental performance protocol

Heidrun Wabnitz, Dieter Taubert, Mikhail Mazurenka, Oliver Steinkellner, Alexander Jelzow, Rainer Macdonald, Daniel Milej, Piotr Sawosz, Michał Kacprzak, Adam Liebert, Robert Cooper, Jeremy Hebden, Antonio Pifferi, Andrea Farina, Ilaria Bargigia, Davide Contini, Matteo Caffini, Lucia Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, Alessandro Torricelli

JBO, Vol. 19, Issue 08, 086010, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086010

KEYWORDS: Neuroimaging, Brain, Imaging systems, Sensors, Tissue optics, Biomedical optics, In vivo imaging, Transmittance, Absorption, Solids

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SPIE Journal Paper | 14 August 2014 Open Access

Open Access

Performance assessment of time-domain optical brain imagers, part 2: nEUROPt protocol

Heidrun Wabnitz, Alexander Jelzow, Mikhail Mazurenka, Oliver Steinkellner, Rainer Macdonald, Daniel Milej, Norbert Żołek, Michał Kacprzak, Piotr Sawosz, Roman Maniewski, Adam Liebert, Salavat Magazov, Jeremy Hebden, Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti, Alessandro Torricelli, Davide Contini, Rebecca Re, Lucia Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, Antonio Pifferi

JBO, Vol. 19, Issue 08, 086012, (August 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.8.086012

KEYWORDS: Absorption, Brain, Neuroimaging, Imaging systems, Optical properties, Sensors, Data analysis, Liquids, Biomedical optics, Spatial resolution

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SPIE Journal Paper | 14 July 2014 Open Access

Open Access

Phantoms for diffuse optical imaging based on totally absorbing objects, part 2: experimental implementation

Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Rinaldo Cubeddu, Heidrun Wabnitz, Mikhail Mazurenka, Rainer Macdonald, Angelo Sassaroli, Antonio Pifferi

JBO, Vol. 19, Issue 07, 076011, (July 2014) https://doi.org/10.1117/12.10.1117/1.JBO.19.7.076011

KEYWORDS: Absorption, Photons, Scattering, Optical properties, Liquids, Diffuse optical imaging, Solids, Reflectivity, Sensors, Monte Carlo methods

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Proceedings Article | 23 August 2013 Paper

Paper

Realistic inhomogeneous phantoms using an equivalent black volume

Fabrizio Martelli, Antonio Pifferi, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Mikhail Mazurenka, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, Paola Di Ninni, Giovanni Zaccanti

Proceedings Volume 8804, 88040F (2013) https://doi.org/10.1117/12.2036290

KEYWORDS: Monte Carlo methods, Absorption, Picosecond phenomena, Calibration, Optical spheres, Sensors, Diffuse optical imaging, Brain, Optical properties, Brain activation

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Proceedings Article | 24 June 2013 Paper

Paper

Multi-laboratory investigation of the optical properties of the human head

A. Farina, A. Pifferi, A. Torricelli, I. Bargigia, L. Spinelli, R. Cubeddu, F. Foschum, M. Jäger, E. Simon, O. Fugger, A. Kienle, F. Martelli, P. Di Ninni, G. Zaccanti, A. Jelzow, E. Kirilina, H. Wabnitz, J. Heiskala, M. Schweiger, S. Arridge

Proceedings Volume 8804, 880408 (2013) https://doi.org/10.1117/12.2032577

KEYWORDS: Head, Optical properties, Scattering, Absorption, Data modeling, Sensors, Skull, Signal detection, Data analysis

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Proceedings Article | 24 June 2013 Paper

Paper

Functional near-infrared spectroscopy at small source-detector distance by means of high dynamic-range fast-gated SPAD acquisitions: first in-vivo measurements

L. Di Sieno, D. Contini, A. Dalla Mora, A. Torricelli, L. Spinelli, R. Cubeddu, A. Tosi, G. Boso, A. Pifferi

Proceedings Volume 8804, 880402 (2013) https://doi.org/10.1117/12.2032492

KEYWORDS: Photons, Optical fibers, Near infrared spectroscopy, Sensors, Signal to noise ratio, In vivo imaging, Picosecond phenomena, Tissue optics, Avalanche photodiodes, Biomedical optics

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Proceedings Article | 24 June 2013 Paper

Paper

A method for discriminating systemic and cortical hemodynamic changes by time domain fNIRS

Lucia Zucchelli, Lorenzo Spinelli, Davide Contini, Rebecca Re, Alessandro Torricelli

Proceedings Volume 8804, 88040B (2013) https://doi.org/10.1117/12.2032503

KEYWORDS: Hemodynamics, Absorption, Head, Near infrared spectroscopy, Tissues, In vivo imaging, Brain, Photodetectors, Scattering, Multilayers

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Proceedings Article | 24 June 2013 Paper

Paper

Multichannel time domain fNIRS mapping of cortical activation and superficial systemic responses during neuromuscular electrical stimulation

R. Re, M. Muthalib, L. Zucchelli, S. Perrey, D. Contini, M. Caffini, L. Spinelli, G. Kerr, A. Torricelli

Proceedings Volume 8804, 880404 (2013) https://doi.org/10.1117/12.2032512

KEYWORDS: Cortical activation, Brain mapping, Photons, Hemodynamics, Scanning probe microscopy, Sensors, Head, Heart, Skin, Tissue optics

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SPIE Journal Paper | 18 June 2013 Open Access

Open Access

Phantoms for diffuse optical imaging based on totally absorbing objects, part 1: basic concepts

Fabrizio Martelli, Antonio Pifferi, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, Giovanni Zaccanti

JBO, Vol. 18, Issue 06, 066014, (June 2013) https://doi.org/10.1117/12.10.1117/1.JBO.18.6.066014

KEYWORDS: Absorption, Diffuse optical imaging, Monte Carlo methods, Sensors, Optical spheres, Scattering, Brain, Solids, Neuroimaging

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Proceedings Article | 14 June 2013 Paper

Paper

Optical identification of subjects at high risk for developing breast cancer

Paola Taroni, Giovanna Quarto, Antonio Pifferi, lorenzo Spinelli, Alessandro Torricelli, Francesca Ieva, Anna Maria Paganoni, Francesca Abbate, Nicola Balestreri, Simona Menna, Enrico Cassano, Rinaldo Cubeddu

Proceedings Volume 8799, 87990O (2013) https://doi.org/10.1117/12.2032456

KEYWORDS: Breast, Collagen, Scattering, Tissue optics, Breast cancer, Tissues, Mammography, Radio optics, Mie scattering, Data modeling

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Proceedings Article | 25 March 2013 Paper

Paper

Multi-channel time-resolved functional near infrared spectroscopy system

D. Contini, R. Re, M. Turola, L. Spinelli, G. Romano, R. Cubeddu, A. Torricelli

Proceedings Volume 8578, 857832 (2013) https://doi.org/10.1117/12.2004967

KEYWORDS: Brain, Absorption, Functional near infrared spectroscopy, Hemodynamics, Sensors, Tissues, Tissue optics, In vivo imaging, Signal to noise ratio, Control systems

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Proceedings Article | 25 March 2013 Paper

Paper

Investigation of verbal and visual working memory by multi-channel time-resolved functional near-infrared spectroscopy

D. Contini, M. Caffini, R. Re, L. Zucchelli, L. Spinelli, S. Basso Moro, S. Bisconti, M. Ferrari, V. Quaresima, S. Cutini, A. Torricelli

Proceedings Volume 8578, 85782Z (2013) https://doi.org/10.1117/12.2003777

KEYWORDS: Visualization, Near infrared spectroscopy, Prefrontal cortex, Heart, Information operations, Oximeters, Lithium, Hemodynamics, Neuroimaging, Barium

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Proceedings Article | 28 February 2013 Paper

Paper

Performance assessment of time-domain optical brain imagers: a multi-laboratory study

Heidrun Wabnitz, Alexander Jelzow, Mikhail Mazurenka, Oliver Steinkellner, Rainer Macdonald, Antonio Pifferi, Alessandro Torricelli, Davide Contini, Lucia Zucchelli, Lorenzo Spinelli, Rinaldo Cubeddu, Daniel Milej, Norbert Zolek, Michal Kacprzak, Piotr Sawosz, Adam Liebert, Salavat Magazov, Jeremy Hebden, Fabrizio Martelli, Paola Di Ninni, Giovanni Zaccanti

Proceedings Volume 8583, 85830L (2013) https://doi.org/10.1117/12.2002438

KEYWORDS: Absorption, Data analysis, Brain, Neuroimaging, Imaging systems, Spatial resolution, Liquids, Optical properties, Sensors, Brain imaging

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Proceedings Article | 28 February 2013 Paper

Paper

Realistic phantoms for diffuse optical imaging using totally absorbing objects

Antonio Pifferi, Fabrizio Martelli, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Heidrun Wabnitz, Rainer Macdonald, Angelo Sassaroli, Giovanni Zaccanti

Proceedings Volume 8583, 85830C (2013) https://doi.org/10.1117/12.2003665

KEYWORDS: Absorption, Monte Carlo methods, Diffuse optical imaging, Scattering, Optical spheres, Optical properties, Sensors, Diffusion, Photon transport

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SPIE Journal Paper | 4 May 2012 Open Access

Open Access

Load-dependent brain activation assessed by time-domain functional near-infrared spectroscopy during a working memory task with graded levels of difficulty

Erika Molteni, Giuseppe Baselli, Sergio Cerutti, Anna Maria Bianchi, Davide Contini, Matteo Caffini, Rinaldo Cubeddu, Alessandro Torricelli, Lorenzo Spinelli

JBO, Vol. 17, Issue 5, 056005, (May 2012) https://doi.org/10.1117/12.10.1117/1.JBO.17.5.056005

KEYWORDS: Brain activation, Data modeling, Cognitive modeling, Statistical analysis, Near infrared spectroscopy, Brain, Hemodynamics, Brain mapping, Functional magnetic resonance imaging, Control systems

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Proceedings Article | 15 June 2011 Paper

Paper

Non-contact time-domain scanning brain imager: results of proof of principle tests

M. Mazurenka, A. Jelzow, B. Ebert, H. Wabnitz, D. Contini, L. Spinelli, A. Pifferi, A. Dalla Mora, A. Tosi, R. Macdonald

Proceedings Volume 8088, 80880A (2011) https://doi.org/10.1117/12.889708

KEYWORDS: Photons, Picosecond phenomena, Sensors, Imaging systems, Cameras, Neuroimaging, Brain, Liquids, Near infrared spectroscopy, Confocal microscopy

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Proceedings Article | 15 June 2011 Paper

Paper

Anatomical brain atlas for NIRS measurements of brain activation

Matteo Caffini, Lucia Zucchelli, Davide Contini, Rinaldo Cubeddu, Lorenzo Spinelli, David Boas, Alessandro Torricelli

Proceedings Volume 8088, 808809 (2011) https://doi.org/10.1117/12.889679

KEYWORDS: Visualization, Sensors, Near infrared spectroscopy, Brain, Head, Brain activation, Absorption, Monte Carlo methods, Neuroimaging, Photon transport

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Proceedings Article | 15 June 2011 Paper

Paper

Breast density assessment by means of time domain optical mammography at 635-1060 nm

Paola Taroni, Antonio Pifferi, Giovanna Quarto, Lorenzo Spinelli, Alessandro Torricelli, Rinaldo Cubeddu, Francesca Abbate, Anna Villa, Nicola Balestreri, Simona Menna, Enrico Cassano

Proceedings Volume 8088, 80881E (2011) https://doi.org/10.1117/12.889373

KEYWORDS: Breast, Collagen, Tissue optics, Tissues, Scattering, Mammography, Absorption, Breast cancer, Radio optics, Diagnostics

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Proceedings Article | 15 June 2011 Paper

Paper

Assessment of cortical response during motor task in adults by a multimodality approach based on fNIRS-EEG, fMRI-EEG, and TMS

Alessandro Torricelli, Davide Contini, Matteo Caffini, Lucia Zucchelli, Rinaldo Cubeddu, Lorenzo Spinelli, Erika Molteni, Anna Maria Bianchi, Giuseppe Baselli, Sergio Cerutti, Elisa Visani, Isabella Gilioli, Davide Rossi Sebastiano, Elena Schiaffi, Ferruccio Panzica, Silvana Franceschetti

Proceedings Volume 8088, 808802 (2011) https://doi.org/10.1117/12.889809

KEYWORDS: Functional magnetic resonance imaging, Electroencephalography, Brain mapping, Fiber optics, Functional imaging, Near infrared spectroscopy, Neuroimaging, Light sources, Magnetic resonance imaging, Electrodes

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Proceedings Article | 1 March 2011 Paper

Paper

Wavelength and code-division multiplexing in diffuse optical imaging

Luca Ascari, Gianluca Berrettini, Sandro Iannaccone, Matteo Giacalone, Davide Contini, Lorenzo Spinelli, Maria Giovanna Trivella, Antonio L'Abbate, Luca Potí

Proceedings Volume 7896, 789620 (2011) https://doi.org/10.1117/12.875132

KEYWORDS: Signal to noise ratio, Code division multiplexing, Diffuse optical imaging, Gold, Modulation, Tissues, Continuous wave operation, Modulators, Receivers, Near infrared

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Proceedings Article | 18 February 2011 Paper

Paper

In vivo swine myocardial tissue characterization and monitoring during open chest surgery by time-resolved diffuse near-infrared spectroscopy

Lorenzo Spinelli, Davide Contini, Andrea Farina, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu, Luca Ascari, Luca Potì, Maria Giovanna Trivella, Antonio L'Abbate, Stefano Puzzuoli

Proceedings Volume 7883, 78833D (2011) https://doi.org/10.1117/12.874697

KEYWORDS: Heart, Tissue optics, Near infrared spectroscopy, Absorption, Chest, Scattering, Surgery, Tissues, In vivo imaging, Light scattering

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Proceedings Article | 17 February 2011 Paper

Paper

Assessment of basic instrumental performance of time-domain optical brain imagers

Heidrun Wabnitz, Antonio Pifferi, Alessandro Torricelli, Dieter Taubert, Mikhail Mazurenka, Oliver Steinkellner, Alexander Jelzow, Andrea Farina, Ilaria Bargigia, Davide Contini, Matteo Caffini, Lucia Zucchelli, Lorenzo Spinelli, Piotr Sawosz, Adam Liebert, Rainer Macdonald, Rinaldo Cubeddu

Proceedings Volume 7896, 789602 (2011) https://doi.org/10.1117/12.874654

KEYWORDS: Neuroimaging, Brain, Imaging systems, Sensors, Tissue optics, Transmittance, Electronics, Photomultipliers, Brain imaging, Picosecond phenomena

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SPIE Journal Paper | 1 November 2010 Open Access

Open Access

Noninvasive assessment of breast cancer risk using time-resolved diffuse optical spectroscopy

Paola Taroni, Antonio Pifferi, Giovanna Quarto, Lorenzo Spinelli, Alessandro Torricelli, Francesca Abbate, Anna Villa, Nicola Balestreri, Simona Menna, Enrico Cassano, Rinaldo Cubeddu

JBO, Vol. 15, Issue 06, 060501, (November 2010) https://doi.org/10.1117/12.10.1117/1.3506043

KEYWORDS: Breast, Collagen, Tissue optics, Breast cancer, Tissues, Scattering, Transmittance, Diffuse optical spectroscopy, Radio optics, Mammography

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SPIE Journal Paper | 1 September 2010 Open Access

Open Access

Noninvasive observation of skeletal muscle contraction using near-infrared time-resolved reflectance and diffusing-wave spectroscopy

Markus Belau, Markus Ninck, Gernot Hering, Lorenzo Spinelli, Davide Contini, Alessandro Torricelli, Thomas Gisler

JBO, Vol. 15, Issue 05, 057007, (September 2010) https://doi.org/10.1117/12.10.1117/1.3503398

KEYWORDS: Optical fibers, Reflectance spectroscopy, Diffusion, Tissue optics, Spectroscopy, Tissues, Optical testing, Optical properties, Scattering, Reflectivity

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Proceedings Article | 29 April 2010 Paper

Paper

Functional diffuse reflectance spectroscopy at small source-detector distances based on fast-gated single-photon avalanche diodes

Davide Contini, Antonio Pifferi, Lorenzo Spinelli, Alessandro Torricelli, Rinaldo Cubeddu, Fabrizio Martelli, Giovanni Zaccanti, Alberto Dalla Mora, Alberto Tosi, Franco Zappa, Sergio Cova

Proceedings Volume 7681, 768102 (2010) https://doi.org/10.1117/12.852557

KEYWORDS: Diffuse reflectance spectroscopy, Picosecond phenomena, Avalanche photodiodes, Biomedical optics, Photodetectors, Brain, Spatial resolution, Reflectivity, Absorption, Sensors

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Proceedings Article | 24 February 2010 Paper

Paper

Fast-gated single-photon detectors boost dynamic range in NIR spectroscopy

A. Tosi, A. Dalla Mora, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, R. Cubeddu

Proceedings Volume 7556, 75560G (2010) https://doi.org/10.1117/12.840910

KEYWORDS: Photodetectors, Picosecond phenomena, Sensors, Signal detection, Near infrared spectroscopy, Near infrared, Silicon, Single photon detectors, Time metrology, Biomedical optics

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Proceedings Article | 10 September 2009 Paper

Paper

In-situ analysis of fruit anthocyanins by means of total internal reflectance, continuous wave and time-resolved spectroscopy

Manuela Zude, Lorenzo Spinelli, Carsten Dosche, Alessandro Torricelli

Proceedings Volume 7432, 74320H (2009) https://doi.org/10.1117/12.823157

KEYWORDS: Refractive index, Calibration, Chemical analysis, Scattering, Luminescence, Spectroscopy, Time resolved spectroscopy, Reflectivity, Agriculture

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Proceedings Article | 10 July 2009 Paper

Paper

Hybrid heuristic time dependent solution of the radiative transfer equation for the slab

Fabrizio Martelli, Samuele Del Bianco, Antonio Pifferi, Lorenzo Spinelli, Alessandro Torricelli, Giovanni Zaccanti

Proceedings Volume 7369, 73691B (2009) https://doi.org/10.1117/12.831689

KEYWORDS: Radiative transfer, Monte Carlo methods, Photon transport, Diffusion, Transmittance, Reflectivity, Tissues, Scattering, Receivers, Analytical research

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Proceedings Article | 10 July 2009 Paper

Paper

Tomography of brain activation using a time-gated camera

Antonio Pifferi, Qing Zhao, Lorenzo Spinelli, Andrea Bassi, Gianluca Valentini, Davide Contini, Alessandro Torricelli, Rinaldo Cubeddu

Proceedings Volume 7369, 73690R (2009) https://doi.org/10.1117/12.831683

KEYWORDS: Cameras, Tomography, 3D modeling, In vivo imaging, Brain activation, Optical fibers, Functional imaging, Optical tomography, Imaging systems, 3D metrology

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Proceedings Article | 10 July 2009 Paper

Paper

Nonlinear fitting procedure for accurate time-resolved measurements in diffusive media

Lorenzo Spinelli, Fabrizio Martelli, Alessandro Torricelli, Antonio Pifferi, Giovanni Zaccanti

Proceedings Volume 7369, 73691C (2009) https://doi.org/10.1117/12.831651

KEYWORDS: Absorption, Scattering, Monte Carlo methods, Optical properties, Data modeling, Nonlinear optics, Calibration, Picosecond phenomena, Computer simulations, Device simulation

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Proceedings Article | 10 July 2009 Paper

Paper

Effects of a finite spectral bandwidth light source in time-resolved diffuse spectroscopy

Andrea Farina, Andrea Bassi, Paola Taroni, Daniela Comelli, Lorenzo Spinelli, Rinaldo Cubeddu, Antonio Pifferi

Proceedings Volume 7369, 73690V (2009) https://doi.org/10.1117/12.831695

KEYWORDS: Absorption, Light sources, Chromophores, Time resolved spectroscopy, Spectroscopy, Reflectivity, Tissues, Signal detection, Scattering, Biological research

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Proceedings Article | 10 July 2009 Paper

Paper

Time-resolved optical stratigraphy in turbid media

Lorenzo Spinelli, Antonio Pifferi, Davide Contini, Rinaldo Cubeddu, Alessandro Torricelli

Proceedings Volume 7371, 73710A (2009) https://doi.org/10.1117/12.831738

KEYWORDS: Absorption, In vivo imaging, Tomography, Reflectivity, Picosecond phenomena, Hemodynamics, Monte Carlo methods, Scattering, Lithium, Numerical simulations

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Proceedings Article | 10 July 2009 Paper

Paper

A multichannel time-domain brain oximeter for clinical studies

Davide Contini, Lorenzo Spinelli, Matteo Caffini, Rinaldo Cubeddu, Alessandro Torricelli

Proceedings Volume 7369, 73691D (2009) https://doi.org/10.1117/12.831663

KEYWORDS: Brain, Signal attenuation, Signal detection, Control systems, Attenuators, Oximeters, Fiber optics, Biomedical optics, Safety, Lasers

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Proceedings Article | 9 July 2009 Paper

Paper

Intra- and extra-cortical activation during a working memory task assessed by time-resolved near-infrared spectroscopy (fNIRS)

Erika Molteni, Anna Bianchi, Giuseppe Baselli, Matteo Caffini, Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Sergio Cerutti, Rinaldo Cubeddu

Proceedings Volume 7369, 736903 (2009) https://doi.org/10.1117/12.831645

KEYWORDS: Near infrared spectroscopy, Tissues, Photons, Brain, Fiber optics, Prefrontal cortex, Absorption, Cortical activation, Blood, Hemodynamics

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Proceedings Article | 8 July 2009 Paper

Paper

A compact time-resolved system for NIR spectroscopy

Rebecca Re, Davide Contini, Matteo Caffini, Lorenzo Spinelli, Rinaldo Cubeddu, Alessandro Torricelli

Proceedings Volume 7368, 736815 (2009) https://doi.org/10.1117/12.831610

KEYWORDS: Near infrared, Absorption, Near infrared spectroscopy, Spectroscopy, Scattering, Time resolved spectroscopy, Tissue optics, Hemodynamics, Tissues, Neodymium

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Proceedings Article | 8 July 2009 Paper

Paper

Time-resolved diffuse optical spectroscopy: a differential absorption approach

Paola Taroni, Andrea Bassi, Lorenzo Spinelli, Rinaldo Cubeddu, Antonio Pifferi

Proceedings Volume 7368, 73681N (2009) https://doi.org/10.1117/12.831557

KEYWORDS: Absorption, Scattering, Error analysis, Diffuse optical spectroscopy, Biological research, Reflectivity, Biomedical optics, Tissues, Picosecond phenomena, Light scattering

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SPIE Journal Paper | 1 July 2009 Open Access

Open Access

Monitoring muscle metabolic indexes by time-domain near-infrared spectroscopy during knee flex-extension induced by functional electrical stimulation

Simona Ferrante, Davide Contini, Lorenzo Spinelli, Alessandra Pedrocchi, Alessandro Torricelli, Franco Molteni, Giancarlo Ferrigno, Rinaldo Cubeddu

JBO, Vol. 14, Issue 04, 044011, (July 2009) https://doi.org/10.1117/12.10.1117/1.3183802

KEYWORDS: Near infrared spectroscopy, Mode conditioning cables, Hemodynamics, Blood circulation, Oxygen, Robotics, Optical fibers, Pathology, Tissues, Motion analysis

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Proceedings Article | 24 February 2009 Paper

Paper

Functional brain tomography using a time-gated ICCD camera

Antonio Pifferi, Qing Zhao, Lorenzo Spinelli, Andrea Bassi, Gianluca Valentini, Davide Contini, Rinaldo Cubeddu, Alessandro Torricelli

Proceedings Volume 7174, 71741L (2009) https://doi.org/10.1117/12.809690

KEYWORDS: Cameras, Tomography, Photons, Brain, In vivo imaging, Absorption, Imaging systems, Picosecond phenomena, CCD cameras, 3D modeling

Read Abstract +

Proceedings Article | 23 February 2009 Paper

Paper

Fast-gated single-photon avalanche diode for extremely wide dynamic-range applications

A. Tosi, A. Dalla Mora, F. Zappa, S. Cova, D. Contini, A. Pifferi, L. Spinelli, A. Torricelli, R. Cubeddu

Proceedings Volume 7170, 71700K (2009) https://doi.org/10.1117/12.809205

KEYWORDS: Picosecond phenomena, Sensors, Imaging spectroscopy, Pulsed laser operation, Tissue optics, Pulse generators, Tissues, Avalanche photodiodes, Signal detection, Silicon

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Proceedings Article | 23 February 2009 Paper

Paper

Measurement of the local muscular metabolism by time-domain near infrared spectroscopy during knee flex-extension induced by functional electrical stimulation

D. Contini, L. Spinelli, A. Torricelli, S. Ferrante, A. Pedrocchi, F. Molteni, G. Ferrigno, R. Cubeddu

Proceedings Volume 7169, 71690P (2009) https://doi.org/10.1117/12.809028

KEYWORDS: Near infrared spectroscopy, Hemodynamics, Mode conditioning cables, Blood circulation, Tissues, Blood, Optical fibers, Pathology, Picosecond phenomena, Light

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Proceedings Article | 23 February 2009 Paper

Paper

Brain functional imaging at small source-detector distances based on fast-gated single-photon avalanche diodes

Lorenzo Spinelli, Davide Contini, Rinaldo Cubeddu, Antonio Pifferi, Alessandro Torricelli, Fabrizio Martelli, Giovanni Zaccanti, Alberto Tosi, Alberto Dalla Mora, Franco Zappa, Sergio Cova

Proceedings Volume 7161, 71613B (2009) https://doi.org/10.1117/12.808245

KEYWORDS: Picosecond phenomena, Photons, Numerical simulations, Brain, Avalanche photodiodes, Electronics, Optical properties, Tissue optics, Silicon, Monte Carlo methods

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Proceedings Article | 23 February 2009 Paper

Paper

Frontal brain activation during a working memory task: a time-domain fNIRS study

E. Molteni, G. Baselli, A. M. Bianchi, M. Caffini, D. Contini, L. Spinelli, A. Torricelli, S. Cerutti, R. Cubeddu

Proceedings Volume 7161, 71613N (2009) https://doi.org/10.1117/12.808972

KEYWORDS: Rhodium, Near infrared spectroscopy, Fourier transforms, Brain, Brain activation, Blood, Hemodynamics, Photons, Statistical analysis, Prefrontal cortex

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Proceedings Article | 12 February 2009 Paper

Paper

Accuracy of the nonlinear fitting procedure for time-resolved measurements on diffusive phantoms at NIR wavelengths

Lorenzo Spinelli, Fabrizio Martelli, Andrea Farina, Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu, Giovanni Zaccanti

Proceedings Volume 7174, 717424 (2009) https://doi.org/10.1117/12.808997

KEYWORDS: Scattering, Absorption, Monte Carlo methods, Optical properties, Data modeling, Picosecond phenomena, Signal to noise ratio, Near infrared, Photon counting, Geometrical optics

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Proceedings Article | 22 October 2007 Paper

Paper

Time-resolved reflectance spectroscopy for nondestructive assessment of fruit and vegetable quality

Alessandro Torricelli, Lorenzo Spinelli, Maristella Vanoli, Anna Rizzolo, Paola Eccher Zerbini

Proceedings Volume 6761, 67610Y (2007) https://doi.org/10.1117/12.751793

KEYWORDS: Scattering, Absorption, Light scattering, Reflectance spectroscopy, Nondestructive evaluation, Mie scattering, Near infrared, Photomultipliers, Tissues, Biological research

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Proceedings Article | 15 October 2007 Paper

Paper

Time-gated single-photon avalanche diode for time-resolved diffuse reflectance at small source-detector separation

Alessandro Torricelli, Antonio Pifferi, Loreno Spinelli, Davide Contini, Rinaldo Cubeddu, Alberto Tosi, Alberto Dalla Mora, Franco Zappa, Sergio Cova

Proceedings Volume 6771, 67710J (2007) https://doi.org/10.1117/12.731778

KEYWORDS: Reflectivity, Avalanche photodiodes, Photodetectors, Diffuse reflectance spectroscopy, Picosecond phenomena, Absorption, Solids, Spatial resolution, Tissue optics, Scattering

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Proceedings Article | 7 August 2007 Paper

Paper

Simultaneous acquisition of time-domain fNIRS and fMRI during motor activity

Alessandro Torricelli, Davide Contini, Antonio Pifferi, Lorenzo Spinelli, Rinaldo Cubeddu, Luca Nocetti, Angela-Agnes Manginelli, Patrizia Baraldi

Proceedings Volume 6631, 66310A (2007) https://doi.org/10.1117/12.727699

KEYWORDS: Functional magnetic resonance imaging, Absorption, Brain, Hemodynamics, Einsteinium, Magnetic resonance imaging, Brain mapping, Head, Temporal resolution, Biomedical optics

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Proceedings Article | 20 July 2007 Paper

Paper

Continuous performance test assessed with time-domain functional near infrared spectroscopy

Alessandro Torricelli, Davide Contini, Lorenzo Spinelli, Matteo Caffini, Michele Butti, Giuseppe Baselli, Anna Bianchi, Alessandra Bardoni, Sergio Cerutti, Rinaldo Cubeddu

Proceedings Volume 6629, 66291M (2007) https://doi.org/10.1117/12.727952

KEYWORDS: Prefrontal cortex, Hemodynamics, Functional near infrared spectroscopy, Near infrared spectroscopy, Sensors, Absorption, Switches, Signal detection, Biomedical optics, Brain

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Proceedings Article | 20 July 2007 Paper

Paper

White-light time-resolved reflectance spectroscopy for monitoring constituents concentrations in layered diffusive media

A. Giusto, C. D'Andrea, L. Spinelli, D. Contini, A. Torricelli, F. Martelli, G. Zaccanti, R. Cubeddu

Proceedings Volume 6628, 66281G (2007) https://doi.org/10.1117/12.728102

KEYWORDS: Tissues, Absorption, In vivo imaging, Brain, Spectroscopy, Oximetry, Photonic crystal fibers, Time resolved spectroscopy, Reflectance spectroscopy, Reflectivity

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Proceedings Article | 20 July 2007 Paper

Paper

Monitoring muscle metabolic indexes by time-domain near infrared spectroscopy during knee flex-extension induced by functional electrical stimulation

Alessandro Torricelli, Davide Contini, Lorenzo Spinelli, Rinaldo Cubeddu, Franco Molteni, Simona Ferrante, Alessandra Pedrocchi, Giancarlo Ferrigno

Proceedings Volume 6629, 66291L (2007) https://doi.org/10.1117/12.727948

KEYWORDS: Near infrared spectroscopy, Optical fibers, Hemodynamics, Electrodes, Absorption, Tissue optics, Switches, Biomedical optics, Tissues, Light

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Proceedings Article | 17 July 2007 Paper

Paper

Time-resolved diffuse reflectance at small source-detector separation using a time-gated single-photon avalanche diode

Antonio Pifferi, Alessandro Torricelli, Lorenzo Spinelli, Davide Contini, Rinaldo Cubeddu, Fabrizio Martelli, Giovanni Zaccanti, Alberto Tosi, Alberto Dalla Mora, Franco Zappa, Sergio Cova

Proceedings Volume 6631, 66310B (2007) https://doi.org/10.1117/12.727947

KEYWORDS: Reflectivity, Avalanche photodiodes, Picosecond phenomena, Photodetectors, Diffuse reflectance spectroscopy, Tissue optics, Absorption, Pulsed laser operation, Solids, Spatial resolution

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Proceedings Article | 12 July 2007 Paper

Paper

CW and time domain procedures for accurate calibration of optical properties of liquid diffusive media at NIR wavelengths

F. Martelli, L. Spinelli, A. Farina, A. Pifferi, A. Torricelli, R. Cubeddu, G. Zaccanti

Proceedings Volume 6629, 66290H (2007) https://doi.org/10.1117/12.728178

KEYWORDS: Absorption, Scattering, Calibration, Optical properties, Error analysis, Liquids, Near infrared, Receivers, Light scattering

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Proceedings Article | 12 July 2007 Paper

Paper

Assessment of collagen absorption and related potential diagnostic applications

Paola Taroni, Daniela Comelli, Arianna Giusto, Antonio Pifferi, Natasha Shah, Lorenzo Spinelli, Alessandro Torricelli, Rinaldo Cubeddu

Proceedings Volume 6629, 66290D (2007) https://doi.org/10.1117/12.727817

KEYWORDS: Collagen, Breast, Absorption, Tissue optics, Tissues, Diagnostics, Scattering, Mammography, Breast cancer, Blood

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Proceedings Article | 12 July 2007 Paper

Paper

Novel method for depth-resolved brain functional imaging by time-domain NIRS

Davide Contini, Lorenzo Spinelli, Alessandro Torricelli, Antonio Pifferi, Rinaldo Cubeddu

Proceedings Volume 6629, 662908 (2007) https://doi.org/10.1117/12.728104

KEYWORDS: Brain, Monte Carlo methods, Absorption, In vivo imaging, Neuroimaging, Functional imaging, Near infrared spectroscopy, Hemodynamics, Photon transport, Tissue optics

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Proceedings Article | 11 July 2007 Paper

Paper

Time-resolved scanning system for double reflectance and transmittance fluorescence imaging of small animals

Marco Brambilla, Lorenzo Spinelli, Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu

Proceedings Volume 6626, 66260L (2007) https://doi.org/10.1117/12.727883

KEYWORDS: Luminescence, Transmittance, Imaging systems, Reflectivity, Molecular imaging, Optical properties, Preclinical imaging, Optical filters, Tissues, Tissue optics

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SPIE Journal Paper | 1 September 2006 Open Access

Open Access

Feasibility of white-light time-resolved optical mammography

Andrea Bassi, Lorenzo Spinelli, Cosimo D'Andrea, Arianna Giusto, Johannes Swartling, Antonio Pifferi, Alessandro Torricelli, Rinaldo Cubeddu

JBO, Vol. 11, Issue 05, 054035, (September 2006) https://doi.org/10.1117/12.10.1117/1.2355663

KEYWORDS: Breast, Mammography, Tissue optics, Absorption, Tissues, Scattering, Biomedical optics, Photonic crystal fibers, Time metrology, Photon counting

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Proceedings Article | 8 October 2005 Paper

Paper

Experimental assessment of analytical models for estimating tumor optical properties in laser pulse mammography

D. Grosenick, B. Wassermann, R. Macdonald, H. Rinneberg, A. Torricelli, L. Spinelli, R. Cubeddu

Proceedings Volume 5859, 58590M (2005) https://doi.org/10.1117/12.632842

KEYWORDS: Optical spheres, Absorption, Optical properties, Scattering, Diffraction, Data modeling, Tumors, Spherical lenses, Finite element methods, Breast

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SPIE Journal Paper | 1 January 2005 Open Access

Open Access

Bilateral prefrontal cortex oxygenation responses to a verbal fluency task: a multichannel time-resolved near-infrared topography study

Valentina Quaresima, Marco Ferrari, Alessandro Torricelli, Lorenzo Spinelli, Antonio Pifferi, Rinaldo Cubeddu

JBO, Vol. 10, Issue 01, 011012, (January 2005) https://doi.org/10.1117/12.10.1117/1.1851512

KEYWORDS: Continuous wave operation, Prefrontal cortex, Near infrared spectroscopy, Functional magnetic resonance imaging, Brain, Oxygen, Positron emission tomography, Signal detection, Tissues, Cortical activation

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SPIE Journal Paper | 1 November 2004 Open Access

Open Access

Bulk optical properties and tissue components in the female breast from multiwavelength time-resolved optical mammography

Lorenzo Spinelli, Alessandro Torricelli, Antonio Pifferi, Paola Taroni, Gian Maria Danesini, Rinaldo Cubeddu

JBO, Vol. 9, Issue 06, (November 2004) https://doi.org/10.1117/12.10.1117/1.1803546

KEYWORDS: Breast, Tissue optics, Absorption, Scattering, Tissues, Optical properties, Blood oxygen saturation, Brain-machine interfaces, Mammography, Transmittance

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SPIE Journal Paper | 1 May 2004 Open Access

Open Access

Clinical trial of time-resolved scanning optical mammography at 4 wavelengths between 683 and 975 nm

Paola Taroni, Gian Maria Danesini, Alessandro Torricelli, Antonio Pifferi, Lorenzo Spinelli, Rinaldo Cubeddu

JBO, Vol. 9, Issue 03, (May 2004) https://doi.org/10.1117/12.10.1117/1.1695561

KEYWORDS: Breast, Scattering, Absorption, Tissue optics, Mammography, Tissues, Visibility, Cancer, Tumors, X-rays

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Proceedings Article | 15 October 2003 Paper

Paper

Clinical trial on time-resolved optical mammography at four wavelengths (680–975 nm)

Paola Taroni, Antonio Pifferi, Lorenzo Spinelli, Alessandro Torricelli, Gian Maria Danesini, Rinaldo Cubeddu

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.500596

KEYWORDS: Breast, Mammography, Scattering, Clinical trials, Absorption, Tumors, X-rays, Tissues, X-ray imaging, X-ray optics

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Proceedings Article | 15 October 2003 Paper

Paper

Breast lesion characterization by a novel nonlinear perturbation approach

Rinaldo Cubeddu, Antonio Pifferi, Lorenzo Spinelli, Paola Taroni, Alessandro Torricelli

Proceedings Volume 5138, (2003) https://doi.org/10.1117/12.502088

KEYWORDS: Absorption, Tissue optics, Breast, Scattering, Transmittance, Optical properties, Tissues, Mammography, In vivo imaging, Data modeling

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Proceedings Article | 29 July 2003 Paper

Paper

Four-wavelength time-resolved optical mammograph

Rinaldo Cubeddu, Gian Maria Danesini, Fabrizio Messina, Antonio Pifferi, Lorenzo Spinelli, Paola Taroni, Alessandro Torricelli

Proceedings Volume 4955, (2003) https://doi.org/10.1117/12.478134

KEYWORDS: Breast, Absorption, Tissues, Tissue optics, Mammography, X-rays, X-ray optics, Tumors, Scattering, Blood

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Proceedings Article | 1 April 2002 Paper

Paper

Theoretical aspects and potential applications of cavity solitons in semiconductor microresonators

Tommaso Maggipinto, Massimo Brambilla, I. Perrini, Lorenzo Spinelli, Giovanna Tissoni

Proceedings Volume 4750, (2002) https://doi.org/10.1117/12.464476

KEYWORDS: Solitons, Semiconductors, Thermal effects, Thermal modeling, Diffusion, Microresonators, Modulation, Diffraction, Gallium arsenide, Bistability

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Proceedings Article | 9 July 2001 Paper

Paper

Thermal and electronic nonlinearities in semiconductor cavities

Giovanna Tissoni, Lorenzo Spinelli, Luigi Lugiato, Massimo Brambilla

Proceedings Volume 4283, (2001) https://doi.org/10.1117/12.432608

KEYWORDS: Semiconductors, Diffusion, Thermal effects, Diffraction, Solitons, Switching, Bistability, Optical microcavities, Thermal modeling, Refractive index

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Proceedings Article | 9 July 2001 Paper

Paper

Controlling cavity solitons in semiconductor microcavities for optical information treatment

Massimo Brambilla, Tommaso Maggipinto, I. Perrini, Lorenzo Spinelli, Giovanna Tissoni

Proceedings Volume 4283, (2001) https://doi.org/10.1117/12.432606

KEYWORDS: Solitons, Semiconductors, Optical microcavities, Inspection, Microresonators, Bistability, Optical semiconductors, Modulation, Partial differential equations, Data processing

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Proceedings Article | 14 July 2000 Paper

Paper

Cavity solitons in semiconductor devices

Massimo Brambilla, Luigi Lugiato, Tommaso Maggipinto, Lorenzo Spinelli, Giovanna Tissoni

Proceedings Volume 3944, (2000) https://doi.org/10.1117/12.391425

KEYWORDS: Semiconductors, Solitons, Absorption, Modulation, Refractive index, Spatial solitons, Quantum wells, Systems modeling, Nonlinear optics, Optical resonators

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Showing 5 of 109 publications

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